Nicolas Sailliet

Identification of Neuropilin 2 on a B Cell Subset with a Regulatory Phenotype

Nicolas Sailliet, Mai Komatsu, David M. Briscoe, Johannes Wedel

Purpose: In previous studies, we identified a select human B cell subset with Neuropilin 2 (NRP2) expression in a humanized SCID-beige mouse model of xenoactivation. We also found that NRP2 activity is required for long-term cardiac graft survival in a murine transplantation …

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Immunomodulation by allograft endothelial cells

Sayantan Bose, Vicki Do, Chiara Testini, Suchita Suryakant Jadhav et autres

It is increasingly appreciated that the expression of immunoregulatory molecules within tumors have potential to shape a microenvironment that promotes local immunoevasion and immunoregulation. However, little is known about tissue-intrinsic immunomodulatory mechanisms following transplantation. We propose that differences in the phenotype of …

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Rise of a CD27 − IgD − CD11c + B cells population in kidney recipients achieving long‐term graft stability under immunosuppression

François Brinas, Nicolas Sailliet, Gaëlle Tilly, Laurence Bouchet‐Delbos et autres

Abstract The use of immunosuppressive treatment is required to prevent rejection events, even a long time after kidney transplantation despite rare recipients achieving long‐term graft stability without the need for immunosuppressive treatment, called operationally tolerant patients (TOLs). We comprehensively investigate the immune …

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Author response for "Rise of a CD27− IgD− CD11c+ B cells population in kidney recipients achieving long‐term graft stability under immunosuppression"

François Brinas, Nicolas Sailliet, Gaëlle Tilly, Laurence Bouchet‐Delbos et autres

Author response for "Rise of a CD27− IgD− CD11c+ B cells population in kidney recipients achieving long‐term graft stability under immunosuppression"

François Brinas, Nicolas Sailliet, Gaëlle Tilly, Laurence Bouchet‐Delbos et autres

Regulatory B Cells Expressing Granzyme B from Tolerant Renal Transplant Patients: Highly Differentiated B Cells with a Unique Pathway with a Specific Regulatory Profile and Strong Interactions with Immune System Cells

Nicolas Sailliet, Amandine Dupuy, François Brinas, Karine Renaudin et autres

The aim of our study was to determine whether granzyme B-expressing regulatory B cells (GZMB+ B cells) are enriched in the blood of transplant patients with renal graft tolerance. To achieve this goal, we analysed two single-cell RNA sequencing (scRNAseq) datasets: (1) …

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Author response for "Rise of a CD27− IgD− CD11c+ B cells population in kidney recipients achieving long‐term graft stability under immunosuppression"

François Brinas, Nicolas Sailliet, Gaëlle Tilly, Laurence Bouchet‐Delbos et autres

Human granzyme B regulatory B cells prevent effector CD4+CD25- T cell proliferation through a mechanism dependent from lymphotoxin alpha

Nicolas Sailliet, Hoa‐Le Mai, Amandine Dupuy, Gaëlle Tilly et autres

Introduction: Human Granzyme B (GZMB) regulatory B cells (Bregs) have suppressive properties on CD4+ effector T cells by a mechanism partially dependent on GZMB. Moreover, these cells may be easily induced in vitro making them interesting for cell therapy. Methods: We characterized …

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The Role of BOB1 in Chronic Lung Allograft Dysfunction

Nataliya Yeremenko, Aurore Foureau, Nicolas Sailliet, Éric Durand et autres

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Caractérisation transcriptionnelle phénotypique et fonctionnelle des lymphocytes B GZMB+ dans le sang des volontaires sains : développement de tests immunologiques pour mesurer l’impact des voies JAK dans la dermatite atopique

Nicolas Sailliet

Les lymphocytes B régulateurs sont une population hautement hétérogène qui a montré son efficacité à supprimer les mécanismes effecteurs du système immunitaire. Dans la première partie de cette thèse nous allons étudier la population de lymphocytes B régulateurs mis en évidence chez …

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Caractérisation transcriptionnelle phénotypique et fonctionnelle des lymphocytes B GZMB+ dans le sang des volontaires sains : développement de tests immunologiques pour mesurer l’impact des voies JAK dans la dermatite atopique

Nicolas Sailliet

Les lymphocytes B régulateurs sont une population hautement hétérogène qui a montré son efficacité à supprimer les mécanismes effecteurs du système immunitaire. Dans la première partie de cette thèse nous allons étudier la population de lymphocytes B régulateurs mis en évidence chez …

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Extracellular Vesicles in Transplantation

Nicolas Sailliet, Matti Ullah, Amandine Dupuy, Amanda Silva et autres

Extracellular vesicles (EVs) have been extensively studied in the last two decades. It is now well documented that they can actively participate in the activation or regulation of immune system functions through different mechanisms, the most studied of which include protein-protein interactions …

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