U. E. Uzuegbu

Computational Investigation of Lupeol Acetylsalicylate Derivatives as Potential Antimalarial Agents Targeting Plasmodium falciparum Hsp 90 and SERA 6 Proteins

Evelyn Tarela Ojugbeli, D. A. Onobrudu, Prosper Ejiro Awhin, Ibobo Mike Enemuwe et autres

Nigéria (code pays fourni par la source)

In-silico Estimation of Flavonoids through Molecular Docking and Assessment of ADMET properties as DPP-IV inhibitor in the treatment of Diabetes Mellitus

Ejiro ProsperAwhin, I. Onosakponome, Alfred Ikechukwu Ajo, A.O. Isoje et autres

ChitinThe present study was carried out to extract and characterize chitin from selected mollusk (periwinkles, oysters, cowries, and water snails) shell wastes. The extraction of chitin from the shells of the selected mollusks was carried out by the chemical method. The characterization …

Nigéria (code pays fourni par la source)

Association between educational attainment and mental health conditions among Africans working and studying in selected African countries

Tshubelela Sello Simon Magakwe, Eme Eseme John, Edith Daniel-Nwosu, Osamudiamen McHillary Ogiemudia et autres

Mental health disorders, including depression, anxiety, and stress, are a growing global public health concern, with their prevalence influenced by various sociodemographic and contextual factors. Among these, the role of educational attainment in shaping mental health outcomes has received limited attention, particularly …

Afrique du Sud, au, Nigéria, Malawi, Mozambique, us, tt (code pays fourni par la source)

Cascading effects of malaria on hepatic function and gut microbiota: Investigating the prospective therapeutic utility of Phyllanthus amarus alkaloid extract

Innocent Onyesom, Chinwendu Obogheneophruhe Elu, U. E. Uzuegbu, Cyril Chuckwudi Dunkwu

Malaria remains a critical global health challenge, not only due to its parasitic burden but also because of its capacity to induce severe hepatic dysfunction and disrupt gut microbiota, which together aggravate disease outcomes. In this study, we employed a murine model …

Nigéria (code pays fourni par la source)

Knowledge and attitude to dietary regimen among patients with type 2 diabetes mellitus: implication for glycemic control

Mary Isioma Ofili, U. E. Uzuegbu, Bartholomew Chukwuebuka Nwogueze, Clinton Ulakpa

Nigéria (code pays fourni par la source)

In-vitro Anti-inflammatory and Antioxidant Potentials of Methanol Extract of Uvaria chamae (Bush Banana) Leaves

Godfrey R. Kwek, Anthony Orhu, U. E. Uzuegbu, Okeroghene S. Iwhiwhu et autres

Plants existence is pivotal for human survival, they do not only serve as a source of foliage and economic value but also provide an alternative source of medicine in combating various metabolic disorders. The preliminary investigation of the bioactive composition, in-vitro antioxidant, …

us, Nigéria, ye (code pays fourni par la source)

Nutriphytochemical Profiling and Changes in Cardiovascular Risk Index in Malarial Infected Mice Treated with Ethanol Root Extract of Phyllanthus Amarus

Adefunke Olukemi Opajobi, U. E. Uzuegbu, Ajala Michael Olawale, Pere-Ebi Yabrade Toloyai et autres

Purpose: The use of medicinal plants in malarial treatment has become popular in Nigeria, an endemic country, due to failing chemotherapy and high cost of antimalarial drugs. One of such commonly used herbs is Phyllanthus amarus. The antimalarial activity of P. amarus …

Nigéria (code pays fourni par la source)

Evaluation of erythrocyte viability, antioxidant capacity and antiplasmodial activity induced by alkaloid extract of Phyllanthus amarus

U. E. Uzuegbu, Innocent Onyesom, Adefunke Olukemi Opajobi, Chinwendu Obogheneophruhe Elu

Introduction: The production of large amounts of reactive oxygen species in severe malarial infection is due to parasite invasion to erythrocytes. Malaria resistance to medication has left malaria-endemic countries with no alternate source of medications but traditional medicine. One of such plants …

Nigéria (code pays fourni par la source)

Antiplasmodial Activity of Phyllanthus amarus and Associated Impact on Surrogate Markers of Insulin Sensitivity and Resistance Indices

Adefunke Olukemi Opajobi, U. E. Uzuegbu, Chinwendu Obogheneophruhe Elu, Pere-Ebi Yabrade Toloyai et autres

The antimalarial activity of different parts (leaf, fruit, stem, and root) of Phyllanthus amarus and their associated impact on surrogate markers of insulin sensitivity in experimental mice, having ascertained their toxicity (LD50) index were documented. Results showed that the plant parts were …

Nigéria (code pays fourni par la source)

Inhibition of Plasmodium berghei growth by alkaloid extract of Phyllanthus amarus in mice increased haem level and stabilized erythrocyte membrane

Adefunke Olukemi Opajobi, Evelyn Tarela Ojugbeli, U. E. Uzuegbu, Chinwendu Obogheneophruhe Elu et autres

Objectives: The Plasmodium parasite is known for its ability to destabilize the red cell membrane causing the release of free haem which is converted to haemozoin as haem is toxic to parasite. In combination with other factors, accumulation of haemozoin is associated …

Nigéria (code pays fourni par la source)

Determination of Antibacterial Evaluation, Phytochemical Screening and Ascorbic Acid Assay of Turmeric (Curcuma longa)

M. Oghenejobo, O. A. Opajobi, U. S. Oghenejobo Bethel, U. E. Uzuegbu

Using the agar well diffusion method, the microbial susceptibility of an ethanolic extract of Turmeric (Curcuma longa) was tested. The extract was found to be active against the bacteria used as it inhibited all the organisms with the highest inhibition zone of …

Nigéria (code pays fourni par la source)

Brain Levels of Reduced Glutathione and Malondialdehyde in Honey-Fed Wistar Rats

Prosper Ejiro Awhin, U. E. Uzuegbu, Evelyn Tarela Ojugbeli, Lily O. Otomewo

This research sought to verify the effect of natural honey on brain levels of malondialdehyde (MDA) and reduced glutathione (GSH) in rats. Forty nine male and female Wistar rats were used for the experiment. The rats were allotted into seven groups of …

Nigéria (code pays fourni par la source)