In-vitro Anti-inflammatory and Antioxidant Potentials of Methanol Extract of Uvaria chamae (Bush Banana) Leaves

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Plants existence is pivotal for human survival, they do not only serve as a source of foliage and economic value but also provide an alternative source of medicine in combating various metabolic disorders. The preliminary investigation of the bioactive composition, in-vitro antioxidant, and anti-inflammatory properties of methanol extract of Uvaria chamae leaves was evaluated in this study. The antioxidant activities were assessed using four various assays; Nitric oxide (NO) and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activities, Reducing power (RP), and Total antioxidant capacity (TOAC). In-vitro anti-inflammatory potentials were quantified using membrane stabilization, albumin denaturing test, and protease inhibitor test in addition to qualitative and quantitative plant phytochemical assays. The result obtained detected the presence of phenol, flavonoids, alkaloids, terpenes, and tannins from the qualitative phytochemistry. However, Flavonoid recorded the highest concentration of 1.21mg/gCAE while the least was alkaloid 0.41mg/gATE. The in-vitro antioxidant and anti-inflammatory activities of the extract showed a significant (p<0.05) increase in the activities of the extract in a concentration-dependent manner, while the respective IC50 values showed that the extracts obtained higher values in comparison (p<0.05) to the respective standard for the antioxidant activities. Conversely, the extract IC50 values for the anti-inflammatory activities were lower when compared (p<0.05) to the aspirin. The results of these investigations, suggest that Uvaria. chamae leave methanol extracts have antioxidant and anti-inflammatory properties. The mechanism of action may be due to its high content of flavonoids, which are known to inhibit membrane lysis, denaturation of albumin, and the activity of proteases. This study supports the utilization of Uvaria .chamae in folk medicine.

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