In-silico Estimation of Flavonoids through Molecular Docking and Assessment of ADMET properties as DPP-IV inhibitor in the treatment of Diabetes Mellitus
Rattachement africain : Nigéria. Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
ChitinThe present study was carried out to extract and characterize chitin from selected mollusk (periwinkles, oysters, cowries, and water snails) shell wastes. The extraction of chitin from the shells of the selected mollusks was carried out by the chemical method. The characterization of extracted chitin was carried out using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), and Scanning electron microscopy (SEM). The chitin yield from these shells ranged from 57.95 % to 70.9 % on a dry-weight basis. Analyses using XRD, FT-IR, and SEM confirmed that the chitin obtained was of the α-form. Using XRD, the extracted chitin’s crystallite size and crystallinity index varied between 29.16 nm and 40.8 nm, and 16.73% to 44.36%, respectively. FTIR analysis revealed characteristic peaks at 1684.8 cm⁻¹ (C=O stretching, amide I) and 1785.4 cm⁻¹ (C=O stretching in the NHCOCH₃ group). SEM images showed a rough surface texture and a fibre-like structure of the extracted chitin. These findings indicate that the α-chitin produced can enhance mechanical interlocking, when used in composite materials, potentially enhancing bonding with substances. The findings of this study suggest that chitin is not only abundant in mollusk shell wastes, but the obtained chitin also possesses favourable structural properties for various applications.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- In-silico Estimation of Flavonoids through Molecular Docking and Assessment of ADMET properties as DPP-IV inhibitor in the treatment of Diabetes Mellitus
- Date Crossref
- 22/08/2025
- Éditeur
- Manuscript Technomedia LLP
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Delta State University Department of Medical Biochemistry Nigéria (code pays fourni par la source)Université ou école supérieure
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Western Delta University Nigéria (code pays fourni par la source)Université ou école supérieure
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University of Nigeria Department of Biochemistry Nsukka, Nigéria (code pays fourni par la source)Université ou école supérieure
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Dennis Osadebay University Department of Biochemistry and Molecular Biology Nigéria (pays nommé en fin d’affiliation)Université ou école supérieure
Department of Medical Biochemistry — Delta State University (Nigéria), Western Delta University (Nigéria) et Department of Biochemistry — University of Nigeria (Nsukka, Nigéria), avec 1 autre affiliation. Pays d’affiliation : Nigéria.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.