Accès ouvert
2026
article
OpenAlex
Chunyan Luan, Anja Wessely, Zhesi Zhang, Liang Zhang et autres
SOX10 is essential for melanocyte development and maintenance and plays a critical role in uveal melanoma (UM) initiation and progression. While SOX10's transcriptional regulation of protein-coding genes is well characterized, its role on microRNA (miRNA) regulatory landscape in UM remains unexplored. Here, …
de, fi
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Accès ouvert
2026
article
OpenAlex
Adrian Weich, Christopher Lischer, Julio Vera
SUMMARY: Long-read DNA sequencing is increasingly applied for whole-genome studies, yet experimental planning often lacks reliable estimates of target region coverage, leading to costly and time-consuming pilot studies and replicates. We present esloco, a Monte Carlo-based simulation framework for estimating local coverage …
de
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Accès ouvert
2025
preprint
OpenAlex
Chunyan Luan, Anja Wessely, Z.J. Zhang, Liang Zhang et autres
Abstract SOX10 is essential for melanocyte development and maintenance and plays a critical role in uveal melanoma (UM) initiation and progression. While SOX10’s transcriptional regulation of protein-coding genes is well characterized, its role on microRNA (miRNA) regulatory landscape in UM remains unexplored. …
de, fi
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Anja Wessely, Christopher Lischer, Adrian Weich, Claudia Kammerbauer et autres
Abstract Uveal melanoma (UM) is the most common intraocular malignancy in adults. In contrast to cutaneous melanoma (CM), effective treatment options for metastatic UM are limited. The transcription factor SOX10 is crucial for CM initiation and survival, making it an interesting candidate …
de, us, fi
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Accès ouvert
2025
article
OpenAlex
Adrian Weich, Johannes Berges, Cindy Flamann, Katrin Bitterer et autres
BACKGROUND: The metastatic microenvironment is often rich in tumor-associated macrophages (TAMs). In uveal melanoma (UM), high levels of TAMs positively correlate with tumor progression and poorer prognosis. We hypothesize that the immunomodulation of TAMs can remodel the UM tumor microenvironment and make …
de, fi
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Accès ouvert
2024
article
OpenAlex
Christopher Lischer, Martin Eberhardt, Cindy Flamann, Johannes Berges et autres
BACKGROUND: Tumor-associated antigens and their derived peptides constitute an opportunity to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. A performant and rational antigen selection pipeline would lay the foundation for immunotherapy trials with the potential to …
de, nl
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Accès ouvert
2024
preprint
OpenAlex
Adrian Weich, Cindy Flamann, Johannes Berges, Krishna P. Singh et autres
Abstract Background Uveal melanoma (UM) is a highly malignant intraocular tumor with a poor prognosis and response to therapy, including immune checkpoint inhibitors (ICIs), after the onset of liver metastasis. The metastatic microenvironment contains high levels of tumor-associated macrophages (TAMs) that correlate …
de, fi
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Accès ouvert
2023
preprint
OpenAlex
Christopher Lischer, Martin Eberhardt, Adrian Weich, Julio Vera
Abstract Tumor-associated antigens (TAAs) and their derived peptides constitute the chance to design off-the-shelf mainline or adjuvant anti-cancer immunotherapies for a broad array of patients. Here, we present a computational pipeline that selects and ranks candidate antigens in a multi-pronged approach and …
de
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Accès ouvert
2021
article
OpenAlex
Tatjana Sauerer, Christopher Lischer, Adrian Weich, Carola Berking et autres
Merkel cell carcinoma (MCC) is a rare and highly aggressive cancer, which is mainly caused by genomic integration of the Merkel cell polyomavirus and subsequent expression of a truncated form of its large T antigen. The resulting primary tumor is known to …
de
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