Lucia Dican

Copper Complexes: Main Mechanisms as Anticancer Agents

Adriana Corina Hangan, Luminita Simona Oprean, Lucia Maria Procopciuc, Lucia Dican et autres

Copper is an essential element for living organisms, being a cofactor for numerous enzymes or proteins involved in oxidation-reduction reactions, intervening in numerous metabolic processes. In recent decades, complex copper combinations have consolidated their position in medicinal chemistry, which is manifested by …

ro (code pays fourni par la source)

HLA Diversity in Transylvanian Ethnic Groups: Consequences for Hematopoietic Cell Transplantation

Lucia Dican, Mihaela Iancu, Florin Ioan Elec, Dan Burghelea et autres

The HLA profile is essential in cell and tissue transplantation, particularly in patients with autoimmune conditions and infections. Due to the extreme polymorphism in certain HLA loci, it also serves as a key tool for population genetic analysis. This study aimed to …

ro (code pays fourni par la source)

Metal-Based Drug–DNA Interactions and Analytical Determination Methods

Adriana Corina Hangan, Luminita Simona Oprean, Lucia Dican, Lucia Maria Procopciuc et autres

DNA structure has many potential places where endogenous compounds and xenobiotics can bind. Therefore, xenobiotics bind along the sites of the nucleic acid with the aim of changing its structure, its genetic message, and, implicitly, its functions. Currently, there are several mechanisms …

ro (code pays fourni par la source)

Human Leukocyte Antigen and microRNAs as Key Orchestrators of Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review

Cristina-Sorina Cătană, Monica Mihaela Marta, Mădălina Văleanu, Lucia Dican et autres

The expression of inflamma-miRs and human leukocyte antigen (HLA) haplotypes could indicate mild cognitive impairment (MCI) and Alzheimer’s disease (AD). We used international databases to conduct a systematic review of studies on HLA variants and a meta-analysis of research on microRNAs (miRNAs). …

ro (code pays fourni par la source)

Orchestrating the Impact of KIR/HLA Interactions on Kidney Transplant

Luminița-Ioana Iancu Loga, Ramona Suharoschi, Florin Ioan Elec, Alin Dan Chiorean et autres

This study examines the interplay between human leukocyte antigen (HLA) compatibility and killer-cell immunoglobulin-like receptor (KIR) genotypes in influencing kidney transplantation outcomes. Understanding these interactions is crucial for improving graft survival and minimizing rejection risks. We evaluated 84 kidney transplant recipients, dividing …

ro (code pays fourni par la source)

HLA and microRNAs as key orchestrators of mild cognitive impairment and Alzheimer’s disease

Cristina-Sorina Cătană, Monica Mihaela Marta, Mădălina Văleanu, Lucia Dican et autres

microRNAs, biomarkers, neuroinflammation.

ro (code pays fourni par la source)

HLA Class II Allele Groups Involved in Autoimmune Thyroid Diseases: Hashimoto’s Thyroiditis and Basedow–Graves Disease

Alin-Dan Chiorean, Gheorghe Zsolt Nicula, Ștefana Bâlici, Mihaela Laura Vică et autres

Autoimmune thyroid diseases (AITD), particularly Hashimoto’s thyroiditis (HT) and Basedow–Graves disease (BGD) are diseases of global public health concern, characterized by autoimmune attacks on the thyroid gland, leading to hypothyroidism in HT and hyperthyroidism in BGD. We conducted a study between 2019 …

ro (code pays fourni par la source)

Biologically Active Metallic Cu(II) Complexes in Cancer: Past, Present, and Future

Adriana Corina Hangan, Luminita Simona Oprean, Bogdan Sevastre, Lucia Maria Procopciuc et autres

ro (code pays fourni par la source)

New Copper Complexes with Antibacterial and Cytotoxic Activity

Adriana Corina Hangan, Roxana Liana Lucaciu, Alexandru Turza, Lucia Dican et autres

The discovery of a new non-toxic metal complex with biological activity represents a very active area of research. Two Cu+2 complexes, [Cu4(L1)4(OH)4(DMF)2(H2O)] (C1) (HL1 = N-(5-ethyl-[1,3,4]–thiadiazole–2-yl)-benzenesulfonamide) and [Cu(L2)2(phen)(H2O)] (C2) (HL2 = N-(5-(4-methylphenyl)-[1,3,4]–thiadiazole–2-yl)-naphtalenesulfonamide), with two new ligands were synthesized. The X-ray crystal structures …

ro (code pays fourni par la source)

Association between Human Leukocyte Antigen and End-Stage Renal Disease in Patients from Transylvania, Romania

Luminița-Ioana Iancu Loga, Lucia Dican, Alin Dan Chiorean, Vlad-Florin Chelaru et autres

End-stage renal disease (ESRD) is the final stage of chronic kidney disease. This study explored the association between human leukocyte antigen (HLA) and ESRD. The interaction between genetic and environmental factors may also play a role in the development of ESRD. The …

ro (code pays fourni par la source)

KIR Analysis in Context of Kidney Transplantation

Gabriel Cristian Dragomir-Loga, Lucia Dican

NK cells express activating and inhibitory killer cell immunoglobulin-like receptors (KIR). We analyzed the KIR genotypes in patients with kidney transplant and in healthy donor. We studied KIR in 84 Kidney transplant patients and 97 voluntary blood donors of stem cells. We …

ro (code pays fourni par la source)

Relevant biomarkers of kidney allograft rejection

Luminita Ioana Loga, Lucia Dican, Horea Vladi Matei, Ion Mărunțelu et autres

This review focuses on the new relevant biomarkers proposed for the diagnosis of different types of allograft rejections. The immune response against the transplanted tissues can lead to rejection. Kidney allograft rejection occurs when the recipient component's immune system reacts against the …

ro (code pays fourni par la source)