Orchestrating the Impact of KIR/HLA Interactions on Kidney Transplant
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Le résumé fourni par la source
This study examines the interplay between human leukocyte antigen (HLA) compatibility and killer-cell immunoglobulin-like receptor (KIR) genotypes in influencing kidney transplantation outcomes. Understanding these interactions is crucial for improving graft survival and minimizing rejection risks. We evaluated 84 kidney transplant recipients, dividing them into two groups based on post-transplant outcomes: there were 68 with stable graft function (SGF) and 16 who experienced chronic rejection (CR). Patients were selected based on specific inclusion criteria. HLA mismatches (Class I: HLA-A, -B; Class II: HLA-DR) and KIR genotypes were determined using standard genotyping techniques. Statistical analyses, including logistic regression, were performed to correlate these factors with transplant outcomes. Significant age differences were observed, with younger patients more likely to experience graft rejection, while no significant gender-based differences were noted. A significant correlation was found between Class II mismatches and increased rejection rates, highlighting the importance of HLA-DR compatibility. Further analysis revealed that certain inhibitory KIRs, such as KIR3DL1, were associated with favorable outcomes, suggesting a protective role against graft rejection. These findings were corroborated by evaluating serum creatinine levels over multiple years, serving as a biomarker for renal function post transplant. This study underscores the critical need for meticulous HLA matching and the consideration of KIR genotypes in pre-transplant evaluations to enhance graft survival and minimize rejection risks. Integrating these genetic factors into routine clinical assessments could significantly improve personalized transplant medicine strategies, ultimately enhancing patient outcomes. Further research is needed to explore the underlying mechanisms and validate these findings in larger, diverse populations.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Orchestrating the Impact of KIR/HLA Interactions on Kidney Transplant
- Date Crossref
- 28/07/2024
- Éditeur
- MDPI AG
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Iuliu Hațieganu University of Medicine and Pharmacy pays non établi dans la noticeUniversité ou école supérieure
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Institutul Clinic de Urologie și Transplant Renal Cluj pays non établi dans la noticeÉtablissement de santé
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University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca pays non établi dans la noticeUniversité ou école supérieure
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Clinical Institute of Urology and Renal Transplantation pays non établi dans la noticeStructure de recherche
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Faculty of Medicine Department of Cellular and Molecular Biology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Food Science and Technology pays non établi dans la noticeUniversité ou école supérieure
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“Iuliu-Hațieganu” University of Medicine and Pharmacy Department of Anesthesiology pays non établi dans la noticeUniversité ou école supérieure
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Faculty of Pharmacy Department of Pharmaceutical Biochemistry and Clinical Laboratory pays non établi dans la noticeUniversité ou école supérieure
Iuliu Hațieganu University of Medicine and Pharmacy, Institutul Clinic de Urologie și Transplant Renal Cluj et University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca, avec 5 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.