Accès ouvert
2026
article
OpenAlex
Lucia Maria Procopciuc, Adriana Corina Hangan, Sidonia Gog-Bogdan, Roxana Liana Lucaciu
Depression and Alzheimer’s disease are among the most prevalent and disabling disorders worldwide, imposing a substantial social, economic, and healthcare burden. Increasing evidence suggests that these conditions share several pathophysiological mechanisms, including chronic inflammation, oxidative stress, mitochondrial dysfunction, altered neurotransmission, and gut …
ro
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Accès ouvert
2026
article
OpenAlex
Rahela Borbei, Vlad Dumitru Brata, Ioana Dobrotă, Ligia-Maria Ceteraș et autres
Metabolic syndrome (MetS) is a composite classification defined by heterogeneous combinations of cardiometabolic abnormalities. Several components have been associated with pancreatic cancer (PC), but studies often conflate long-term metabolic exposure, tumor-related prediagnostic metabolic change, and prognosis after diagnosis. This review critically evaluates …
ro
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Accès ouvert
2026
article
OpenAlex
Crina Veronica Zinveliu (Bercian), Dan Claudiu Măgureanu, Raluca Maria Pop, Adela Sitar-Tăut et autres
Oxidative stress and systemic inflammation are considered key mechanisms linking obstructive sleep apnea (OSA) to cardiovascular disease. This study aimed to investigate the relationships among oxidative stress, nitrosative stress, inflammatory biomarkers, and echocardiographic alterations in OSA. This cross-sectional observational study included 72 …
ro
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Accès ouvert
2026
article
OpenAlex
Lucia Maria Procopciuc, Adriana Corina Hangan, Roxana Liana Lucaciu
Metabolic syndrome (MetS) is a multifactorial disorder characterized by central obesity, insulin resistance, dyslipidemia, hypertension, and impaired glucose metabolism, significantly increasing the risk of type 2 diabetes and cardiovascular disease. Recent evidence highlights the important role of the gut-brain axis in the …
ro
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Accès ouvert
2026
editorial
OpenAlex
Lucia Maria Procopciuc, Adriana Corina Hangan, Roxana Liana Lucaciu
Metabolic syndrome (MetS) represents one of the most important global health challenges of the twenty-first century [...].
ro
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Accès ouvert
2026
article
OpenAlex
Lucia Maria Procopciuc, Gabriela Valentina Caracostea, Adriana Corina Hangan, Roxana Liana Lucaciu
During pregnancy, hormonal, metabolic, and immunological changes influence the composition and function of maternal microbial communities. Increasing evidence suggests that the maternal microbiota—particularly in the vaginal, gut, and oral environments—plays a significant role in maintaining pregnancy homeostasis and supporting fetal development. In …
ro
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Accès ouvert
2026
review
OpenAlex
Crina Veronica Zinveliu (Bercian), Adela Sitar-Tăut, Angela Cozma, Elena Buzdugan et autres
Obstructive sleep apnea (OSA) constitutes a chronic disorder characterized by recurrent upper airway collapse during sleep. This condition is prevalent among patients with cardiac rhythm disturbances and represents a potent independent risk factor for arrhythmia. Although most studies have concentrated on the …
ro
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Accès ouvert
2026
article
OpenAlex
Lucia Maria Procopciuc, Adrina Corina Hangan, Roxana Liana Lucaciu
Colorectal cancer (CRC) is a multifactorial disease arising from dynamic interactions between gut microbiota, inflammatory processes, metabolic reprogramming, and dysregulated host signaling pathways. Increasing evidence highlights the potential of synbiotics-combinations of probiotics and prebiotics-as promising modulators of these processes. This review explores …
ro
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Accès ouvert
2026
article
OpenAlex
Lucia Maria Procopciuc, Gabriela Valentina Caracostea, Adriana Corina Hangan, Roxana Liana Lucaciu
Preeclampsia is a pregnancy-specific multisystem disorder and a major cause of maternal and perinatal morbidity and mortality worldwide. This narrative review summarizes current evidence on the principal risk factors and pathophysiological mechanisms involved in its development. The disease is best explained by …
ro
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2026
article
OpenAlex
Mihai Surcel, Mihaela Iancu, Ioana Cristina Rotar, Iulian Gabriel Goidescu et autres
Background and Objectives: Adenomyosis is increasingly being recognized as a heterogeneous uterine disorder with variable clinical expressions. Current ultrasound-based classifications do not consistently align structural severity with symptom burden. Given its role in angiogenesis, inflammation, and endometrial remodeling, vascular endothelial growth factor …
ro
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Accès ouvert
2026
article
OpenAlex
Adriana Corina Hangan, Luminita Simona Oprean, Lucia Maria Procopciuc, Lucia Dican et autres
Copper is an essential element for living organisms, being a cofactor for numerous enzymes or proteins involved in oxidation-reduction reactions, intervening in numerous metabolic processes. In recent decades, complex copper combinations have consolidated their position in medicinal chemistry, which is manifested by …
ro
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Accès ouvert
2026
article
OpenAlex
Melinda Baizat, Mihaela Iancu, Gabriela Corina Zaharie, Monica G. Hăşmăşanu et autres
(1) Background: Neonatal sepsis continues to be one of the leading causes of mortality and morbidity, particularly in underdeveloped countries. We aimed to compare laboratory parameters between clinical early-onset sepsis (clinEOS) and NNNon-clinEOS groups and to evaluate the association between TLR2-Arg753Gln, TLR4-Asp299Gly, …
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