Anthony T. Blikslager

A specific cause of recurrent colic highlights some common themes among horses with intermittent colic

Anthony T. Blikslager

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Abdominal palpation per rectum is highly sensitive for identifying small versus large intestinal lesions in horses presenting for colic

Mary Hallsten, Callie Fogle, Sarah Shippy, Kallie J. Hobbs et autres

Objective: To describe the sensitivity, specificity, predictive values, and accuracy of abdominal palpation per rectum in horses treated surgically for colic. Methods: Medical records were gathered over 5 years (2019 to 2024). Findings of abdominal palpation per rectum were collected and compared …

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A novel dataset of 2,362 equine fecal microbiomes from veterinary teaching hospitals across three countries reveals effects of geography and disease

Zachary L. McAdams, Emma Joanne Campbell, Rebecca A. Dorfmeyer, Giedre Turner et autres

BACKGROUND: Horses and other equids are reliant on the gut microbiome for health, and studies have reported associations between certain clinical conditions and features of the fecal microbiome. However, research to date on the equine fecal microbiome has often relied on small …

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Lactate and colic–Shetland ponies as an example of one size does not fit all

Anthony T. Blikslager

Summary The clinical commentary discusses the utility of peritoneal lactate alone, and in the context of other clinical factors, in determining the presence of a strangulating intestinal obstruction. A current study on Shetland ponies has revealed that peritoneal lactate well outside the …

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Mo1337: ROLE OF MAST CELLS AND CORRELATION OF SYSTEMIC CD4 T-CELL ACTIVTATION WITH ESOPHAGEAL EOSINOPHIL INFILTRATION IN A PORCINE MODEL OF EOSINOPHILIC ESOPHAGITIS

Lizette M. Corets, Tobias Käser, Joshua B. Wechsler, Anthony T. Blikslager et autres

Comparison of histochemical methods for the analysis of eosinophils and mast cells using a porcine model of eosinophilic esophagitis

David K. Meyerholz, Douglas B. Snider, Akash Karri, Glenn Cruse et autres

Accurate identification of eosinophils in tissue sections is required for diagnosis of eosinophilic esophagitis in humans and the assessment of severity of disease in allergy models. The pig may be a good model for sensitization and allergy models due to anatomical, physiological, …

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Comparison of histochemical methods for the analysis of eosinophils and mast cells using a porcine model of eosinophilic esophagitis

Douglas B. Snider, David K. Meyerholz, Evan S. Dellon, Lizette M. Cortes et autres

Introduction: Accurate identification of eosinophils in tissue sections is required for diagnosis of eosinophilic esophagitis in humans and the assessment of severity of disease in allergy models. The pig may be a good model for sensitization and allergy models due to anatomical, …

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Single-cell transcriptomics predict novel potential regulators of acute epithelial restitution in the ischemia-injured intestine

Elizabeth C. Rose, Jeremy M. Simon, Ismael Gomez-Martinez, Scott T. Magness et autres

These studies validate an approach to identify and predict upstream regulation of restituting epithelium in a unique pig intestinal ischemic injury model. Identification of potential molecular mediators of restitution, such as CSF-1, will inform the development of targeted therapeutic interventions for the …

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A novel dataset of 2,362 equine fecal microbiomes from eight veterinary teaching hospital on three continents reveals dominant effects of geography, breed, and disease

Zachary L. McAdams, Emma Joanne Campbell, Rebecca A. Dorfmeyer, Giedre Turner et autres

Abstract Horses and other equids are reliant on the gut microbiome for health, and studies have reported associations between certain clinical conditions and features of the fecal microbiome. However, research to date on the equine fecal microbiome has often relied on small …

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Equine Enteric Glial Culture and Application to the Study of A Neural Inflammatory Mechanism in Equine Colic

Emily Hellstrom, Caroline McKinney-Aguirre, Liara M. Gonzalez, Amanda L. Ziegler et autres

Inflammatory postoperative conditions of equine colic (acute abdomen) contribute not only to increased client cost, patient discomfort, and hospitalization time, but in many cases, prove to be life-threatening. A unique population of intestinal cells, enteric glia, are increasingly acknowledged for their roles …

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Trends in the management of horses referred for colic evaluation preceding and during the COVID ‐19 pandemic (2013–2023)

George L. Elane, Anthony T. Blikslager, Tim Mair

Background: The COVID-19 pandemic represented a significant source of anxiety and stress for equine veterinarians and clients, with the potential for measurable effects on caseload and owner economics. Objective: To compare the number of horses presenting for emergency colic evaluation and treatment, …

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Single-cell transcriptomics predict novel potential regulators of acute epithelial restitution in the ischemia-injured intestine

Elizabeth C. Rose, Jeremy M. Simon, Ismael Gomez-Martinez, Scott T. Magness et autres

ABSTRACT Intestinal ischemic injury damages the epithelial barrier predisposes patients to life-threatening sepsis unless that barrier is rapidly restored. There is an age-dependency of intestinal recovery in that neonates are the most susceptible to succumb to disease of the intestinal barrier versus …

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