Glenn Cruse

Nanosilver composite pNIPAm microgels for the development of antimicrobial platelet‐like particles

Andrew D. Bond, Glenn Cruse, Landon Morrill, Emily Mihalko et autres

Platelets crucially facilitate wound healing but can become depleted in traumatic injury or chronic wounds. Previously, our group developed injectable platelet-like particles (PLPs) comprised of highly deformable, ultralow crosslinked pNIPAm microgels (ULCs) coupled to fibrin binding antibodies to treat post-trauma bleeding. PLP …

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Corrigendum to ‘Round Window Membrane Extracellular Vesicles Facilitate Inner Ear Drug Delivery’ [Journal of Controlled Release 387 (2025) 114153].

S Holdsclaw, Dylan Silkstone, Farimah Moazzam, H Jeanneret et autres

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Round window membrane extracellular vesicles facilitate inner ear drug delivery

S Holdsclaw, Dylan Silkstone, Farimah Moazzam, H Jeanneret et autres

Hearing loss affects over 430 million people worldwide, yet effective treatments remain limited, in part due to challenges of inner ear drug delivery, a process that is risky, unreliable, and inefficient. Addressing this challenge calls for delivery approaches that ensure therapies reach …

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Evolution of mast cell research associated with the Laboratory of Allergic Diseases, 1985-2022: Summary of the 2023 NIAID Symposium

Hirsh D. Komarow, Gunnar Nilsson, Yoshimichi Okayama, Yoseph A. Mekori et autres

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Comparison of histochemical methods for the analysis of eosinophils and mast cells using a porcine model of eosinophilic esophagitis

David K. Meyerholz, Douglas B. Snider, Akash Karri, Glenn Cruse et autres

Accurate identification of eosinophils in tissue sections is required for diagnosis of eosinophilic esophagitis in humans and the assessment of severity of disease in allergy models. The pig may be a good model for sensitization and allergy models due to anatomical, physiological, …

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Comparison of histochemical methods for the analysis of eosinophils and mast cells using a porcine model of eosinophilic esophagitis

Douglas B. Snider, David K. Meyerholz, Evan S. Dellon, Lizette M. Cortes et autres

Introduction: Accurate identification of eosinophils in tissue sections is required for diagnosis of eosinophilic esophagitis in humans and the assessment of severity of disease in allergy models. The pig may be a good model for sensitization and allergy models due to anatomical, …

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Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice

Karl G. Schuchard, Kristen D. Popowski, Sandip Akunuri, Matias Tenorio et autres

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Exon Skipping of FcεRIβ for Allergic Diseases

Greer Arthur, Glenn Cruse

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Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

S. L. Tilley, William C Bennett, Ilona Jaspers, Brandon T. Oby et autres

Ozone is a highly reactive environmental pollutant with well-recognized adverse effects on lung health. Bronchial hyperresponsiveness (BHR) is one consequence of ozone exposure, particularly for individuals with underlying lung disease. Our data demonstrated that ozone induced substantial ATP release from human airway …

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Antihistamine Medication Blunts Localized-Vibration-Induced Increases in Popliteal Blood Flow

Devin Needs, Jonathan D. Blotter, Gilbert W. Fellingham, Glenn Cruse et autres

Localized vibration (LV) of the lower leg increases arterial blood flow (BF). However, it is unclear how LV causes this increase. Understanding the mechanisms of this response could lead to the optimized future use of LV as a therapy. One possible mechanism …

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Low-dose intrapulmonary drug delivery device for studies on next-generation therapeutics in mice

Ana M. Gracioso Martins, Douglas B. Snider, Kristen D. Popowski, Karl G. Schuchard et autres

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The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis

Barry A. Hedgespeth, Douglas B. Snider, Katie J. Bitting, Glenn Cruse

Introduction: Anaphylaxis represents the most extreme and life-threatening form of allergic disease and is considered a medical emergency requiring immediate intervention. Additionally, some people with mastocytosis experience recurrent episodes of anaphylaxis during normal daily activities without exposure to known triggers. While acute …

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