Matthieu Lépine

Role of Amniotic Fluid Toxicity in the Pathophysiology of Myelomeningocele: A Narrative Literature Review

Yoann Athiel, Jean‐Marie Jouannic, Matthieu Lépine, Corentin Maillet et autres

Myelomeningocele is a birth defect whose clinical manifestations are due both to incomplete neural tube closure and the progressive destruction of exposed neuroepithelium during pregnancy. Two hypotheses have been formulated to explain the spinal cord damage in utero: mechanical trauma and chemical …

fr (code pays fourni par la source)

Self‐Organization of Long‐Lasting Human Endothelial Capillary‐Like Networks Guided by DLP Bioprinting (Adv. Healthcare Mater. 14/2024)

Elsa Mazari‐Arrighi, Matthieu Lépine, Dmitry Ayollo, Lionel Faivre et autres

Bioengineered Capillary Networks Digital Light Processing bioprinting is used to guide primary endothelial progenitor cell self-organization over light-cured hydrogel scaffolds, producing capillary-like branched vascular structures which are stable for weeks, with promising applications in tissue engineering. More details can be found in …

Self‐Organization of Long‐Lasting Human Endothelial Capillary‐Like Networks Guided by DLP Bioprinting

Elsa Mazari‐Arrighi, Matthieu Lépine, Dmitry Ayollo, Lionel Faivre et autres

Tissue engineering holds great promise for regenerative medicine, drug discovery, and as an alternative to animal models. However, as soon as the dimensions of engineered tissue exceed the diffusion limit of oxygen and nutriments, a necrotic core forms leading to irreversible damage. …

fr (code pays fourni par la source)

Self-organization of Long-lasting Human Endothelial Capillary Networks guided by DLP Bioprinting

Elsa Mazari‐Arrighi, Matthieu Lépine, Dmitry Ayollo, Lionel Faivre et autres

ABSTRACT Tissue engineering holds great promise for regenerative medicine, drug discovery and as an alternative to animal models. However, as soon as the dimensions of engineered tissue exceed the diffusion limit of oxygen and nutriments, a necrotic core forms leading to irreversible …

fr, xk (code pays fourni par la source)

Parvalbumin interneuron-derived tissue-type plasminogen activator shapes perineuronal net structure

Matthieu Lépine, Sara Douceau, Gabrielle Devienne, Paul Prunotto et autres

BACKGROUND: Perineuronal nets (PNNs) are specialized extracellular matrix structures mainly found around fast-spiking parvalbumin (FS-PV) interneurons. In the adult, their degradation alters FS-PV-driven functions, such as brain plasticity and memory, and altered PNN structures have been found in neurodevelopmental and central nervous …

fr (code pays fourni par la source)

Modulation enzymatique des réseaux périneuronaux par la désintégrine et métalloprotéinase à motifs thrombospondines de type 4 (ADAMTS-4) et l'activateur tissulaire du plasminogène (tPA)

Matthieu Lépine

Les réseaux périneuronaux (perineuronal nets, PNNs) sont des structures de la matrice extracellulaire, qui enveloppent préférentiellement les interneurones exprimant la parvalbumine (PV). Ils régulent l’activité neuronale, protègent contre le stress oxydatif et ferment les périodes critiques du développement. La dégradation des PNNs …

fr (code pays fourni par la source)

Enzymatic modulation of perineuronal nets by a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) and the tissue plasminogen activator (tPA)

Matthieu Lépine

Les réseaux périneuronaux (perineuronal nets, PNNs) sont des structures de la matrice extracellulaire, qui enveloppent préférentiellement les interneurones exprimant la parvalbumine (PV). Ils régulent l’activité neuronale, protègent contre le stress oxydatif et ferment les périodes critiques du développement. La dégradation des PNNs …

fr (code pays fourni par la source)

Modulation enzymatique des réseaux périneuronaux par la désintégrine et métalloprotéinase à motifs thrombospondines de type 4 (ADAMTS-4) et l'activateur tissulaire du plasminogène (tPA)

Matthieu Lépine

Les réseaux périneuronaux (perineuronal nets, PNNs) sont des structures de la matrice extracellulaire, qui enveloppent préférentiellement les interneurones exprimant la parvalbumine (PV). Ils régulent l’activité neuronale, protègent contre le stress oxydatif et ferment les périodes critiques du développement. La dégradation des PNNs …

Impact of 12/15-Lipoxygenase on Brain Injury After Subarachnoid Hemorrhage

Thomas Gaberel, Clément Gakuba, Yi Zheng, Matthieu Lépine et autres

Background and Purpose- Subarachnoid hemorrhage (SAH) is a devastating form of stroke. Oxidative stress contributes to brain injury, but the mechanisms have been poorly studied. Here, we evaluated the role of 12/15-lipoxygenase (12/15-LOX), an enzyme known to cause cell death in ischemic …

us, fr (code pays fourni par la source)

ADAMTS‐4 in oligodendrocytes contributes to myelination with an impact on motor function

Mathilde Pruvost, Matthieu Lépine, Camille Leonetti, Olivier Etard et autres

Abstract Myelination is a late developmental process regulated by a set of inhibitory and stimulatory factors, including extracellular matrix components. Accordingly, chondroitin sulfate proteoglycans (CSPGs) act as negative regulators of myelination processes. A disintegrin and metalloproteinase with thrombospondin motifs type 4 (ADAMTS‐4) …

fr (code pays fourni par la source)

[Early detection of gynecologic neoplasms: value of lactate dehydrogenase in vaginal secretions as a tumor marker].

Calise K. Berger, Matthieu Lépine, M Meandzija, G Szalmay et autres

Involvement of the Nervous System in Non-Hodgkin’s Lymphomas

B Longpré, Jacques Lamarche, M Rochon, Matthieu Lépine

fr (code pays fourni par la source)