Accès ouvert
2026
article
OpenAlex
Benjamin Rath, Julian Wolfes, Christian Ellermann, Fatih Güner et autres
BACKGROUND: Mitral valve prolapse (MVP) is commonly benign, but an arrhythmic phenotype (AMVP) with increased risk for sudden cardiac death has been described. Current risk stratification is mainly based on clinical data and imaging markers, while the role of programmed ventricular stimulation …
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Accès ouvert
2026
article
OpenAlex
Julian Wolfes, Amy Katthöfer, Felix Wegner, Benjamin Rath et autres
Local anesthetics are widely used in medical care. However, their sodium channel blocking properties not only explain their analgesic potency but also their possible cardiotoxic effects. Due to the different pharmacodynamics and pharmacokinetics of different local anesthetics as well as the divergent …
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Accès ouvert
2026
article
OpenAlex
Benjamin Rath, Julian Wolfes, Christian Ellermann, Fatih Güner et autres
Abstract Background Mitral valve prolapse (MVP) is commonly benign, but an arrhythmic phenotype (AMVP) with increased risk for sudden cardiac death has been described. A prolonged T peak -T end interval has been association with increased arrhythmic risk in different clinical settings. …
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Accès ouvert
2025
article
OpenAlex
Hilke Könemann, A Camu, Antonius Büscher, Jan Sackarnd et autres
BACKGROUND: Antiarrhythmic drug therapy is a cornerstone in managing electrical storm (ES). Data on the safety and efficacy of antiarrhythmic drugs besides beta-blockers and amiodarone are limited. OBJECTIVE: This retrospective observational study aimed to assess the potential role of ajmaline in patients …
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Accès ouvert
2025
article
OpenAlex
Felix K. Wegner, Julian Wolfes, Benjamin Rath, Julia Köbe et autres
BACKGROUND: Smartwatches are increasingly used for screening of tachyarrhythmias and for ECG recording. We therefore investigated possible mechanisms of magnet-mode induction of smartwatches in cardiac implantable electronic devices (CIED). METHODS: Fifteen CIED (5 pacemakers, 10 implantable cardioverter-defibrillators) from all manufacturers were implanted …
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Accès ouvert
2025
article
OpenAlex
Fabienne Kreimer, Tobias Brix, Felix K. Wegner, Dennis Korthals et autres
Background/Objectives: Electrocardiographic (ECG) findings such as sinus tachycardia and right bundle branch block are commonly associated with acute pulmonary embolism (PE). This study aimed to investigate the prevalence of advanced interatrial block (IAB) in patients with acute PE and its association with …
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Accès ouvert
2025
article
OpenAlex
Sati Güler-Eren, Fatih Güner, Charleen-Therese Wanjek, Hilke Könemann et autres
Background: Takotsubo syndrome (TTS) is an acute cardiac condition characterized by transient left ventricular dysfunction. Although generally considered reversible, early arrhythmias are a dreaded complication and their prognostic significance remains incompletely understood. Methods: In this study, 104 consecutive patients diagnosed with TTS …
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Accès ouvert
2025
article
OpenAlex
Julian Wolfes, Felix K. Wegner, Benjamin Rath, Lars Eckardt et autres
Background: The two antiepileptic drugs lacosamide and lamotrigine exert their antiepileptic effect by inhibiting sodium channels. Lacosamide enhances the inactivation of sodium channels, while lamotrigine inhibits the activation of the channel. Interactions with sodium channels also play an interesting role in cardiac …
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Accès ouvert
2025
article
OpenAlex
Florian Doldi, Kevin Willy, Julian Wolfes, Christian Ellermann et autres
Background and Objective: Implantable Cardioverter Defibrillators (ICDs) are crucial in treating ventricular tachyarrhythmias (VTs) and preventing sudden cardiac death. However, ICD shocks are linked to higher mortality and a lower quality of life. Many patients suffer from recurrent VTs despite concomitant antiarrhythmic …
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Accès ouvert
2025
article
OpenAlex
Benjamin Rath, Julian Wolfes, Christian Ellermann, Fatih Güner et autres
Abstract Background In about 8% of survivors of sudden cardiac death, no structural or electrical heart disease can be identified. Some of these patients with idiopathic ventricular fibrillation (IVF) present ECG markers of early repolarization (Early Repolarization Syndrome, ERS). The T peak–T …
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Accès ouvert
2025
article
OpenAlex
Gerrit Frommeyer, Florian Reinke, Benjamin Rath, Julian Wolfes et autres
BACKGROUND: The subcutaneous implantable defibrillator (S-ICD) is an alternative to transvenous implantable defibrillators. The present analysis presents real-world data from patients with S-ICD and a follow-up duration of 10 years or more. METHODS AND RESULTS: Between July 2010 and November 2013 76 …
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Accès ouvert
2025
article
OpenAlex
Christian Ellermann, Carlo Mengel, Julian Wolfes, Felix K. Wegner et autres
Background: Recent studies reported an abbreviation of cardiac repolarization induced by sacubitril. Thus, the purpose of this study was to evaluate the electrophysiologic effects of sacubitril in the presence of drugs that shorten the QT interval. Methods and Results: 25 rabbit hearts …
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