Masayuki Inoue

Demonstrations of Photochemical Reactions Using Methylene Blue and Ascorbic Acid

Takahiro Suzuki, Kanon Ie, 隆良 木村, Yuika Shimizu et autres

Abstract Photochemical processes are important in nature and technology but can be difficult for students to conceptualize and visualize. In this study, a visible-light-responsive photochromic system comprising methylene blue (MB+) and ascorbic acid (AsA) is used for classroom demonstrations of photochemical reactions. …

jp (code pays fourni par la source)

Construction of a Chasmanine Skeleton Enabled by Hg(OAc)2-Promoted Vinylogous Mannich Reaction

Hibiki Asai, Shu Nakamura, Koichi Hagiwara, Masayuki Inoue

Chasmanine and puberuline C share a hexacyclic ABCDEF-ring but differ in the fusion pattern of their 5- and 6-membered F-rings. Here, we present a novel strategy for constructing the chasmanine skeleton, starting from a key intermediate employed in our total synthesis of …

jp (code pays fourni par la source)

Auxiliary medial small locking plate fixation enhances bone healing and minimizes delayed union in inverted V‐shaped high tibial osteotomy: A comparative study of 154 knees

Takuma Kaibara, Kazunori Yasuda, Eiji Kondo, Koji Yabuuchi et autres

Abstract Purpose To determine whether auxiliary fixation with a T‐shaped small locking plate (SLP) placed on the medial tibial cortex can enhance bone healing and reduce delayed union compared with the conventional inverted V‐shaped high tibial osteotomy (iVHTO) fixed with a locking …

jp, us (code pays fourni par la source)

Liposomal nanoprobes actuated by engineered water channels for sensitive detection of molecular targets by MRI

Sayani Das, Jacob Cyert Simon, Miranda Dawson, Vinay K. Sharma et autres

us, jp (code pays fourni par la source)

Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin

Wataru Shigematsu, Yo Matsumoto, Koichi Hagiwara, Masayuki Inoue

16β-Hydroxylpseudobufarenogin (1), isolated from the venom of Bufo bufo gargarizans, has potent anticancer activity. The U-shaped steroidal structure of 1 possesses a cis-fused AB-ring system, a densely oxidized cis-fused CD-ring system, and a β-oriented 2-pyrone at C17. Herein, we present a new …

jp (code pays fourni par la source)

Convergent Total Synthesis of 16β‐Hydroxylpseudobufarenogin

Wataru Shigematsu, Yo Matsumoto, Koichi Hagiwara, Masayuki Inoue

ABSTRACT 16β‐Hydroxylpseudobufarenogin ( 1 ), isolated from the venom of Bufo bufo gargarizans , has potent anticancer activity. The U‐shaped steroidal structure of 1 possesses a cis ‐fused AB‐ring system, a densely oxidized cis ‐fused CD‐ring system, and a β‐oriented 2‐pyrone at …

jp (code pays fourni par la source)

Convergent Synthesis of Methyl Peracetyl Hikosaminide Enabled by Intermolecular Radical Addition to Aldehyde

Haruka Fujino, Masayuki Inoue

Abstract Methyl peracetyl hikosaminide, a degradation product of the anthelmintic hikizimycin, comprises a linear carbon chain bearing 10 oxygen-substituted and 1 nitrogen-substituted functional groups. In 2017, we constructed this synthetically challenging structure through a novel radical–radical cross-coupling of two hexose-derived α-alkoxyacyl tellurides. …

jp (code pays fourni par la source)

Crystallographic snapshots of Trypanosoma cruzi aspartate transcarbamoylase including catalytic intermediates suggest an ordered Bi–Bi reaction mechanism

Kazuaki Matoba, Takeshi Nara, Takashi Aoki, Teruki Honma et autres

) from carbamoyl phosphate (CP) and aspartate (Asp). The ATCase from Trypanosoma cruzi (TcATCase) is a non-allosteric homotrimeric enzyme with all chains being catalytic and weakly inhibited by the general ATCase inhibitor, N-phosphonoacetyl-L-aspartate (PALA). While TcATCases is a compelling drug target, the …

jp, Nigéria (code pays fourni par la source)

Evaluation of Short-Term Clinical Results Following Isolated MPFL Reconstruction with Superficial Quadriceps or Hamstring Tendon in Patellar Dislocation: MPFL Reconstruction Using Quadriceps Versus Semitendinosus Autograft

Yuki Suzuki, Yoshimitsu Aoki, Chiharu Inoue, Hisashi Matsumoto et autres

Objectives: While hamstring autografts are widely used in medial patellofemoral ligament reconstruction (MPFLR), concerns have arisen regarding complications associated with the patella bone tunnel and fixation hardware, such as endobutton. As an alternative, the superficial quadriceps tendon (SQ) has also been used …

jp (code pays fourni par la source)

Medial closing wedge distal femoral varus osteotomy alters the stress distribution pattern of the patellofemoral joint: An evaluation using computed tomography osteoabsorptiometry

Masanari Hamasaki, Eiji Kondo, Koji Iwasaki, Yuki Suzuki et autres

Abstract Purpose This study aimed to (1) assess changes in subchondral bone density distribution across patellofemoral (PF) joint before and after medial closing wedge‐distal femoral varus osteotomy (MCW‐DFVO) and (2) determine correlation between PF alignment and changes in bone density distribution. Methods …

jp, us (code pays fourni par la source)

Total Synthesis and Functional Analysis of Loihichelin C: Structural Basis for Mn(III) Stabilization and Mn(II) Oxidation

Mizuki Sawada, Hiromu Kakizawa, Aoi Takeuchi, Hiroaki Itoh et autres

High Resolution Image Download MS PowerPoint Slide Loihichelin C ( 1a ) is a peptidic siderophore isolated from cultures of the bacterium Halomonas LOB-5 collected from deep-sea vent environments. Compound 1a is believed to promote microbial growth by coordinating to an Fe(III) …

jp (code pays fourni par la source)

Photoaffinity Labeling Strategy Reveals Tetraspanin CD9 as a Transient Target of Anticancer Yaku’amide B

Junhao Fu, Koichi Kamiya, Kai Kitamura, Ryo Kawahara et autres

Innovative chemical strategies are needed to understand the molecular targets of natural products, especially when they engage with multiple targets via transient interactions. Yaku’amide B ( 1 ), an anticancer natural product, inhibits mitochondrial F o F 1 -ATP synthase with nanomolar …

jp, sg (code pays fourni par la source)