Accès ouvert
2026
article
OpenAlex
Zoe Gotthold, Adam Epstein-Shuman, Godfrey Kigozi, Susanna L. Lamers et autres
We analyzed perinatal transmission in a pre-antiretroviral therapy Ugandan cohort by maternal human immunodeficiency virus type 1 subtype and infant sex in 131 mother-child pairs. Among all children, if the mother was infected with subtype A there was a nearly 3-fold increased …
us, Ouganda, Afrique du Sud
(code pays fourni par la source)
Accès ouvert
2026
article
OpenAlex
Edward Nelson Kankaka, Stephen Tomusange, Taddeo Kityamuweesi, Gabriel Quiros et autres
BACKGROUND: Estimating HIV viremic time helps better understand reservoir dynamics and inform cure trials. Traditional approaches rely on serological assays or CD4 counts, which can lack precision. Sequence-based estimates using pretreatment RNA diversity help address this, but are limited by immediate ART …
Ouganda, us, ca, Afrique du Sud
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Christophe Guy Éric Vanpouille, A. F. Wells, Victor DeGruttola, Miranda L. Lynch et autres
Background: Antiretroviral therapy (ART) suppresses HIV replication and partially restores immune function, but immunologic abnormalities often persist. Methods: We performed longitudinal multiparametric flow cytometry on peripheral blood mononuclear cells from 79 people with HIV-1 (51 women, 28 men) who were virologically suppressed …
us
(code pays fourni par la source)
2025
article
OpenAlex
Sarah LaMere, Ashley F. George, Nadia R. Roan, Nancie M. Archin et autres
PURPOSE OF REVIEW: As more women with HIV survive into older age, the menopausal transition has emerged as a critical yet underexplored determinant in HIV pathogenesis. Declining exposure to estrogens during menopause alters innate and adaptive immunity, driving inflammation, comorbidities, and viral …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Vivek Hariharan, Jennifer A. White, Filippo Dragoni, Emily J. Fray et autres
Abstract During replication of some RNA viruses, defective particles can spontaneously arise and interfere with wild-type (WT) virus replication. However, these defective interfering particles (DIPs) have not been reported in people with HIV-1 (PWH). Here we find DIPs in PWH who have …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Eileen P. Scully, Rosemary Morgan, Sabra L. Klein
Sex and gender have impacts on the responses to vaccination. Incorporating consideration of differences by sex and gender may facilitate more accurate communication about vaccines, the development of tailored approaches, and may enhance public trust.
us
(code pays fourni par la source)
2025
article
OpenAlex
Leon L. Hsieh, Elizabeth A. Thompson, Nirvani Jairam, Katerina Roznik et autres
Severe COVID-19 presents with a distinct immunological profile, characterized by elevated neutrophil and reduced lymphocyte counts, seen commonly in fungal and bacterial infections. This study demonstrates that patients hospitalized with COVID-19 show evidence of neutrophil degranulation and have increased expression of neutrophil …
us
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Accès ouvert
2025
article
OpenAlex
Sonya Krishnan, Eileen P. Scully
Sonya Krishnan, Eileen P Scully; Untangling the Sources of HIV-related Cardiovascular Risk, Clinical Infectious Diseases, , ciaf211, https://doi.org/10.109
us
(code pays fourni par la source)
Accès ouvert
2025
preprint
OpenAlex
Vivek Hariharan, Jennifer A. White, Filippo Dragoni, Emily J. Fray et autres
Abstract During replication of some RNA viruses, defective particles can spontaneously arise and interfere with wild-type (WT) virus replication. Recently, engineered versions of these defective interfering particles (DIPs) have been proposed as an HIV-1 therapeutic. However, DIPs have yet to be reported …
us
(code pays fourni par la source)
Accès ouvert
2025
article
OpenAlex
Lelia H. Chaisson, Fred C. Semitala, Sandra Mwebe, Eileen P. Scully et autres
BACKGROUND: Systematic tuberculosis (TB) screening is recommended for all people with HIV (PWH) because of its potential to improve TB outcomes through earlier diagnosis and treatment initiation. As such, systematic screening may be particularly important for men, who experience excess TB prevalence …
us, Ouganda
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Accès ouvert
2024
article
OpenAlex
Lelia H. Chaisson, Betina Durovni, Nasir Umar, Silvia Cohn et autres
OBJECTIVES: Worldwide, adult men experience an excess burden of tuberculosis (TB) disease compared with women, but few studies have examined sex differences in TB among people with HIV. In this study, we aimed to investigate sex differences in TB infection and disease …
us, cn, br
(code pays fourni par la source)
Accès ouvert
2024
article
OpenAlex
Christophe Vanpouille, Alan Wells, Victor DeGruttola, Miranda L. Lynch et autres
OBJECTIVE: Although antiretroviral therapy (ART) suppresses viral replication and reduces inflammation, it does not lead to the normalization of cytokines. The long-term effects of ART beyond viral suppression have not been studied and are mostly limited to cross-sectional research. DESIGN: The impact …
us
(code pays fourni par la source)