Antoine-Guy Lopez

La sérotonine, un nouvel outil pour le diagnostic de latéralisation des adénomes producteurs d'aldostérone (APA) ?

Céline Duparc, François Fraissinet, Stephanie Baron, Margot D’Agostino et autres

International audience

Biochemical diagnosis of pheochromocytoma and paraganglioma: analytical challenges and perspectives for optimization

François Fraissinet, Théophile Charpentier, Hélène Girot, Valéry Brunel et autres

Pheochromocytomas and paragangliomas (PPGL) are rare but potentially life-threatening neuroendocrine tumors whose diagnosis relies primarily on the biochemical detection of excessive catecholamine production or metabolism. Plasma free metanephrines and urinary fractionated metanephrines remain the cornerstone biomarkers recommended for initial screening. However, their …

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Glycemic control in critical care units: Moving towards individualized targets

G. Prevost, Emmanuel Besnier, Antoine-Guy Lopez

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Regulation of Aldosterone Secretion by Substance P and the Neurokinin Type 1 Receptor in Aldosterone‐Producing Adenomas

Antoine-Guy Lopez, Céline Duparc, Sylvie Renouf, Margot D’Agostino et autres

Background Aldosterone‐producing adenoma (APA) is a major cause of primary aldosteronism, the most frequent form of secondary hypertension. Although somatic mutations in ion channels within APA have been shown to activate Ca 2+ signaling and drive aldosterone production, the pathophysiology of primary …

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Caractéristiques des phéochromocytomes et paragangliomes révélés par une grossesse : étude multicentrique rétrospective

F. Chauvin, Estelle Louiset, Stéphanie Espiard, Lucas Bouys et autres

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Regulation of Aldosterone Secretion by Substance P and the NK1 Receptor in Aldosterone-Producing Adenomas

Antoine-Guy Lopez, Céline Duparc, Sylvie Renouf, Margot D’Agostino et autres

ABSTRACT Aldosterone-producing adenoma (APA) is a major cause of primary aldosteronism (PA), the most frequent form of secondary hypertension. Although somatic mutations in ion channels within APA have been shown to activate Ca 2+ signaling and drive aldosterone production, the pathophysiology of …

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Neurocrine regulation of aldosterone secretion: The role of substance P and NK1 receptor in aldosterone-producing adenomas

Antoine-Guy Lopez, Céline Duparc, Sylvie Renouf, Margot D’Agostino et autres

International audience

Rοle de la paracrinie dans la physiοpathοlοgie des hyperaldοsterοnismes primaires

Antoine-Guy Lopez

Introduction : L’hyperaldostéronisme primaire (HAP) est une cause fréquente d’hypertension artérielle secondaire. Les mécanismes impliqués dans la physiopathologie des adénomes producteurs d’aldostérone (APA) restent partiellement élucidés. La présence d’une innervation à substance P (SP) et de récepteurs NK1 dans la zone glomérulée …

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Young Athlete With Hypertension and Hypokalemia

Antoine-Guy Lopez, Dominique Guerrot

We describe a 17-year-old woman diagnosed with severe hypertension during routine follow-up after the prescription of a combined oral contraceptive pill. Initially, due to her age, the estradiol-containing contraception, and high-level sport practice, physicians suspected drug-induced hypertension. Blood tests showed hypokalemia, and …

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Serum levels of the incretin‐like peptide 26RFa are diminished in women living with obesity and diabetes and restored after sleeve gastrectomy: Results from the prospective pilot RFa ‐Ba‐S study

Hind Khiar, Émilie Lévêque, Antoine-Guy Lopez, Lucile Moreau‐Grangé et autres

AIM: To investigate the evolution of the incretin-like peptide 26RFa in a prospective cohort of women living with obesity with or without type 2 diabetes (T2D) before and after sleeve gastrectomy (SG). METHODS: In this study, a total of 61 women were …

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Aberrant hormone receptors regulate a wide spectrum of endocrine tumors

André Lacroix, Isabelle Bourdeau, Fanny Chasseloup, Peter Kamenický et autres

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Author response for "Serum levels of the incretin‐like peptide 26RFa are diminished in women living with obesity and diabetes and restored after sleeve gastrectomy: Results from the prospective pilot RFa ‐Ba‐S study"

Hind Khiar, Émilie Lévêque, Antoine-Guy Lopez, Lucile Moreau‐Grangé et autres