Emmanuel Besnier

Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence

Eva Correia, Thomas Maudhuizon, Antoine Hérault, Soumeya Bekri et autres

BACKGROUND: Hypertonic sodium lactate (HSL) has demonstrated beneficial effects in experimental sepsis, improving hemodynamics, modulating inflammation, and supporting cellular metabolism. Nevertheless, prior studies have not specifically addressed microcirculation, despite its critical impairment during sepsis and the absence of targeted therapies. We evaluated …

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Additional file 1 of Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence

Eva Correia, Thomas Maudhuizon, Antoine Hérault, Soumeya Bekri et autres

Supplementary Material 1

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Additional file 1 of Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence

Eva Correia, Thomas Maudhuizon, Antoine Hérault, Soumeya Bekri et autres

Supplementary Material 1

fr (code pays fourni par la source)

Additional file 3 of Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence

Eva Correia, Thomas Maudhuizon, Antoine Hérault, Soumeya Bekri et autres

Supplementary Material 3

fr (code pays fourni par la source)

Additional file 2 of Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence

Eva Correia, Thomas Maudhuizon, Antoine Hérault, Soumeya Bekri et autres

Supplementary Material 2

fr (code pays fourni par la source)

Additional file 2 of Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence

Eva Correia, Thomas Maudhuizon, Antoine Hérault, Soumeya Bekri et autres

Supplementary Material 2

fr (code pays fourni par la source)

Additional file 3 of Hypertonic sodium lactate improves microcirculation, modulates inflammation, and preserves vascular reactivity in a rat model of sepsis: in vivo and ex vivo evidence

Eva Correia, Thomas Maudhuizon, Antoine Hérault, Soumeya Bekri et autres

Supplementary Material 3

fr (code pays fourni par la source)

Arterial cannulation site and ventilation strategy modulate cerebral injury in a rat cardiopulmonary bypass model of Harlequin syndrome

Chadi Aludaat, Gabriel Saiydoun, Saadé Saadé, Jean‐Marc Baste et autres

BACKGROUND: Differential hypoxemia, or Harlequin syndrome, is a critical concern during veno-arterial extracorporeal membrane oxygenation (VA-ECMO), especially when femoral artery cannulation delivers retrograde flow. This phenomenon may impair cerebral oxygenation and promote brain injury. We investigated whether the arterial cannulation site and …

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In situ exploration of endothelial function in vasoplegic syndrome after cardiac surgery with cardiopulmonary bypass: protocol for a single-centre prospective cohort study – the Vasoshock study

Nicolas Ferry, Domitille Renard, André Gillibert, Thomas Clavier et autres

INTRODUCTION: Vasoplegic syndrome (VS) is a severe complication after cardiac surgery with cardiopulmonary bypass (CPB), characterised by vasodilation, hypotension and vasopressor dependence. Endothelial dysfunction, dysregulated nitric oxide signalling, inflammation and glycocalyx injury may contribute. Combining flow-mediated dilation (FMD), sublingual side-stream dark-field (SDF) …

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Preoperative Glycocalyx Status and Postoperative Organ Failure After Cardiac Surgery in the GLYPOCS Observational Cohort Study

Camille Molkhou, Zoé Demailly, Chanez Ait-Ali, Geoffrey Kouadri et autres

OBJECTIVES: Cardiac surgery with cardiopulmonary bypass induces systemic inflammation and glycocalyx degradation, both associated with postoperative complications. Cardiac surgery patients, who have multiple conditions affecting systemic microvascularization, may present with pre-existing alterations before surgery, and it is not known whether this increases …

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Comparison of aprotinin and tranexamic acid in the prevention of perioperative bleeding in non-elective cardiac procedures involving the ascending aorta

Loïc Kouame, Pierre Schmidely, Chadi Aludaat, Jean‐Marc Baste et autres

Background: Cardiac surgery involving the ascending aorta carries a significant risk of bleeding, needing the use of antifibrinolytic agents. However, there is still controversy regarding the optimal choice between aprotinin and tranexamic acid. Our objective was to compare the efficacy and safety …

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Fiche déchocage comité réanimation : déchoquer : une intoxication aux cardiotropes

Emmanuel Besnier, Mathieu Willig, Vincent Legros, Enora Atchade et autres