Sadhana Sharma

Clinical significance of B7-H4 expression in ovarian cancer: a meta-analysis of proportions and time-to-event survival outcomes

Seshadri Reddy Varikasuvu, Sadhana Sharma, Prateek Banerjee, Subodh Kumar et autres

B7-H4 is an immune-regulatory molecule increasingly recognized for its role in tumor progression and immune evasion in epithelial ovarian cancer. To clarify its clinical relevance, we conducted a systematic review and meta-analysis evaluating the prevalence of B7-H4 expression and its association with …

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Twacha, Vata and Mann: An Ayurvedic Approach to Psychodermatology

Prakarti Panwar, Sadhana Sharma, Mahendra K. Sharma, Rakesh Kumar Sharma

Introduction: In Ayurveda, Twak Vikar (Skin Disease) encompasses all pathological conditions affecting the skin physiology and anatomy, reflecting the body's and mind's state. The skin is influenced by psychological factors impacting quality of life. Aacharya Charak emphasizes the connection between Twacha (skin) …

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PLASTINATION: AN OVERVIEW OF THE REVOLUTIONARY TECHNIQUE IN PRESERVING BIOLOGICAL SPECIMENS FOR EDUCATION AND RESEARCH

Sadhana Sharma, Akhila Rajan, Shyoram Sharma, Rakesh Kumar Sharma

Plastination is a novel technique for biological specimen preservation. Plastination substitutes curable polymers for water and lipids in tissues, making specimens long-lasting, non-toxic, and odorless in contrast to conventional preservation methods, which frequently pose health risks and need upkeep. Fixation, dehydration, forced …

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Understanding Kshipra Marma – A Conceptual Exploration from Modern and Sushruta’s Perspectives

Sadhana Sharma, Kalpesh Malviya, Akhila Rajan, Rakesh Kumar Sahrma

Acharya Sushruta , the pioneer of Ayurvedic surgery, identified 107 critical anatomical areas known as Marmas. Kṣhipra Marma is a very sensitive place in the limbs that can lead to discomfort, deformity, and even death. Structurally it is classified as a Snayu …

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Surgical Removal of a Long-standing Impacted Tooth in Upper Alveolus Following Blast Injury: A Case Report

Arun Adhikari, Sadhana Sharma, Luna Mathema, Bijay Khatri

Injuries sustained from foreign bodies and burns after oil drum explosions are addressed immediately. This case reports a rare long-standing retained tooth after such an explosion. A 65-year-old male with a history of a victim of explosion injury to the face dating …

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Peer Review Report For: SARS-CoV-2 memory response in non-hospitalised cases: immunology in the context of a population-based cohort study [version 1; peer review: 1 approved, 1 approved with reservations]

Sadhana Sharma

Association of circulatory chemerin levels with the severity of pre-eclampsia: A systematic review and bootstrapped meta-analysis

Seshadri Reddy Varikasuvu, Mridul Madhuri, Asgar Ali, K Gowtham et autres

Introduction This study presents a systematic review and meta-analysis to investigate the association between circulating chemerin levels and the severity of preeclampsia (PE). Material and Methods A thorough search was conducted across multiple databases, including PubMed/MEDLINE, SCOPUS, and the Cochrane Library, up …

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Microbiome- and Host Inflammasome-Targeting Inhibitor Nanoligomers Are Therapeutic in the Murine Colitis Model

Sadhana Sharma, Vincenzo S. Gilberto, Cassandra L. Levens, Anushree Chatterjee et autres

High Resolution Image Download MS PowerPoint Slide Autoimmune and autoinflammatory diseases account for more than 80 chronic conditions affecting more than 24 million people in the US. Among these autoinflammatory diseases, noninfectious chronic inflammation of the gastrointestinal (GI) tract causes inflammatory bowel …

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Inflammasome-Inhibiting Nanoligomers Are Neuroprotective against Space-Induced Pathology in Healthy and Diseased Three-Dimensional Human Motor and Prefrontal Cortex Brain Organoids

Sadhana Sharma, Vincenzo S. Gilberto, Jon Rask, Anushree Chatterjee et autres

The microgravity and space environment has been linked to deficits in neuromuscular and cognitive capabilities, hypothesized to occur due to accelerated aging and neurodegeneration in space. While the specific mechanisms are still being investigated, spaceflight-associated neuropathology is an important health risk to …

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Nanoligomers targeting NF-κB and NLRP3 reduce neuroinflammation and improve cognitive function with aging and tauopathy

Devin Wahl, Sydney Risen, Shelby C. Osburn, Tobias Emge et autres

Neuroinflammation contributes to impaired cognitive function in brain aging and neurodegenerative disorders like Alzheimer's disease, which is characterized by the aggregation of pathological tau. One major driver of both age- and tau-associated neuroinflammation is the NF-κB and NLRP3 signaling axis. However, current …

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Exploring Marma Points Activation during Vajrasana Practice

Akhila Rajan, Sadhana Sharma, Shyoram Sharma, Rakesh Kumar Sharma

Abstract: Introduction: Yoga is an ancient Indian discipline that strives to combine an individual's physical, mental, and spiritual components. Vajrasana, also known as Thunderbolt Pose, is a foundational Yoga pose noted for its stability and advantages to meditation and physical wellness. This …

Targeted-Neuroinflammation Mitigation Using Inflammasome-Inhibiting Nanoligomers is Therapeutic in an Experimental Autoimmune Encephalomyelitis Mouse Model

Sadhana Sharma, Sydney Risen, Vincenzo S. Gilberto, Sean W. Boland et autres

Multiple sclerosis (MS) is a debilitating autoimmune disease that impacts millions of patients worldwide, disproportionately impacting women (4:1), and often presenting at highly productive stages of life. This disease affects the spinal cord and brain and is characterized by severe neuroinflammation, demyelination, …

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