Mohamed Taha Moutaoufik

Revisiting viral reprogramming: Measles virus as a robust platform for high-quality iPSC generation

Mohamed Taha Moutaoufik, Mohamed Chahine

Induced pluripotent stem cells (iPSCs) have become a powerful tool for modeling human disease in vitro, particularly for investigating patient-specific genetic disorders. By reprogramming somatic cells into pluripotent cells and differentiating them into relevant lineages, such as cardiomyocytes, neurons, or skeletal muscle …

Maroc, ca (code pays fourni par la source)

Global mitochondrial connectivity map reveals the landscape of yeast functional assemblies and conserved protein communities

Matthew Jessulat, Sadhna Phanse, Hiroyuki Aoki, Kirsten Broderick et autres

Mitochondria are essential organelles whose functions depend on coordinated multiprotein complexes, yet their composition and organization remain incomplete. Here, we present a large-scale map of mitochondrial protein complexes by integrating affinity purification of 740 endogenously GFP-tagged mitochondrial proteins with biochemical co-fractionation of …

ca, gb, il, us, Maroc, de, pr (code pays fourni par la source)

Editorial: Molecular mechanisms and precision medicine in rare diseases

Héctor Rodríguez Cetina Biefer, Abdallah Elkhal, Mohamed Taha Moutaoufik

The Research Topic "Molecular Mechanisms and Precision Medicine in Rare Diseases" comprises six contributions that are relevant and complementary in showing the utility of molecular research for the diagnosis and understanding of diseases, as well as the application of this knowledge for …

ch, us, Maroc (code pays fourni par la source)

CHCHD2 mutant mice link mitochondrial deficits to PD pathophysiology

Szu-Chi Liao, Kohei Kano, Sadhna Phanse, Mai K. Nguyen et autres

Mitochondrial dysfunction is a hallmark of Parkinson’s disease (PD), but the mechanisms by which it drives autosomal dominant and idiopathic forms of PD remain unclear. To investigate this, we generated and performed a comprehensive phenotypic analysis of a knock-in mouse model carrying …

us, ca, au, Maroc (code pays fourni par la source)

Non-Competitive AMPA Receptor Antagonist Perampanel Inhibits Ischemia-Induced Neurodegeneration and Behavioral Deficits in Focal Cortical Pial Vessel Disruption Stroke Model

Michael G. Zaki, Mohamed Taha Moutaoufik, Mahboubeh Pordeli, Mohan Babu et autres

Glutamate receptors represent a potential target for neuroprotection in neurodegenerative neurological conditions. Perampanel, a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) antagonist, is clinically approved for the management of epilepsy. Perampanel's neuroprotective effects have been reported in global and focal cerebral ischemia models, but …

ca (code pays fourni par la source)

Non-Competitive AMPA Receptor Antagonist Perampanel Inhibits Ischemia-Induced Neurodegeneration and Behavioral Deficits in Focal Cortical Pial Vessel Disruption Stroke Model

Michael G. Zaki, Mohamed Taha Moutaoufik, Mahboubeh Pordeli, Mohan Babu et autres

Glutamate receptors represent a potential target for neuroprotection in neurodegener-ative neurological conditions. Perampanel, a non-competitive α-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor (AMPAR) antagonist, is clinically approved for the management of epilepsy. Perampanel’s neuroprotective ef-fects have been reported in global and focal cerebral ischemia models, but …

ca (code pays fourni par la source)

The role of CHCHD2 in mitochondrial dysfunction in parkinson’s disease pathology: a multi-omics approach

Fatima Ezzahraa Elhaou, Rami Ayadi, Rachid El Fatimy, Mohamed Taha Moutaoufik

Maroc (code pays fourni par la source)

Mitochondrial interactomes and neurodegenerative disease mechanisms

Mohamed Taha Moutaoufik

Maroc (code pays fourni par la source)

In silico modeling of LRRK2 G2019S protein-protein interactions in Parkinson’s disease: A machine learning approach

Hiba Midouane, Qingzhou Zhang, Rami Ayadi, Ines ELBini et autres

Maroc, Tunisie (code pays fourni par la source)

Elucidating the complex protein-protein interactions in Huntington’s disease

Aya El Haqaoui, Mohamed Taha Moutaoufik, Abdellatif Abbaoui

Maroc (code pays fourni par la source)

Human protein interaction networks of ancestral and variant SARS-CoV-2 in organ-specific cells and bodily fluids

Kirsten Broderick, Mohamed Taha Moutaoufik, Tatiana D. Saccon, Ramy Malty et autres

Understanding SARS-CoV-2 human protein-protein interactions (PPIs) and the host response to infection is essential for developing effective COVID-19 antivirals. However, how the ancestral virus and its variants remodel virus-host protein assemblies in various organ-specific cells and bodily fluids remains unclear. Here, we …

ca, Maroc, us (code pays fourni par la source)

Ligand interaction landscape of transcription factors and essential enzymes in E. coli

Hui Peng, Sergei Kotelnikov, Megan Egbert, Shany Ofaim et autres

Knowledge of protein-metabolite interactions can enhance mechanistic understanding and chemical probing of biochemical processes, but the discovery of endogenous ligands remains challenging. Here, we combined rapid affinity purification with precision mass spectrometry and high-resolution molecular docking to precisely map the physical associations …

ca, us, Maroc (code pays fourni par la source)