Weiwei Jiang

Comparative efficacy and safety of surgical interventions for communicating hydrocephalus: a systematic review and network meta-analysis of randomized controlled trials

Zhihao Zhao, Yang Liu, Weiwei Jiang, Shuangyu Wang et autres

Objectives: Surgical intervention is the standard treatment for communicating hydrocephalus (CH), a condition involving cerebrospinal fluid (CSF) accumulation in the ventricles without a blockage. The optimal surgical approach for CH remains uncertain, with clinical decisions varying by patient characteristics and institutional practices. …

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Efficacy and safety of L-oxiracetam on cognitive function in patients with traumatic brain injury: a multicentre, randomised, double-blind, phase 3 clinical trial

Tao Liu, Zhihao Zhao, Weiwei Jiang, Minzhi Zhang et autres

To assess the efficacy and safety of L-oxiracetam, a novel nootropic agent, in improving cognition in patients with TBI, we performed a multicentre, double-blind, randomized controlled trial in China. Participants aged 18 to 75 years with TBI (Glasgow Coma Scale score of …

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Knockdown of NFS1 and Oxaliplatin Combination Induces Pyroptosis viathe Caspase-3/GSDME Pathway in Gastric Cancer Cells

Weiwei Jiang, Miao Zhang, Nan Hu, Chenxi Mao et autres

INTRODUCTION: This study aimed to elucidate the role of NFS1 in gastric cancer (GC) prognosis, pyroptosis, and oxaliplatin chemosensitivity, and to explore its interaction with the MAPK signaling pathway. METHODS: GC mRNA expression and clinical survival data were obtained from The Cancer …

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Low-intensity pulsed ultrasound elevates blood pressure for shock

Chenrui Wu, Yu Shun Tian, Tao Liu, Shuo An et autres

Fluid replacement is the primary treatment for life-threatening shock but is challenging in harsh environments. This study explores low-intensity pulsed ultrasound (LIPUS) as a resuscitation strategy. Cervical LIPUS stimulation effectively elevated blood pressure in shocked rats. It also improved cerebral and multiorgan …

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Genetic deletion of G protein-coupled receptor 56 aggravates traumatic brain injury through the microglial CCL3/4/5 upregulation targeted to CCR5

Zhuang Sha, Shiying Dong, Meng Nie, Tao Liu et autres

Traumatic brain injury (TBI) is a significant global health concern that often results in death or disability, and effective pharmacological treatments are lacking. G protein-coupled receptor 56 (GPR56), a potential drug target, is crucial for neuronal and glial cell function and therefore …

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Efficacy and safety of compound porcine cerebroside and ganglioside injection (CPCGI) versus piracetam on cognition and functional outcomes for adults with traumatic brain injury: A study protocol for randomized controlled trial

Tao Liu, Yunhu Yu, Liang Mi, Zhihao Zhao et autres

Background: Traumatic brain injury (TBI) is a common neurosurgical disease in emergency rooms with poor prognosis, imposing severe burdens on patients and their families. Evidence indicates that piracetam and compound porcine cerebroside and ganglioside injection (CPCGI) can improve cognitive levels in TBI …

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FTO is Associated with Patient Prognosis and Immune Infiltrates in Gastric Cancer and Regulates TGF-β Expression

Huan Sheng Lai, Nan Hu, Miao Zhang, Weiwei Jiang et autres

OBJECTIVE: This study aimed to examine the associations of FTO expression with prognosis, tumor microenvironment (TME), immune cell infiltration, immune checkpoint genes, and relevant signaling pathways in GC. Furthermore, the relationship between FTO and TGF-β was studied in GC. METHODS: The mRNA …

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Effect of L ‐oxiracetam and oxiracetam on memory and cognitive impairment in mild‐to‐moderate traumatic brain injury patients: Study protocol for a randomized controlled trial

Tao Liu, Mingqi Liu, Meng Nie, Zhihao Zhao et autres

Objectives: Patients with traumatic brain injury (TBI) often suffer memory and cognitive impairments, and oxiracetam-like drugs are considered to have a positive impact on these symptoms potentially. However, the efficacy and safety of l-oxiracetam and oxiracetam in TBI patients have not been …

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Cannabidiol Alleviates Neurological Deficits After Traumatic Brain Injury by Improving Intracranial Lymphatic Drainage

Shiying Dong, Hongwei Zhao, Meng Nie, Zhuang Sha et autres

Traumatic brain injury (TBI) persists as a substantial clinical dilemma, largely because of the absence of effective treatments. This challenge is exacerbated by the hindered clearance of intracranial metabolic byproducts and the continual accrual of deleterious proteins. The glymphatic system (GS) and …

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CD4 + CD11b + T cells infiltrate and aggravate the traumatic brain injury depending on brain‐to‐cervical lymph node signaling

Weiwei Jiang, Xuanhui Liu, Yupeng Chen, Mingqi Liu et autres

Abstract Aim We aim to identify the specific CD4+ T‐cell subtype influenced by brain‐to‐CLN signaling and explore their role during the acute phase of traumatic brain injury (TBI). Method Cervical lymphadenectomy or cervical afferent lymphatic ligation was performed before TBI. Cytokine array …

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Insulin modified Decellularized Adipose Tissue/Tremella Polysaccharide hydrogel loaded with ADSCs for skin wound healing

Jianyue Dong, Linghong Kong, Weiwei Jiang, Qi Wang et autres

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PLGA@IL-8 nanoparticles-loaded acellular dermal matrix as a delivery system for exogenous MSCs in diabetic wound healing

Yue Zhang, Weiwei Jiang, Linghong Kong, Jinping Fu et autres

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