Norbert Weiss

Temperature-dependent functional inversion of Cav3.2 channels during repetitive activity

Kacper Pawlak, Petr Daněk, Bohumila Jurkovičová-Tarabová, Norbert Weiss

Abstract Temperature strongly influences neuronal excitability and voltage-gated ion channel function. Ca v 3.2 T-type calcium channels are highly expressed in dorsal root ganglion and trigeminal ganglion neurons, where they contribute to nociceptive signaling, cold hypersensitivity, and neuropathic pain. However, how temperature …

cz, sk (code pays fourni par la source)

Pathophysiology of homocysteine: insights into ion channel dysfunction

Nikola Chmúrčiaková, Robin N. Stringer, Leoš Cmarko, Alzbeta Filipova et autres

Homocysteine is a non-proteinogenic amino acid formed during the metabolism of methionine to cysteine and plays a critical role in maintaining cellular homeostasis. Although multiple enzymatic pathways tightly regulate homocysteine levels, their dysfunction can lead to elevated circulating homocysteine, which is recognized …

cz, sk (code pays fourni par la source)

Electrophysiological classification of CACNA1G gene variants associated with neurodevelopmental and neurological disorders

Amaël Davakan, Leoš Cmarko, Bárbara Bruna Ribeiro Oliveira-Mendes, Claire Bernat et autres

This study highlights the complementarity of automated patch-clamp (APC) and manual patch-clamp (MPC) approaches to describe the electrophysiological properties of eighteen Cav3.1 calcium channel variants associated with various neurological conditions. Current density was measured efficiently for all variants in APC experiments, with …

fr, cz, us (code pays fourni par la source)

Diagnostic yield of standardized screening for deep venous thrombosis in patients with acute cerebral ischemia and cardiac right-to-left shunt

K. M. Michael, Lars P Pallesen, Jozef Kaiser, Timo Siepmann et autres

BACKGROUND: Paradoxical embolism is a potential pathophysiology in patients with acute ischemic stroke or transient ischemic attack (TIA) and patent foramen ovale (PFO) or atrial septal defect (ASD). We sought to determine the frequency of deep vein thrombosis (DVT) detection by standardized …

de (code pays fourni par la source)

Homocysteine enhances the excitability of cultured hippocampal neurons without altering the gene expression of voltage-gated ion channels

Alzbeta Filipova, Matúš Tomko, Katarína Ondáčová, Lucia Hoppanová et autres

Elevated plasma homocysteine (Hcy) levels lead to hyperhomocysteinemia, a condition associated with various neurological disorders affecting multiple brain regions, including the hippocampus. In this study, we investigated the effects of exposing cultured rat hippocampal neurons to Hcy concentrations corresponding to mild, moderate, …

sk, cz (code pays fourni par la source)

Functional characterization of a novel de novo CACNA1C pathogenic variant in a patient with neurodevelopmental disorder

Robin N. Stringer, Xuechen Tang, Bohumila Jurkovičová-Tarabová, Mary Murphy et autres

Abstract Mutations in CACNA1C, the gene encoding Cav1.2 voltage-gated calcium channels, are associated with a spectrum of disorders, including Timothy syndrome and other neurodevelopmental and cardiac conditions. In this study, we report a child with a de novo heterozygous missense variant (c.1973T …

cz, at, sk (code pays fourni par la source)

Electrophysiological characterization of sourced human iPSC-derived motor neurons

Bohumila Jurkovičová-Tarabová, Robin N. Stringer, Zuzana Tomaskova, Norbert Weiss

Induced pluripotent stem cell (iPSC)-derived motor neurons provide a powerful platform for studying motor neuron diseases. These cells enable human-specific modeling of disease mechanisms and high-throughput drug screening. While commercially available iPSC-derived motor neurons offer a convenient alternative to time-intensive differentiation protocols, …

sk, cz (code pays fourni par la source)

Electrophysiological classification of CACNA1G gene variants associated with neurodevelopmental and neurological disorders

Amaël Davakan, Leoš Cmarko, Claire Bernat, Najlae Boulali et autres

Abstract This study highlights the complementarity of automated patch-clamp (APC) and manual patch-clamp (MPC) approaches to describe the electrophysiological properties of eighteen Ca v 3.1 calcium channel variants associated with various neurological conditions. Current density was measured efficiently for all variants in …

fr, de, cz, us (code pays fourni par la source)

Neutrophil Extracellular Traps (NETs) as a Potential Target for Anti-Aging: Role of Therapeutic Apheresis

Natalia Jarzebska, Roman N. Rodionov, Karin Voit-Bak, Richard Straube et autres

Neutrophil extracellular traps (NETs) are large structures composed of chromatin, histones and granule-derived proteins released extracellularly by neutrophils. They are generally considered to be a part of the antimicrobial defense strategy, preventing the dissemination of pathogens. However, overproduction of NETs or their …

de, au, gb (code pays fourni par la source)

Fantastic Plastic?

M Vogler, Max Jonathan Stumpf, Norbert Weiss

de (code pays fourni par la source)

Pathophysiologie der Atherosklerose

Roman N. Rodionov, Natalia Jarzebska, Henning Morawietz, Claudia Göttsch et autres

de, ee (code pays fourni par la source)

Management kardiovaskulärer Risikofaktoren

Norbert Weiss, Gesine Dörr

de (code pays fourni par la source)