Martin Müller

Neue Hemmstoffe des RAAS für die Blutdrucksenkung

Martin Müller, Johannes Stegbauer

de (code pays fourni par la source)

AS04 drives superior cross-protective antibody response by increased NOTCH signaling of dendritic cells and proliferation of memory B cells

Valentino D’Onofrio, Alfredo Santana, Marthe Pauwels, Gwenn Waerlop et autres

Introduction: targets HPV types 16 and 18 using AS04 (Al(OH)3 + TLR4 agonist MPL) to enhance immune response. Cervarix elicits higher cross-protection against other high-risk HPV types, likely mediated by AS04. Methods: To investigate mechanisms of cross-neutralizing potential, six monozygotic twins (12 …

be, us, de (code pays fourni par la source)

Prognostic impact of clonal representation of myelodysplasia-related gene mutations in acute myeloid leukemia

Rabea Mecklenbrauck, Nora Borchert, Razif Gabdoulline, Carolin Funke et autres

According to the international consensus classification (ICC) nine mutations define acute myeloid leukemia (AML) with myelodysplasia-related gene (MRG) mutations: ASXL1, BCOR, EZH2, RUNX1, SF3B1, SRSF2, STAG2, U2AF1 and ZRSR2 [ 1 ]. Patients with MRG mutations have been shown to be older, …

de, gb (code pays fourni par la source)

Inhibitors of dihydroorotate dehydrogenase synergize with the broad antiviral activity of 4′-fluorouridine

Leon Schrell, Hannah L Fuchs, Antje Dickmanns, David Scheibner et autres

ABSTRACT RNA viruses present a constant threat to human health, often with limited options for vaccination or therapy. Notable examples include influenza viruses and coronaviruses, which have pandemic potential. Filo- and henipaviruses cause more limited outbreaks, but with high case fatality rates. …

us, de, at, hu (code pays fourni par la source)

Lack of detectable HPV18 antibodies in 14% of quadrivalent vaccinees in a longitudinal cohort study

Penelope Gray, Filipe Colaço Mariz, Carina Eklund, Tiina Eriksson et autres

Abstract Although HPV vaccines are highly efficacious, a notable proportion of quadrivalent vaccinees are HPV18 seronegative post-vaccination. We have investigated this findings’ validity by comparing vaccine-induced antibody responses using two different immunoassays. 6558 16–17-year-old females participated in the FUTURE II (NCT00092534) and …

se, de, fi (code pays fourni par la source)

A safe and potentiated multi-type HPV L2-E7 nanoparticle vaccine with combined prophylactic and therapeutic activity

Xueer Zhao, Yueru Zhang, Óscar Trejo-Cerro, Ecem Kaplan et autres

Persistent infection with high-risk human papillomavirus (HPV) is widely recognized as the primary cause of cervical and other malignant cancers. There are six licensed prophylactic vaccines available against HPV, but none of them shows any significant therapeutic effect on pre-existing infections or …

de, it (code pays fourni par la source)

Deciphering the NPM1c epigenetic network in acute myeloid leukemogenesis

Sofia Gama, V Wingenfeld, Martin Müller, H Issa et autres

Nucleophosmin 1 (NPM1) gene encodes for a multifunctional nucleolar protein that shuttles between the nucleus and cytoplasm. NPM1 mutations are the most common genetic lesion in AML, accounting for one-third of cases, resulting in a cytoplasmic mislocalization of the protein (NPM1c). Until …

Cellular Importin-α3 Expression Dynamics in the Lung Regulate Antiviral Response Pathways against Influenza A Virus Infection

Swantje Thiele, Stephanie Stanelle‐Bertram, Sebastian Beck, Nancy Mounogou Kouassi et autres

Inter-epitope spacer variation within polytopic L2-based human papillomavirus antigens affects immunogenicity

Yueru Zhang, Filipe Colaço Mariz, Peter Sehr, Gloria Spagnoli et autres

The human papillomavirus minor capsid protein L2 is being extensively explored in pre-clinical studies as an attractive vaccine antigen capable of inducing broad-spectrum prophylactic antibody responses. Recently, we have developed two HPV vaccine antigens - PANHPVAX and CUT-PANHPVAX- both based on heptameric …

de, it (code pays fourni par la source)

Impact of age at vaccination and cervical HPV infection status on binding and neutralizing antibody titers at 10 years after receiving single or higher doses of quadrivalent HPV vaccine

Neerja Bhatla, Richard Muwonge, Sylla G. Malvi, Smita Joshi et autres

Long-term follow-up of a cohort of unmarried girls who received one, two, or three doses of quadrivalent HPV vaccine, between 10 and 18 years of age, in an Indian multi-centric study allowed us to compare antibody responses between the younger and older …

in, fr, us, de (code pays fourni par la source)

Adeno‐Associated Virus Type 5 Infection via PDGFRα Is Associated With Interstitial Lung Disease in Systemic Sclerosis and Generates Composite Peptides and Epitopes Recognized by the Agonistic Immunoglobulins Present in Patients With Systemic Sclerosis

Gianluca Moroncini, Silvia Svegliati, Antonella Grieco, Massimiliano Cuccioloni et autres

OBJECTIVE: The etiopathogenesis of systemic sclerosis (SSc) is unknown. Platelet-derived growth factor receptors (PDGFRs) are overexpressed in patients with SSc. Because PDGFRα is targeted by the adeno-associated virus type 5 (AAV5), we investigated whether AAV5 forms a complex with PDGFRα exposing epitopes …

it, de, us (code pays fourni par la source)

Advances on two serological assays for human papillomavirus provide insights on the reactivity of antibodies against a cross-neutralization epitope of the minor capsid protein L2

Filipe Colaço Mariz, Kerstin Putzker, Peter Sehr, Martin Müller

Introduction: A second generation of prophylactic human papillomavirus (HPV) vaccines based on the minor capsid protein L2 has entered clinical trials as promising alternative to meet the gaps left out by the current vaccines concerning type-restricted protection, high costs and low penetrance …

de (code pays fourni par la source)