Penelope Grace Gray

Evidence for type replacement as a consequence of vaccination and implications for cervical screening

Penelope Grace Gray, Karolina Louvanto

The success of prophylactic human papillomavirus (HPV) vaccination in reducing disease burden came with an epidemiological concern: HPV type replacement, the potential compensatory increase of nonvaccine targeted HPV types following the elimination of HPV16 and 18. Postvaccination surveillance across several countries suggests …

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Nationwide audit of cervical cancer screening reveals unsatisfactory triage strategies and trends over time in incidence among cytology negative women

Cecilia Kärrberg, Penelope Grace Gray, Kristina Elfgren, Hanna Milerad et autres

Regular audits are essential for monitoring and evaluation of cervical screening. We audited the Swedish cervical screening program during the transition to HPV-based screening using a registry-based cohort design. In total, 5689 consecutive, confirmed cases of invasive cervical cancer between 2012 and …

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Evaluation of an HPV16-L1 antibody rapid test for oropharyngeal cancer diagnosis: diagnostic accuracy and challenges in real-world settings

Johannes M A Kusters, Nicole Brenner, Johannes A. Bogaards, Steffi Silling et autres

BACKGROUND: Diagnostic assays have been introduced to diagnose human papillomavirus (HPV)-driven oropharyngeal cancer (HPV-OPC), including those identifying HPV16-L1 antibodies. This study aims to evaluate the diagnostic accuracy of an HPV16-L1 antibody rapid test for HPV-OPC, and its performance in individuals likely to …

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Controlled trial of cervical cancer screening frequency among human‐papillomavirus‐vaccinated women

Mònica Ortega Llobet, Penelope Grace Gray, Iacopo Baussano, Miriam K. Elfström et autres

Cervical screening frequency has not been studied in vaccinees. As the major risk factor, oncogenic human papillomavirus (HPV) is declining due to vaccination. We report a trial to assess the effectiveness of cervical screening frequency among women HPV-vaccinated as early adolescents (NCT02149030). …

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Interval cervical cancers after self-sampling for human papillomavirus in the general population

Penelope Grace Gray, Joakim Dillner

Cervical screening using testing for human papillomavirus (HPV) is a globally recommended public health policy.1 Self-sampling for HPV testing is advised in the World Health Organization strategy for global elimination of cervical cancer as a cost-saving alternative that is more acceptable for …

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The challenges of immunobridging without established correlates of vaccine-induced protection

Penelope Grace Gray

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[HPV screening coverage and cancer].

Joakim Dillner, Penelope Grace Gray

The incidence of cervical cancer after a normal cytology test has been increasing, and now women with a normal cytology have a cancer risk almost as high as the general population. The incidence of cervical cancer after a negative HPV test is …

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Scientific approaches to defining HPV vaccine‐induced protective immunity

Matti Lehtinen, Pierre Van Damme, Simon A. Beddows, Lígia A. Pinto et autres

Seventeen years after the licensure of prophylactic human papillomavirus (HPV) L1 virus-like-particle vaccines, a defined antibody level that correlates with vaccine-induced protection against HPV infections and associated neoplasia is missing. In contrast, correlates of protection have been defined for many viral vaccines, …

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Population-Based Age-Period-Cohort Analysis of Declining Human Papillomavirus Prevalence

Penelope Grace Gray, Jiangrong Wang, Sara Nordqvist Kleppe, Miriam K. Elfström et autres

BACKGROUND: Most countries in the world have launched human papillomavirus (HPV) vaccination programs, and declining HPV prevalences are reported. We aimed to disentangle the influences of calendar time, birth cohort, and age by analyzing HPV prevalences in the population-based cervical screening program …

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Head-to-head comparison of two human papillomavirus vaccines for efficacy against cervical intraepithelial neoplasia grade 3 and adenocarcinoma in situ—population-based follow-up of two cluster-randomized trials

Matti Lehtinen, Penelope Grace Gray, Tapio Luostarinen, Tiina Eriksson et autres

Introduction: We report head-to-head comparison of the bivalent and quadrivalent HPV vaccine efficacies against immediate precursors of cervical cancer from 15 years' country-wide cancer registry follow-up of phase III trial cohorts and an age-aligned cohort of unvaccinated women. Methods: These individually and/or …

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Lack of detectable HPV18 antibodies in 14% of quadrivalent vaccinees in a longitudinal cohort study

Penelope Grace Gray, Filipe Colaço Mariz, Carina Eklund, Tiina Eriksson et autres

Abstract Although HPV vaccines are highly efficacious, a notable proportion of quadrivalent vaccinees are HPV18 seronegative post-vaccination. We have investigated this findings’ validity by comparing vaccine-induced antibody responses using two different immunoassays. 6558 16–17-year-old females participated in the FUTURE II (NCT00092534) and …

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Seroepidemiological assessment of the spread of SARS-CoV-2 among 25 and 28 year-old adult women in Finland between March 2020-June 2022

Penelope Grace Gray, Tiina Eriksson, Lovisa Skoglund, Camilla Lagheden et autres

INTRODUCTION: Serological surveys of the prevalence of SARS-CoV-2 are instrumental to understanding the course of the COVID-19 epidemic. We evaluate the seroprevalence of SARS-CoV-2 among young adult Finnish females residing in 25 communities all over Finland from 2020 until 2022. METHODS: Between …

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