Valentino D’Onofrio

LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

Valentino D’Onofrio, Marjolein Verstraete, Sharon Porrez, Bart Jacobs et autres

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Queer Science and Scientists Are Shaping the Future of Immunology

Audrey Kahn, Rosalie Kempkes, Valentino D’Onofrio, the yEFIS Equity & Diversity Working Group

The authors declare no conflicts of interest. Data sharing not applicable to this article, as no datasets were generated or analyzed during this study.

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LiteVax-adjuvanted influenza vaccine induces transient interferon-driven innate activation and accelerates early IgG3 responses in older adults

Valentino D’Onofrio, Marjolein Verstraete, Sharon Porrez, Bart Jacobs et autres

Vaccine immunogenicity declines with age due to immunosenescence, underscoring the need for improved adjuvants. LiteVax Adjuvant (LVA), a squalane-in-water emulsion containing carbohydrate fatty-acid monosulphate esters, has shown potential to enhance influenza vaccine responses, but its mechanisms in humans remain unclear. We performed …

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A unified network systems approach uncovers a core novel program underlying T follicular helper cell differentiation 2260705

Alisa A. Omelchenko, Syed A. Rahman, Vinay Viswanadham, Grace J. Yuen et autres

Abstract Introduction The complexity of T follicular helper (Tfh) cell populations and inconsistent findings across experimental systems have fueled ongoing debate regarding Tfh differentiation. Without a unified systems approach, it remains unclear whether these inconsistencies stem from technical artifacts or true biological …

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A unified network systems approach uncovers a core program underlying T follicular helper cell differentiation

Alisa A. Omelchenko, Syed A. Rahman, Alyson Wang, Tracy Tabib et autres

Characterizing multi-scale processes underlying immune-state progression is critical for defining their function. This becomes pertinent for functionally diverse and plastic immune cells, such as T follicular helper (Tfh) cells. Here, we adopt a multi-scale network-systems approach that incorporates both regulatory and protein-protein …

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Cytokine dynamics following initiation of gender-affirming hormone therapy in transgender subjects

Yaël Sertons, Sarah Collet, Jeroen Vervalcke, Justine Defreyne et autres

BACKGROUND: Sex is an important determinant for various immune system-related pathologies and sex steroids might possess immunomodulatory properties. OBJECTIVE: To study the effects of sex steroid exposure on the serum levels of immune-related biomarkers (irBMS), using a model of transgender individuals receiving …

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A first-in-human Phase 1/1b randomized trial evaluating the safety and immunogenicity of a respiratory syncytial virus (RSV) virus-like particle subunit vaccine (IVX-121) in healthy young and older adults

Ilse De Coster, Isabel Leroux‐Roels, Kanchanamala Withanage, Leen Suykens et autres

Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract disease in all age groups, with substantial burden in older adults. Here, we report the safety and immunogenicity of IVX-121, an investigational virus-like particle vaccine against RSV. This Phase 1/1b …

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Paced immune activation by AS04 drives superior cross-protective antibody response in Cervarix 2918

Valentino D’Onofrio, Anthony Willems, Ana Carolina Santana, Marthe Pauwels et autres

Abstract Description The Gardasil®-4 vaccine targets HPV type 6,11,16 and 18 and is formulated with AlHO9PS-3. Cervarix® targets HPV type 16 and 18 using AS04 (Al(OH)3 + TLR4 agonist MPL) to enhance immunogenicity and cross-protection against non-vaccine HPV types. To investigate mechanisms …

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A Novel Carbohydrate Fatty-Acid Monosulphate Ester, Squalane-in-Water Adjuvant Is Safe and Enhances Inactivated Influenza Vaccine Immunogenicity in Older Adults

Valentino D’Onofrio, Bart Jacobs, Azhar Alhatemi, Simon De Gussem et autres

Influenza vaccines are the primary strategy to prevent severe influenza disease; however, their efficacy is often suboptimal, particularly in older adults (OAs). LiteVax Adjuvant (LVA), a novel adjuvant containing carbohydrate fatty-acid monosulphate ester (CMS) as the active ingredient, has demonstrated a favourable …

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AS04 drives superior cross-protective antibody response by increased NOTCH signaling of dendritic cells and proliferation of memory B cells

Valentino D’Onofrio, Alfredo Santana, Marthe Pauwels, Gwenn Waerlop et autres

Introduction: targets HPV types 16 and 18 using AS04 (Al(OH)3 + TLR4 agonist MPL) to enhance immune response. Cervarix elicits higher cross-protection against other high-risk HPV types, likely mediated by AS04. Methods: To investigate mechanisms of cross-neutralizing potential, six monozygotic twins (12 …

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AS04 in a bivalent HPV vaccine drives superior cross-protective antibody response by increased NOTCH signaling of cDC1 leading to increased proliferation of adaptive immune cells

Valentino D’Onofrio, Ana Carolina Santana, Marthe Pauwels, Gwenn Waerlop et autres

Abstract Introduction Cervarix® and Gardasil® are two HPV vaccines with differing antigen and adjuvant compositions. Gardasil-4 contains HPV types 6, 11, 16 and 18 type-specific L1 viral like particles (VLPs) formulated with amorphous AlHO9PS-3 adjuvant, while Cervarix targets HPV types 16 and …

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Synthetic plasma pool cohort correction for affinity-based proteomics datasets allows multiple study comparison

Dries Heylen, Murih Pusparum, Jurgis Kuliesius, Jim Wilson et autres

Proteomics stands as the crucial link between genomics and human diseases. Quantitative proteomics provides detailed insights into protein levels, enabling differentiation between distinct phenotypes. OLINK, a biotechnology company from Uppsala, Sweden, offers a targeted, affinity-based protein measurement method called Target 96, which …

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