Sandra Laston

Genetic Variants and Molecular Components Associated with Metabolic Dysfunctional-Associated Steatotic Liver Disease and Depression: Shared Association of ADAMTS7 and THRAP3

Eron G. Manusov, Vincent P. Diego, Marcio A. A. Almeida, Jacob A. Galán et autres

Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) and depression frequently occur together. Identifying the genes that influence both MASLD and depression may facilitate the discovery of biological pathways associated with disease risk. Methods: We recruited 525 participants from Mexican American families living …

us (code pays fourni par la source)

Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children

Nancy F. Butte, Ruixue Hou, Sandra Laston, Anthony G. Comuzzie et autres

us (code pays fourni par la source)

Genotype-by-Environment Interactions in Nonalcoholic Fatty Liver Disease and Chronic Illness among Mexican Americans: The Role of Acculturation Stress

Eron G. Manusov, Vincent P. Diego, Marcio Almeida, David Ortiz et autres

This study examines the complex interplay of genetic and environmental interactions that shape chronic illness risk. Evidence is mounting for the role of genetic expression and the immune response in the pathogenesis of chronic disease. In the Rio Grande Valley of south …

us (code pays fourni par la source)

Statistical Genetic Approaches to Investigate Genotype-by-Environment Interaction: Review and Novel Extension of Models

Vincent P. Diego, Eron G. Manusov, Marcio Almeida, Sandra Laston et autres

Statistical genetic models of genotype-by-environment (G×E) interaction can be divided into two general classes, one on G×E interaction in response to dichotomous environments (e.g., sex, disease-affection status, or presence/absence of an exposure) and the other in response to continuous environments (e.g., physical …

us (code pays fourni par la source)

Genetic variants affecting bone mineral density and bone mineral content at multiple skeletal sites in Hispanic children

Rong Hou, Diana L. Cousminer, Shelley A. Cole, A.G. Comuzzie et autres

Genetic variants and physical activity interact to affect bone density in Hispanic children

Nitesh R. Mehta, Roman J. Shypailo, K.E. North, Margaret L. Gourlay et autres

Background: Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study. Methods: Physical …

Fine mapping and identification of serum urate loci in American Indians: The Strong Heart Family Study

V. Saroja Voruganti, L.G. Best, C. Bizon, Sandra Laston et autres

While studies have reported genetic loci affecting serum urate (SU) concentrations, few studies have been conducted in minority populations. Our objective for this study was to identify genetic loci regulating SU in a multigenerational family-based cohort of American Indians, the Strong Heart …

Gene-by-Environment Interaction in Non-Alcoholic Fatty Liver Disease and Depression: The Role of Hepatic Transaminases

Eron G. Manusov, Vincent P. Diego, E. Abrego, Kathryn Herklotz et autres

Non-alcoholic fatty liver disease (NAFLD) encompasses a range of liver conditions, from benign fatty accumulation to severe fibrosis. The global prevalence of NAFLD has risen to 25-30%, with variations across ethnic groups. NAFLD may advance to hepatocellular carcinoma, increases cardiovascular risk, is …

us (code pays fourni par la source)

Non-alcoholic Fatty Liver Disease and Depression: Evidence for Genotype × Environment Interaction in Mexican Americans

Eron G. Manusov, Vincent P. Diego, Khalid H. Sheikh, Sandra Laston et autres

This study examines the impact of G × E interaction effects on non-alcoholic fatty liver disease (NAFLD) among Mexican Americans in the Rio Grande Valley (RGV) of South Texas. We examined potential G × E interaction using variance components models and likelihood-based …

us (code pays fourni par la source)

The Prevalence of Glaucoma in the Jirel Ethnic Group of Nepal

Sarah E. Miller, Nicholas B. Blackburn, Matthew P. Johnson, Sandra Laston et autres

Glaucoma is one of the leading causes of blindness worldwide with individuals in Asia disproportionately affected. Using a cross-sectional study design as part of the Jiri Eye Study, we assessed the prevalence of glaucoma in the Jirel population of Nepal and provide …

us, au, np (code pays fourni par la source)

Genetic variants in ALDH1L1 and GLDC influence the serine-to-glycine ratio in Hispanic children

Sergey A. Krupenko, Shelley A. Cole, Ruixue Hou, Karin Haack et autres

us (code pays fourni par la source)

Genetic variants and physical activity interact to affect bone density in Hispanic children

Ruixue Hou, Shelley A. Cole, Mariaelisa Graff, Yujie Wang et autres

BACKGROUND: Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study. METHODS: Physical …

us (code pays fourni par la source)