Genetic variants and physical activity interact to affect bone density in Hispanic children
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Le résumé fourni par la source
BACKGROUND: Our aim was to investigate if moderate to vigorous physical activity (MVPA), calcium intake interacts with bone mineral density (BMD)-related single nucleotide polymorphisms (SNPs) to influence BMD in 750 Hispanic children (4-19y) of the cross-sectional Viva La Familia Study. METHODS: Physical activity and dietary intake were measured by accelerometers and multiple-pass 24 h dietary recalls, respectively. Total body and lumbar spine BMD were measured by dual energy X-ray absorptiometry. A polygenic risk score (PRS) was computed based on SNPs identified in published literature. Regression analysis was conducted with PRSs, MVPA and calcium intake with total body and lumbar spine BMD. RESULTS: ) and lumbar spine BMD (β = - 0.042 ± 0.013, p = 0.0016) in low MVPA group, as compared to high MVPA group (β = - 0.015 ± 0.006, p = 0.02; β = 0.008 ± 0.01, p = 0.4, respectively). DISCUSSION: The study indicated that calcium intake does not modify the relationship between genetic variants and BMD, while it implied physical activity interacts with genetic variants to affect BMD in Hispanic children. Due to limited sample size of our study, future research on gene by environment interaction on bone health and functional studies to provide biological insights are needed. CONCLUSIONS: Bone health in Hispanic children with high genetic risk for low BMD is benefitted more by MVPA than children with low genetic risk. Our results may be useful to predict disease risk and tailor dietary and physical activity advice delivery to people, especially children.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- Genetic variants and physical activity interact to affect bone density in Hispanic children
- Date Crossref
- 15/02/2021
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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University of North Carolina at Chapel Hill Department of Nutrition and Nutrition Research Institute pays non établi dans la noticeUniversité ou école supérieure
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Texas Biomedical Research Institute pays non établi dans la noticeStructure de recherche
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The University of Texas Rio Grande Valley pays non établi dans la noticeUniversité ou école supérieure
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Children's Nutrition Research Center at Baylor College of Medicine USDA/ARS Children's Nutrition Research Center pays non établi dans la noticeOrganisme public
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Obesity Society pays non établi dans la noticeOrganisation à but non lucratif
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University of Texas of the Rio Grande Valley South Texas Diabetes and Obesity Institute and Department of Human Genetics pays non établi dans la noticeUniversité ou école supérieure
Department of Nutrition and Nutrition Research Institute — University of North Carolina at Chapel Hill, Texas Biomedical Research Institute et The University of Texas Rio Grande Valley, avec 3 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.