K. Robert Shen

Ultrasound priming gated by solid tumor hallmarks to guide CAR-T therapy

Tianze Guo, Ziyue Zhu, Yunjia Qu, Xi Yu et autres

CAR-T therapy is highly effective in hematologic malignancies but remains challenging in solid tumors. To address this challenge, here, we developed SHIFTERS (solid-tumor hallmark inducible, focused-ultrasound triggered enhanced reprogramming system), an AND-gated circuit that rewires tumor hallmarks into the clinically validated antigen …

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Viscoelasticity reprograms T cell metabolism for TCR-T cell manufacturing and therapy

Song Li, Youcheng Yang, Yan-Ruide Li, Zeyang Liu et autres

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Impact of Pulmonary Resection Extent on Nodal Upstaging in Clinical Stage IA1-2 NSCLC: Real-World Evidence of Low Detection Rates with Sublobar Resections

Yahya Ahmed Alwatari, Robert Alan Vierkant, Matthew J Aizpuru, Sahar A. Saddoughi et autres

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Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling

Irene Georgakoudi, Melissa C. Skala, Kyle P. Quinn, Chiara Stringari et autres

Significance: Cellular metabolism plays a central role in health and disease, making its study critical for advancing diagnostics and therapies. Label-free optical metabolic imaging using endogenous fluorescence from reduced nicotinamide adenine dinucleotide (phosphate) [NAD(P)H] and flavin adenine dinucleotide (FAD) provides nondestructive, high-resolution …

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Precision Epigenetic Reprogramming: CoREST Inhibition Sensitizes STK11-Mutant Tumors to Immune Checkpoint Blockade Therapy

De‐Chen Lin, K. Robert Shen

Loss-of-function mutations in STK11 (also known as LKB1) define a molecular subtype of non-small cell lung cancer that is resistant to immune checkpoint blockade therapy, partially owing to impaired T-cell infiltration and suppressed antigen presentation. Emerging evidence implicates epigenetic deregulation as a …

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Primary Thoracic Synovial Sarcoma: Results of Treatment at a Single Institution

Matthew Aizpuru, Samuel Earl Broida, Yahya Ahmed Alwatari, Stephen D. Cassivi et autres

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Microfabricated Organ-Specific Models of Tumor Microenvironments

Jeong Min Oh, Yongkuk Park, Jungwoo Lee, K. Robert Shen

Despite the advances in detection, diagnosis, and treatments, cancer remains a lethal disease, claiming the lives of more than 600,000 people in the United States alone in 2024. To accelerate the development of new therapeutic strategies with improved responses, significant efforts have …

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Impact of Frozen Section Pathology Examination of Surgical Margins in Sublobar Pulmonary Resections for Clinical Stage IA Non-small Cell Lung Cancer

Belisario A Ortiz, Sam K Engrav, Anja Christiane Roden, Jennifer M. Boland et autres

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Cost-Effectiveness of Adjuvant Osimertinib With and Without Chemotherapy for Surgically Resected NSCLC

Angelos Vasilopoulos, Ayham M. Odeh, K. Robert Shen, Zaid M. Abdelsattar

Introduction: mutations. Nevertheless, this treatment is lengthy and expensive. Its cost-effectiveness profile as monotherapy versus combination with chemotherapy is unknown. In this context, we investigate the cost-effectiveness of adjuvant osimertinib with and without chemotherapy for NSCLC. Methods: A set of Markov models …

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A micro-metabolic rewiring assay for assessing hypoxia-associated cancer metabolic heterogeneity

Jeong Min Oh, Tianze Guo, Hydari Masuma Begum, Sha Liang et autres

Cancer metabolism plays an essential role in therapeutic resistance, where significant inter- and intra-tumoral heterogeneity exists. Hypoxia is a prominent driver of metabolic rewiring behaviors and drug responses. Recapitulating the hypoxic landscape in the tumor microenvironment thus offers unique insights into heterogeneity …

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Profiling paracrine interactions between hypoxic and normoxic skeletal muscle tissue in a microphysiological system fabricated from 3D printed components

Megan L. Rexius‐Hall, K. Robert Shen, Megan Laura McCain

Disrupted blood flow in conditions such as peripheral artery disease and critical limb ischemia leads to variations in oxygen supply within skeletal muscle tissue, creating regions of poorly perfused, hypoxic skeletal muscle surrounded by regions of adequately perfused, normoxic muscle tissue. These …

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Impact of lymph node evaluation standard in patients undergoing lung resection for clinical stage IA pulmonary adenocarcinoma and squamous cell carcinoma

R.E. Rocco, Brandon S. Hendriksen, Belisario A Ortiz, K. Robert Shen et autres

Background: The American College of Surgeons Commission on Cancer (CoC) revised operative quality standards recommending resection of lymph nodes from at least one hilar station and three different mediastinal stations in all curative-intent pulmonary resections. This study evaluated the prognostic value and …

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