Nicholas E. Vlahakis

64301 Patient-Reported Outcomes in the Phase 2 Studies of ESK-001, an Oral Allosteric TYK2 Inhibitor, in Adults with Moderate-to-Severe Plaque Psoriasis

Andrew Blauvelt, Steven Kempers, Elena Hitraya, Roman G. Rubio et autres

62905 ESK-001, an allosteric TYK2 inhibitor, modulates disease and TYK2-related pathway transcriptomic and proteomic biomarkers in Psoriasis STRIDE trial patients

Nicole Narayan, Joshua Hoffman, Pedro Corpuz, Sibel Ucpinar et autres

0116 ESK-001, an allosteric TYK2 inhibitor, inhibits TYK2-and psoriasis-relevant biomarkers in skin using spatial transcriptomics

Naveen Narayan, Joshua Hoffman, Claire L. Langrish, Sibel Ucpinar et autres

Highly selective, allosteric inhibition of TYK2 with oral ESK-001 in patients with moderate-to-severe plaque psoriasis: Results from STRIDE, a 12-week, randomized, double-blinded, placebo-controlled, dose-ranging phase 2 study

Andrew Blauvelt, Petr Arenberger, Maxwell Sauder, Megan Couvillion et autres

us, cz, ca (code pays fourni par la source)

Impact of Pharmacologically Left Shifting the Oxygen–Hemoglobin Dissociation Curve on Arterial Blood Gases and Pulmonary Gas Exchange During Maximal Exercise in Hypoxia

Glenn M. Stewart, Troy J. Cross, Michael J. Joyner, Steven C. Chase et autres

us, au (code pays fourni par la source)

Voxelotor (GBT440), a Hemoglobin-Oxygen Affinity Modulator, Increases Oxygen Saturation in IPF Patients Who Desaturate with Exercise

Lisa Lancaster, Harold R. Collard, Sandy Dixon, Joseph A. Lasky et autres

us (code pays fourni par la source)

Effects of an allosteric hemoglobin affinity modulator on arterial blood gases and cardiopulmonary responses during normoxic and hypoxic low-intensity exercise

Glenn M. Stewart, Steven C. Chase, Troy J. Cross, Courtney M. Wheatley et autres

us (code pays fourni par la source)

Voxelotor, which left shifts the oxy-hemoglobin dissociation curve, improves oxygen desaturation in IPF patients during maximal exercise

Nicholas E. Vlahakis, Sandy Dixon, Kenneth C. Beck

us (code pays fourni par la source)

Effect of GBT440, an R-State Stabilizer of Hemoglobin, on Hypoxic Maximal Exercise

Glenn M. Stewart, Steven C. Chase, Tom Peete Cross, Briana Ziegler et autres

The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia

Donald M. Arnold, François Lauzier, Martin Albert, David Williamson et autres

ca, au, sa, us (code pays fourni par la source)

GBT1118, a potent allosteric modifier of hemoglobin O2affinity, increases tolerance to severe hypoxia in mice

Kobina Dufu, Özlem Yalçın, Eilleen S. Y. Ao-ieong, Athiwat Hutchaleelala et autres

us, tr (code pays fourni par la source)

Increased hemoglobin-oxygen affinity ameliorates bleomycin-induced hypoxemia and pulmonary fibrosis

Xin Geng, Kobina Dufu, Athiwat Hutchaleelaha, Qing Xu et autres

us (code pays fourni par la source)