Accès ouvert déclaré
2017
article
The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia
Donald M. Arnold, François Lauzier, Martin Albert, David Williamson, Na Li, Ryan Zarychanski, Chip Doig, Andreas Freitag, Mark Crowther, Lois Saunders, France Clarke, Rinaldo Bellomo, Ismael Qushmaq, Renato D. Lópes, Diane Heels‐Ansdell, Kathryn E. Webert, Rick Hall, Graeme Rocker, Lisa Julien, Debbie Wright, Caroline Le Roy, Judy Theriault, Susan Pleasance, Maureen O. Meade, Lori Hand, Christine Wynne, Mark Duffett, Michelle E. Kho, Nicole Zytaruk, John Granton, Paulina Farías, Leslie M. Chu, Nancy Brockest, Stephanie Go, Margaret McGrath‐Chong, Madison Dennis, Marc Lipkus, Emily Stern, Ryan Albert, Stéphan Langevin, Alexis F. Turgeon, Marie‐Claude Tremblay, Martine Blais, Maxime Beauparlant, Julie Asselin, Chantal Gagne, Marie Pierre Thibodeau, Germain Poirier, Sandrine Spearson, Isabelle Neas, Joe Pagliarello, Paul C. Hébert, Irene Watpool, Tracy McArdle, Claude Gaudert, P Marchand, Carson Davidson, Mary‐Jo Lewis, Erin Murphy, Julia Foxall, Yoanna Skrobik, Stefania Chitu, Virginie Williams, Stephanie Dolle, Audrey‐Anne Gosselin, P Deroy, Geeta Mehta, Sumesh Shah, Cheryl Ethier, Sam Tirgari, Lindsay Steinberg, Rod McDonald, Vidhya Sivanantham, Kristofer Bandayrel, Friederike Quittnat Pelletier, Marnie Kramer, Maedean Brown, Scott Kim, Rob Fowler, Nicole Marinoff, Karen I. Code, Boris Bojilov, Derek Parsotam, Marshall John, Orla Smith, Beth Fry, Kerri Porretta, Jeanna Morrissey, Victoria W. Wen, John Muscedere, Miranda Hunt, Susan Fleury, Nicole Godfrey, Sharlene Hammond, Elizabeth K. Mann, M Myers, Amber Robinson, Donald Griesdale, Dean R. Chittock, Vinay Dhingra, Denise Foster, Maureen Gardner, Susan Logie, Roger Autio, D. Wyn Davies, Pia Ganz, Laurie D. Smith, Peter Dodek, Victoria Alcuaz, Betty Jean Ashley, Sheilagh Mans, Niall D. Ferguson, Joel Elman, Timothy Karachi, Tina Millen, Andrea Tkaczyk, Mike Jacka, Marleen Irwin, Carmen Chan, Leeca Sonnema, Kelly Marsh, J.R. Maurer, T. J. Kreidl, Candice Varden, Carey Kinjerski, Christopher Doig, Stacy Ruddell, Linda Knox, Crystal Wilson, Kevin Champagne, Gordon Wood, F. C. Auld, Leslie Atkins, Bojan Paunovic, Nicole Marten, K Wiebe, Ellen McDonald, Steven Reynolds, Miroslav Svetik, Mary Van Osch, Patrica Thompson, Norine Whalen, François Lellouche, M Ferland, Patrick H. Dussault, Caroline Jacob, Marie‐Eve Morneau, Nancy Laberge, Kosar Khwaja, Laura Banici, Carole Sirois, Lena Havell, Olivier Lesur, François Lamontagne, Sandra Proulx, Gerald Hollinger, Vasanti Shende, Vanessa Belcastro, Bill Plaxton, Anders Foss, Jonathan Eisenstat, Tammy Doerle, Michael Sharpe, Mona Madady, Andrew Davies, Shirley Vallance, Cindy Weatherburn, Victoria Bennett, Simon Finfer, Naresh Ramakrishnan, Simon Bird, Julie Potter, Anne O’Connor, Susan Ankers, J. F. J. Cade, Deborah Barge, Tania Caf, Belinda Howe, Glenn M. Eastwood, Leah Peck, Donna Goldsmith, Kim O’Sullivan, David Ernest, Sam Radford, Ann Whitfield, Anthony Cross, Suzanne Eliott, Jaspreet Kaur Sidhu, Inga Mercer, Angela Hamilton, John Botha, Jodi Vuat, Sharon Allsop, Nina Fowler, Tim Crozier, Jonathan Barrett, Chris Wright, Pauline Galt, Carly Culhane, Rebecca Ioannidis, Susan Burton, Marnie Reily, Cyveen Weeraratna, Ian Seppelt, Leonie Weisbrodt, Robyn Bond, Justine Rivett, Stephanie O’Connor, Alexis Poole, Clive Woolfe, Dorrilyn Rajbhandari, Caitlin Rees, John Edington, Jason Fletcher, Julie Smith, Catherine Boschert, Graham Reece, Treena Sara, Kiran Nand, Andrew D. Bersten, Alexander Gallus, Elisha Matheson, Margie O’Callaghan, Neil Orford, Tania Elderkin, Melissa A. Fraser, Allison Bone, Tania Salerno, Anne Kinmonth, Subhash Arora, Bridget O’Bree, Katherine Shepherd, Alan –Quinn, Martin Štěrba, Bronwyn Ruth Johnson, Renee Xu, F. G. H. Hill, Rajaram Ramadoss, Josette Wood, Marcelo Rocha, Andréa Kramer, Martha Hädrich, Nilton Brandão, Cassiano Teixeira, Cíntia Roehrig, Juliana Zeni, Suzana Alves da Silva, Rubens Costa Filho, Renato Girade Corrêa, Alves Moreira, Plínio N. Gomes, Rodrigo Biondi, Otávio Berwanger, Edson Romano, Anna Maria Buehler, Hélio Penna Guimarães, Adriano A. M. Truffa, Rosana Ely Nakamura, Lillian Mazza Barbosa, Jean Brennick, Sawsan Bassi, Mohammed Al‐Sultan, Yaseen M. Arabi, Riette Brits, Jamal A. Alhashemi, Sanaa A. Shalabi, Yasser Mandourah, Nadeem Shaikh, Manal Al‐Hazmi, M. Ali Al‐Azem, Trevor Wyngaard, Barbara Smithson, Nicholas E. Vlahakis, Laurie Meade, Michael J. Cox, Jackie O’Brien, Catherine Krause, Joseph L. Nates, Sajid Haque, Deidre Mooring, Rose Erfe, Paula Nickerson, Tony Sherry, J. L. Smith, Barnaby Sanderson, Josephine Ng, John T. Brooks, Ling Lim, Katie Lei
14Citations signalées, ce qui n’est pas une note de qualité
12Institutions déclarées
4Pays d’affiliation déclarés
Rattachement africain : ca, au, sa, us.
Niveau de preuve : code pays fourni par la source.
Le résumé fourni par la source
Background Platelet transfusions are commonly used to treat critically ill patients with thrombocytopenia. Whether platelet transfusions are associated with a reduction in the risk of major bleeding is unknown. Patients/Methods Observational cohort study nested in a previous multicenter, randomized thromboprophylaxis trial in the intensive care unit (ICU). The objective was to evaluate the association between platelet transfusions and adjudicated major bleeding events. Platelet transfusion episodes were reviewed for timing of administration, product type, and dose. Major bleeding with and without platelet transfusions was adjusted for severity of thrombocytopenia, use of anti‐platelet agents, surgery and other covariates. Secondary outcomes were thrombosis, death in ICU and platelet count increment. Results Among 2,256 patients, 71 (3.1%) received 190 platelet transfusions. Of those, 121 (63.7%) were administered to 54 non‐bleeding, thrombocytopenic patients. Adjusted rates of major bleeding were not statistically different with or without the administration of platelet transfusions (hazard ratio for transfused patients 0.85; 95% confidence interval, 0.42‐1.72). We did not find a significant association between platelet transfusion use and thrombosis or death in ICU in adjusted analyses. Thrombocytopenia, anemia, major or minor bleeding and use of anticoagulants were associated with platelet transfusion administration. The median post‐transfusion platelet count increment was 20×10 9 /L at 3.5 hours post‐transfusion. Conclusions Rates of major bleeding were not different for patients who did and did not receive platelet transfusions. Inferences were limited by the small number of transfused patients. Clinical trials are needed to better investigate the potential hemostatic benefit and potential harms of platelet transfusions for this high‐risk population.
Ce résumé expose les affirmations des auteurs. BNTIC ne l’interprète pas comme une validation indépendante des résultats.
Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The association between platelet transfusions and bleeding in critically ill patients with thrombocytopenia
- Date Crossref
- 01/07/2017
- Éditeur
- Elsevier BV
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Les institutions déclarées
Une affiliation ne permet pas de déduire la nationalité d’un auteur.
Les sujets associés
Blood transfusion and managementPlatelet Disorders and TreatmentsHeparin-Induced Thrombocytopenia and Thrombosis