Yanina Pflüger

Initial report from the SAR-TRACK (SELNET) registry: a multicentric international retrospective analysis on the quality of the management of limb and trunk wall soft-tissue sarcomas (2012–2022) in Ibero-American countries

Javier Martin-Broto, Victor Castro, Antonio Gutierrez, Juan Carlos Haro Varas et autres

Background: Multidisciplinary (MDT) management of sarcoma patients, with adherence to clinical practice guidelines (CPG), has a positive impact on patients' outcomes. Sarcoma European & Latin-American Network (SELNET) is an international consortium aiming to improve sarcoma management in Ibero-America. This study presents data …

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A plain language summary of POLARIS: a study to look at different doses of encorafenib plus binimetinib for people with BRAF V600-mutant melanoma with brain metastasis

Alexander M. Menzies, Georgina V Long, Amiee Kohn, Hussein A. Tawbi et autres

Plain Language SummaryWhat is this summary about?People with a type of melanoma called advanced or metastatic BRAF V600- mutant melanoma, with a change in the BRAF gene, that has spread to the brain have poor outcomes.Current treatments include encorafenib (BRAFTOVI®) and binimetinib …

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Bempegaldesleukin Plus Nivolumab Versus Sunitinib or Cabozantinib in Previously Untreated Advanced Clear Cell Renal Cell Carcinoma: A Phase III Randomized Study (PIVOT-09)

Nizar M. Tannir, Maria Nirvana Formiga, Konstantin Penkov, Nikolay Kislov et autres

PURPOSE Bempegaldesleukin (BEMPEG) is a pegylated interleukin (IL)-2 cytokine prodrug engineered to provide controlled and sustained activation of the clinically validated IL-2 pathway, with the goal of preferentially activating and expanding effector CD8+ T cells and natural killer cells over immunosuppressive regulator …

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POLARIS: A phase 2 trial of encorafenib plus binimetinib evaluating high-dose and standard-dose regimens in patients with BRAF V600-mutant melanoma with brain metastasis

Alexander M. Menzies, Georgina V. Long, Amiee Kohn, Hussein A. Tawbi et autres

Abstract Background POLARIS (phase 2 [ph2]; NCT03911869) evaluated encorafenib (BRAF inhibitor) in combination with binimetinib (MEK1/2 inhibitor) in BRAF/MEK inhibitor-naïve patients with BRAF V600-mutant melanoma with asymptomatic brain metastases. Methods The safety lead-in (SLI) assessed tolerability for high-dose encorafenib 300 mg twice …

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Generalized Lymphatic Anomaly as a Differential Diagnosis of Lytic Lesions

Greta Catani, Federico Waisberg, Diego Enrico, Andrés Rodríguez et autres

Generalized lymphatic anomaly (GLA) is an infrequent multiorgan disease characterized by the presence of abnormal proliferation of lymphatic vessels. The diagnosis requires histological confirmation, and the treatment is controversial. We are presenting a case of a 28-year-old male patient who was diagnosed …

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Desmoid tumour in an inguinal hernia in a patient with a previous diagnosis of melanoma

Natalia Soledad Tissera, Yanina Pflüger, Federico Waisberg, Martín Ángel et autres

A 68-year-old man, without a family history of cancer, was treated for primary cutaneous melanoma of the scalp. Two years later, a right lateral cervical lymph recurrence was observed and he was treated with lymphadenectomy and adjuvant nivolumab for 1 year. Four …

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SELNET clinical practice guidelines for bone sarcoma

Jean‐Yves Blay, Emanuela Palmerini, Julien Bollard, Samuel Aguiar et autres

Bone sarcoma are infrequent diseases, representing < 0.2% of all adult neoplasms. A multidisciplinary management within reference centers for sarcoma, with discussion of the diagnostic and therapeutic strategies within an expert multidisciplinary tumour board, is essential for these patients, given its heterogeneity …

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SELNET clinical practice guidelines for soft tissue sarcoma and GIST

Jean‐Yves Blay, Nadia Hindi, Julien Bollard, Samuel Aguiar et autres

Americanae nace como un proyecto conjunto que surge dentro de la Red Europea de Información y Documentación sobre América Latina (REDIAL), y que ha afrontado la Biblioteca de la Agencia Española de Cooperación Internacional para el Desarrollo (AECID). Esta nueva biblioteca virtual …

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Uncommon Subtypes of Malignant Melanomas: A Review Based on Clinical and Molecular Perspectives

Matías Chacón, Yanina Pflüger, Martín Ángel, Federico Waisberg et autres

Malignant melanoma represents the most aggressive type of skin cancer. Modern therapies, including targeted agents and immune checkpoint inhibitors, have changed the dismal prognosis that characterized this disease. However, most evidence was obtained by studying patients with frequent subtypes of cutaneous melanoma …

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Cáncer renal. Descripción poblacional en una institución académica

Matías Chacón, Yanina Pflüger, Alberto Villaronga, Agustín Falco et autres

El conocimiento en cáncer renal ha sido manifiesto en la última década, con adelantos que optimizan el abordaje diagnóstico, quirúrgico y terapéutico con agentes dirigidos contra blancos específicos. El objetivo del trabajo fue la evaluación retrospectiva de pacientes con cáncer de riñón, …

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Enfoque multidisciplinario sobre el tratamiento delcáncer renal en una institución oncológica

Gustavo Villoldo, Matías Chacón, Fernando Caumont, Juan Pablo Caprini et autres

Introduccion: Los adelantos en el conocimiento sobre cancer renal han optimizado el abordaje diagnostico, quirurgico y terapeutico mediante la creacion de agentes contra blancos especificos. Objetivos: Evaluar pacientes con cancer renal destacando datos demograficos, patologicos, quirurgicos, de recurrencia y las modalidades terapeuticas …

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Enfoque multidisciplinario sobre el tratamiento del cáncer renal en una institución oncológica Multidisciplinary approach to the treatment of renal cancer in an oncology institution

Gustavo Villoldo, Matías Chacón, Fernando Caumont, Juan Pablo Caprini et autres