Tom Winkler

p53 inactivation drives breast cancer metastasis to the brain through SCD1 upregulation and increased fatty acid metabolism

Kathrin Laue, Sabina Pozzi, Johanna Zerbib, Rebecca Bertolio et autres

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Chromosome-arm 17p Loss Renders Breast Cancer Cells Vulnerable to AURKB Inhibition

Tom Winkler, Eran Sdeor, Ron Saad, Hajime Okada et autres

Abstract Loss of chromosome-arm 17p (Del17p) is a genetic hallmark of breast cancer. While TP53 loss is an established driver of Del17p, the potential therapeutically-relevant cellular vulnerabilities of this common aneuploidy remain unexplored. Here, we first analyzed genomic and clinical data from …

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p53 is a selective barrier to chromosome loss in cancer

Joana F. Marques, Marco António Dias Louro, Michaël Schubert, Tom Winkler et autres

Abstract Aneuploidy and TP53 mutations are among the most frequent genetic alterations in cancer. p53 inactivation is widely considered a key enabling event for aneuploidy emergence. However, whether p53 protects against specific types of aneuploidy, and whether this is universal across cancer …

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A recombinant hybrid provides insights into gene regulation, pathogenesis, and tumorigenesis of phytopathogenic smut fungi

J.A. Werner, Weiliang Zuo, Tom Winkler, Gunther Doehlemann

The closely related maize smut fungi Ustilago maydis and Sporisorium reilianum share genome structures but differ in their pathogenic behavior. U. maydis causes local tumors, while S. reilianum spreads systemically and affects inflorescences. To investigate the genetic basis of these differences, we …

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A recombinant hybrid provides insights into gene regulation, pathogenesis and tumorigenesis of phytopathogenic smut fungi

J.A. Werner, Weiliang Zuo, Tom Winkler, Gunther Doehlemann

Abstract The maize smut fungi Ustilago maydis and Sporisorium reilianum are closely related and have similar genomes in terms of size and synteny. While U. maydis induces tumors locally at sites of infection, S. reilianum systemically colonizes the host and causes symptoms …

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CCL2 blockade combined with PD-1/P-selectin immunomodulators impedes breast cancer brain metastasis

Sahar Israeli Dangoor, Rami Khoury, K. Salomon, Sabina Pozzi et autres

Over the last two decades, the diagnosis and treatment of breast cancer patients have improved considerably. However, brain metastases remain a major clinical challenge and a leading cause of mortality. Thus, a better understanding of the pathways involved in the metastatic cascade …

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Abstract B003: Identification of novel genes that regulate aneuploidy tolerance by attenuating aneuploidy-induced stresses

Yonatan Eliezer, Adi V Tarrab, Tal Ben-Yishay, Hajime Okada et autres

Abstract Aneuploidy, an imbalanced number of chromosomes or chromosome arms, is the most common genetic aberration in cancer and is associated with a worse prognosis and advanced disease. However, in non-transformed cells, aneuploidy has a substantial fitness cost, leading to cell cycle …

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Inactivation of p53 drives breast cancer brain metastasis by altering fatty acid metabolism

Kathrin Laue, Sabina Pozzi, Yael Cohen‐Sharir, Tom Winkler et autres

Abstract Brain metastasis (BM) is a dire prognosis across cancer types. It is largely unknown why some tumors metastasize to the brain whereas others do not. We analyzed genomic and transcriptional data from clinical samples of breast cancer BM (BCBM) and found …

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The effect of non-oncology drugs on clinical and genomic risk in early luminal breast cancer

B Waissengrin, T Zahavi, M Salmon-Divon, Alexander A. Goldberg et autres

BACKGROUND: An effect of non-oncology medications on cancer outcome has been proposed. In this study, we aimed to systematically examine the impact of commonly prescribed non-oncology drugs on clinical risk and on the genomic risk [based on the Oncotype DX recurrence score …

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Elevated expression of ACE2 in tumor‐adjacent normal tissues of cancer patients

Tom Winkler, Uri Ben‐David

Dear editor, The recent outbreak of a novel betacoronavirus known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has raised the concern that cancer patients might be particularly susceptible to infection by this virus.1-3 Importantly, the guidelines for cancer patients during the …

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Elevated expression of ACE2 in tumor-adjacent normal tissues of cancer patients

Tom Winkler, Uri Ben‐David

Abstract The rapidly developing COVID-19 pandemic has raised a concern that cancer patients may have increased susceptibility to SARS-CoV-2 infection. This discussion has mostly focused on therapy-induced immune suppression. Here, we examined the expression patterns of ACE2 , the receptor through which …

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