Eran Sdeor

Chromosome-arm 17p Loss Renders Breast Cancer Cells Vulnerable to AURKB Inhibition

Tom Winkler, Eran Sdeor, Ron Saad, Hajime Okada et autres

Abstract Loss of chromosome-arm 17p (Del17p) is a genetic hallmark of breast cancer. While TP53 loss is an established driver of Del17p, the potential therapeutically-relevant cellular vulnerabilities of this common aneuploidy remain unexplored. Here, we first analyzed genomic and clinical data from …

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Aneuploidy as a driver of human cancer

Eran Sdeor, Hajime Okada, Ron Saad, Tal Ben-Yishay et autres

il, us (code pays fourni par la source)

Abstract PR008: Targeting mechanisms of dosage compensation to selectively kill aneuploid cancer cells

Hajime Okada, Eran Sdeor, Miriam Karmon, Erez Y. Levanon et autres

Abstract Aneuploidy is an abnormal chromosome composition and a general hallmark of human cancer. Aneuploidy causes detrimental cellular stresses, but cancer cells evolve to cope with these stresses. Consequently, targeting such mitigation mechanisms is a promising potential therapeutic strategy. As an abnormal …

il (code pays fourni par la source)