Accès ouvert
2021
article
OpenAlex
Sara B. York, Li Jun Sun, Allaura S. Cone, Leanne C. Duke et autres
Zika virus is a reemerging infectious disease that spread rapidly across the Caribbean and South America. Infection of pregnant women during the first trimester has been linked to microcephaly, a neurological condition where babies are born with smaller heads due to abnormal …
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Accès ouvert
2021
article
OpenAlex
Mujeeb R. Cheerathodi, Dingani Nkosi, Allaura S. Cone, Sara B. York et autres
Tetraspanin CD63 is a cluster of cell surface proteins with four transmembrane domains; it is associated with tetraspanin-enriched microdomains and typically localizes to late endosomes and lysosomes. CD63 plays an important role in the cellular trafficking of different proteins, EV cargo sorting, …
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Accès ouvert
2021
preprint
OpenAlex
Sara B. York, Li Jun Sun, Allaura S. Cone, Leanne C. Duke et autres
ABSTRACT Extracellular vesicles (EVs) are membrane-encapsulated structures released by cells which carry signaling factors, proteins and microRNAs that mediate intercellular communication. Accumulating evidence supports an important role of EVs in the progression of neurological conditions and both the spread and pathogenesis of …
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Accès ouvert
2021
preprint
OpenAlex
Mujeeb R. Cheerathodi, Dingani Nkosi, Allaura S. Cone, Sara B. York et autres
Abstract Tetraspanin CD63 is a cluster of cell surface proteins with four transmembrane domains which associates with tetraspanin-enriched microdomains and typically localizes to late endosomes and lysosomes. CD63 plays an important role in cellular trafficking of different proteins, EV cargo sorting and …
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2019
book-chapter
OpenAlex
Mujeeb R. Cheerathodi, David G. Meckes
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Accès ouvert
2019
article
OpenAlex
Mark Marzano, Julie Bejoy, Mujeeb R. Cheerathodi, Li Jun Sun et autres
Extracellular vesicles (EVs) contribute to a variety of signaling processes and the overall physiological and pathological states of stem cells and tissues. Human induced pluripotent stem cells (hiPSCs) have unique characteristics that can mimic embryonic tissue development. There is growing interest in …
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Accès ouvert
2018
article
OpenAlex
Mujeeb R. Cheerathodi, David G. Meckes
The oncogenic potential of Epstein-Barr virus (EBV) is mostly attributed to latent membrane protein 1 (LMP1), which is essential and sufficient for transformation of fibroblast and primary lymphocytes. LMP1 expression results in the activation of multiple signaling cascades like NF-ΚB and MAP …
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Accès ouvert
2018
article
OpenAlex
Dingani Nkosi, Lauren A. Howell, Mujeeb R. Cheerathodi, Stephanie N. Hurwitz et autres
EBV infection contributes to the development of cancers, such as nasopharyngeal carcinoma, Burkitt lymphoma, Hodgkin's disease, and posttransplant lymphomas, in immunocompromised or genetically susceptible individuals. LMP1 is an important viral protein expressed by EBV in these cancers. LMP1 is secreted in extracellular …
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Accès ouvert
2018
article
OpenAlex
Mark A. Rider, Mujeeb R. Cheerathodi, Stephanie N. Hurwitz, Dingani Nkosi et autres
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Accès ouvert
2017
article
OpenAlex
Stephanie N. Hurwitz, Mujeeb R. Cheerathodi, Dingani Nkosi, Sara B. York et autres
ABSTRACT The tetraspanin protein CD63 has been recently described as a key factor in extracellular vesicle (EV) production and endosomal cargo sorting. In the context of Epstein-Barr virus (EBV) infection, CD63 is required for the efficient packaging of the major viral oncoprotein …
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