Yingying Jiang

The role of SAM-dependent internal m7G modification of LINC01252 in the progression of hepatocellular carcinoma

Xuehan Zhao, Min Shi, Li Zhao, Yingying Jiang et autres

Abstract Dysregulation of long non-coding RNAs (lncRNAs) plays a significant role in the progression of hepatocellular carcinoma (HCC), yet many underlying mechanisms remain elusive. Recent studies have highlighted the critical importance of internal N 7 -methylguanosine (m 7 G) modifications in influencing …

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METTL3- and IGF2BP1-associated m6A regulation of FADS2 contributes to lipid droplet accumulation and malignant progression in non-small cell lung cancer

Yu Zhang, L Wang, Huanhuan Xu, Leping Fang et autres

Background: Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related mortality worldwide, and its underlying molecular mechanisms remain incompletely defined. N6-methyladenosine (m6A) RNA modification has emerged as a key epigenetic regulator of tumor metabolic reprogramming. However, the roles of the …

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Ultrasound-Assisted Radiopharmaceutical Investigation of GNL1-Mediated AKT-P53-P21 Axis Activation in Cervical Cancer Progression

Yingying Jiang, Jing Ren, Junzhen Tao

Background: Cervical cancer is a leading cause of cancer death in women worldwide, and the outcomes for advanced or recurrent disease remain poor. Ultrasound-assisted delivery could increase intratumoral uptake of radiopharmaceuticals, but prospective clinical evidence and risk data are limited. Methods: In …

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Comprehensive Analysis of N7-Methylguanosine-Modified Long Non-Coding RNAs Identifies DPY19L1P1 as a Key Oncogenic Effector in Oral Squamous Cell Carcinoma

Kexin Liang, Hui Gong, Simiao Bian, Huiyang Xu et autres

Background: N7-methylguanosine (m7G) is an important RNA modification involved in the regulation of gene expression during transcription. While its roles in mRNAs and tRNAs are increasingly understood, the distribution and function of m7G in long non-coding RNAs (lncRNAs), particularly in oral squamous …

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The role of positive feedback loop between LINC00862 and RBM47 in hepatocellular carcinoma suppression

Tao Guo, Yingying Jiang, Min Xian Shi, Linying Sun et autres

While the dynamic interaction between long non-coding RNA (lncRNA) and RNA binding proteins is widely recognized as pivotal in the regulation of hepatocellular carcinoma (HCC), the precise underlying mechanisms and networks governing their effects remain elusive. Here, we have uncovered LINC00862, a …

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Multi-omics analyses develop and validate the optimal prognostic model on overall survival prediction for resectable hepatocellular carcinoma

Ying Mei Han, Ajuan Zeng, Xueying Sharon Liang, Yingying Jiang et autres

Background: Prediction of prognosis in patients with hepatocellular carcinoma (HCC) by single-omics profiling has been widely studied. However, the prognosis related to biomarkers of multiple omics has not been investigated. We aimed to establish and validate a prediction model for prognosis prediction …

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The potential role of tumor deposits in the prognosis and TNM staging for colorectal cancer

Xinhong Shi, Linlin Lu, Zihan Wang, Yingying Dai et autres

Background: Tumor deposits (TDs) can impact proper staging of cancer, which is crucial for discussing prognosis and determining the appropriate treatment plan. Our study aimed to correlate how TDs influence prognosis of resected colorectal cancer (CRC) and how to optimize tumor-node-metastasis (TNM) …

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Vitamin D can mitigate sepsis-associated neurodegeneration by inhibiting exogenous histone-induced pyroptosis and ferroptosis: Implications for brain protection and cognitive preservation

Yibing Sun, PU Zhi-lin, Hailin Zhao, Yuxuan Deng et autres

BACKGROUND: Sepsis-induced neurodegeneration and cognitive dysfunction remain critical challenges worldwide. Vitamin D was reported to reduce neuronal injury and neurotoxicity and its deficiency was associated with neurocognitive disorders. This study investigates the mechanisms by which vitamin D exerts neuroprotective potential against damage-associated …

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Effect of diode laser on oral pigmentation, pain, and wound healing in patients with gingival hyperpigmentation: a meta-analysis.

Wentian Zheng, Yongzhi Pang, Hui Qi Gong, Min Yan Shi et autres

OBJECTIVES: Diode laser represents a practical clinical strategy for treating gingival hyperpigmentation. However, its effectiveness remains controversial. The aim of this meta-analysis was to evaluate the quantitative effects of diode laser therapy on gingival hyperpigmentation. METHOD AND MATERIALS: PubMed, Embase, Web of …

Hydrogels for Nucleic Acid Drugs Delivery

Jiaping Liu, Ziyue Xi, Chuanyong Fan, Yihua Mei et autres

Nucleic acid drugs are one of the hot spots in the field of biomedicine in recent years, and play a crucial role in the treatment of many diseases. However, its low stability and difficulty in target drug delivery are the bottlenecks restricting …

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Evaluating the validity of eye-tracking tasks and stimuli in detecting high-risk infants later diagnosed with autism: A meta-analysis

Wenwen Hou, Yingying Jiang, Yunmei Yang, Liqi Zhu et autres

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Unveiling the Deadly Effects of Hydrogen Cyanamide Poisoning: A Case Report

Yuanwen Ye, Linglong Chen, Baohua YANG, B.-Z. Li et autres

Unveiling the Deadly Effects of Hydrogen Cyanamide Poisoning: A Case ReportAbstract: Hydrogen cyanamide is commonly employed in agricultural practices, leading to frequent occurrences of related poisoning incidents. However, severe cases of hydrogen c

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