The role of SAM-dependent internal m7G modification of LINC01252 in the progression of hepatocellular carcinoma
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Le résumé fourni par la source
Abstract Dysregulation of long non-coding RNAs (lncRNAs) plays a significant role in the progression of hepatocellular carcinoma (HCC), yet many underlying mechanisms remain elusive. Recent studies have highlighted the critical importance of internal N 7 -methylguanosine (m 7 G) modifications in influencing RNA expression and function. In this study, we identified LINC01252, a poorly characterized lncRNA, through analyses of GEO datasets and the TCGA cohort. Notably, LINC01252 is downregulated in HCC tissues and is associated with prognostic outcomes, although the predictive value of a nomogram based on LINC01252 expression characteristics appears to be limited. Our results indicate that LINC01252 effectively inhibits tumorigenic behaviors in HCC and exerts its effects by targeting the oncogene NUPR1. Mechanistically, LINC01252 acts as an intranuclear lncRNA that binds to the NUPR1 promoter through Hoogsteen pairing, consequently inhibiting its transcriptional activity. Additionally, the internal m 7 G modification level of LINC01252 directly influences its RNA stability, contingent upon sufficient concentrations of S-adenosylmethionine (SAM), which is necessary for the activity of its key modifying enzymes, METTL1 and WDR4. Thus, LINC01252’s m 7 G modification and expression are SAM-dependent in the context of HCC. Furthermore, LINC01252 can also suppress WDR4 transcription by binding to its promoter through the same mechanism, thus inhibiting HCC progression. Our findings suggest that LINC01252 functions as a SAM-dependent, m 7 G-related lncRNA, acting as a transcriptional repressor of NUPR1 and WDR4, while establishing a negative feedback loop between LINC01252 and WDR4. However, the potential of LINC01252 as a clinical biomarker still requires further investigation.
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Le contrôle bibliographique ouvert
DOI retrouvé dans Crossref DOI retrouvé ; titre concordant.
- Titre Crossref
- The role of SAM-dependent internal m7G modification of LINC01252 in the progression of hepatocellular carcinoma
- Date Crossref
- 24/08/2026
- Éditeur
- Springer Science and Business Media LLC
- Type
- journal-article
Ce recoupement confirme des métadonnées liées au DOI. Il ne confirme ni la méthode ni les conclusions de l’étude, et il ne compte pas comme une seconde source scientifique indépendante.
Où se fait cette recherche
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Weifang Medical University pays non établi dans la noticeUniversité ou école supérieure
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Wuhan University Department of Hepatobiliary and Pancreatic Surgery pays non établi dans la noticeUniversité ou école supérieure
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Zhongnan Hospital of Wuhan University pays non établi dans la noticeÉtablissement de santé
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Second Hospital of Shandong University pays non établi dans la noticeÉtablissement de santé
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School of Basic Medical Sciences Department of Pathophysiology pays non établi dans la noticeUniversité ou école supérieure
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School of Laboratory Medicine Department of Clinical Microbiology pays non établi dans la noticeUniversité ou école supérieure
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School of Stomatology pays non établi dans la noticeUniversité ou école supérieure
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School of Public Health pays non établi dans la noticeUniversité ou école supérieure
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Affiliated Hospital of Shandong Second Medical University Department of Hepatobiliary and Pancreatic Surgery pays non établi dans la noticeUniversité ou école supérieure
Weifang Medical University, Department of Hepatobiliary and Pancreatic Surgery — Wuhan University et Zhongnan Hospital of Wuhan University, avec 6 autres affiliations.
Une affiliation ne permet pas de déduire la nationalité d’un auteur.