Shinnosuke Yamada

Core Activation Program and Selective Regional Responsiveness of Microglia in Aging and Parabiosis

Huma Naz, Róbert Pálovics, Shinnosuke Yamada, Nannan Lu et autres

Aging is associated with immune dysregulation in brain and is the biggest risk factor for many neurodegenerative diseases whereas rejuvenation interventions can mediate beneficial effects. Microglia are considered as a major player in the development of neurodegenerative disease yet, the molecular changes …

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FATP1-mediated fatty acid uptake in renal tubular cells as a countermeasure for hypothermia

Kie Horioka, Hiroki Tanaka, Shimpei Watanabe, Shinnosuke Yamada et autres

Hypothermia is a condition in which body temperature falls below 35 °C, resulting from exposure to low environmental temperatures or underlying medical conditions. Postmortem examinations have revealed increased levels of fatty acids in blood and lipid droplet formation in renal tubules during …

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Manufacturing Processes and Powder Property of Metal Powders for Additive Manufacturing

Shinnosuke Yamada

Recently, Additive Manufacturing (AM) has been attracting attention as the breakthrough manufacturing technology and is being aggressively researched and developed around the world. Metal AM enables the integration of parts with complex 3D internal structures, such as topology optimization and lattice structures, …

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Plasma acellular transcriptome contains Parkinson’s disease signatures that can inform clinical diagnosis

Aleksandra Beric, Alejandro Cisterna‐García, Charissa Martin, Ravindra Kumar et autres

ABSTRACT We aimed to identify plasma cell-free transcripts (cfRNA) associated with Parkinson’s disease (PD) that also have a high predictive value to differentiate PD from healthy controls. Leveraging two independent populations from two different movement disorder centers we identified 2,188 differentially expressed …

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Persistent median artery: paedogenesis of the antebrachial arterial system in the human body

Shinnosuke Yamada, Kyutaro Kawagishi, Takaya Ishii, Hidenobu Miyaso et autres

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Regulation of lymphoid-myeloid lineage bias through regnase-1/3-mediated control of Nfkbiz

Takuya Uehata, Shinnosuke Yamada, Daisuke Ori, Alexis Vandenbon et autres

ABSTRACT: Regulation of lineage biases in hematopoietic stem and progenitor cells (HSPCs) is pivotal for balanced hematopoietic output. However, little is known about the mechanism behind lineage choice in HSPCs. Here, we show that messenger RNA (mRNA) decay factors regnase-1 (Reg1; Zc3h12a) …

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Influence of Oxygen Concentration in Building Environment and Oxidation Extent of Maraging Steel on Spatter Generation Behavior in Powder Bed Fusion

Mitsugu Yamaguchi, Kotaro Tsubouchi, Asako Kamimoto, Shinnosuke Yamada et autres

This study investigated the influence of oxygen concentration in the building environment and the degree of oxidation of maraging steel powder on spatter generation behavior during powder bed fusion (PBF) process. The powders were oxidized at various heat treatment temperatures, and their …

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Human striatal glia differentially contribute to AD- and PD-specific neurodegeneration

Jinbin Xu, Huifangjie L. Farsad, Yiran Hou, Kia M. Barclay et autres

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Bioprotective role of platelet-derived microvesicles in hypothermia: Insight into the differential characteristics of peripheral and splenic platelets

Kie Horioka, Hiroki Tanaka, Keisuke Okaba, Shinnosuke Yamada et autres

BACKGROUND: Most platelets are present in peripheral blood, but some are stored in the spleen. Because the tissue environments of peripheral blood vessels and the spleen are quite distinct, the properties of platelets present in each may also differ. However, no studies …

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Effect of Powder Shear Property on PBF-LB/M Powder Bed Quality of Tool Steels

Shinnosuke Yamada, Mitsugu Yamaguchi, Tatsuaki FURUMOTO

The Additive Manufacturing (AM) die & mold, which has conformal cooling channel manufactured by PBF-LB/M process, will be deliver high performance in terms of improvement of thermal fatigue. In tool steel SKD61 for AM die & mold often occurs surface crack due …

A novel categorization of the muscular branches of the tibial nerve within the popliteal fossa

Takaya Ishii, Kyutaro Kawagishi, Shogo Hayashi, Shinnosuke Yamada et autres

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Functional importance of the mandibular skeleto-muscular system in the bivalved arthropod Heterocypris incongruens (Crustacea, Ostracoda, Cyprididae)

Shinnosuke Yamada

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