Changyi Cui

Live-Cell Monitoring and Omics Analysis of Liquid–Solid Transitions of Biomolecular Condensates

Asmaa M. A. S. Farrag, Koshiro Ota, Hideaki� Yoshimura, Misao Takemoto et autres

Biomolecular condensates, or so-called membraneless organelles, transition from liquid into more solid-like states over time, contributing to the development of pathological conditions. The present study proposes a simple method using photoactive yellow protein (PYP) and its specific fluorescent covalent ligands to distinguish …

jp, ru, lk, bg, es, Égypte, us, cn, pl (code pays fourni par la source)

Discovery of a self-assembling small molecule that sequesters RNA-binding proteins

Hyoseok Kim, Changyi Cui, Kohei Toh, Genyir Ado et autres

kr, jp, cn (code pays fourni par la source)

Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe

Ye‐Jin Jung, Naotaka Noda, Junichiro Takaya, Masahiro Abo et autres

Covalent inhibitors of enzymes are increasingly appreciated as pharmaceutical seeds, yet discovering non-cysteine-targeting inhibitors remains challenging. Herein, we report an intriguing experience during our activity-based proteomic screening of 1601 reactive small molecules, in which we monitored the ability of library molecules to …

jp, cn (code pays fourni par la source)

Diversity-oriented synthesis of pyrazoles derivatives from flavones and isoflavones leads to the discovery of promising reversal agents of fluconazole resistance in Candida albicans

Changyi Cui, Jun Liu, Hongbo Zheng, Xueyang Jin et autres

cn (code pays fourni par la source)

Discovery of Potent Orally Active Protease-Activated Receptor 1 (PAR1) Antagonists Based on Andrographolide

Jun Liu, Bin Sun, Xiaoyu Zhao, Jie Xing et autres

Protease-activated receptor-1 (PAR1), a G-protein-coupled receptor, plays a critical role in thrombin-mediated platelet aggregation. It is regarded as a promising antithrombosis target that is unlikely to result in bleeding. Here, we describe the synthesis of a series of novel PAR1 antagonists by …

cn (code pays fourni par la source)

Synthesis and Anti-inflammatory Activity of 6H-1,2-Oxathiacyclohexano[5,6-c]Isobenzopyran Derivatives

Jin‐Jun Wang, Changyi Cui, Guang‐Fan Han, Yonghui Wei et autres

Synthesis and Anti-inflammatory Activity of 6H-1,2-Oxathiacyclohexano[5,6-c]Isobenzopyran Derivatives

Jin‐Jun Wang, Changyi Cui, Guang‐Fan Han, Yonghui Wei et autres