Colm Atkins

SIRT1 remodels astrocyte metabolism and promotes viral replication during neurotropic orthoflavivirus infection

Juan P. Angel, Diego Alzate, Marissa Lindman, Colm Atkins et autres

Orthoflaviviruses depend on host metabolic resources to replicate, but how distinct cell types in the central nervous system (CNS) alter their metabolism in response to infection remains incompletely understood. Here, we examined whether the NAD+-dependent deacetylase SIRT1 is engaged during Zika virus …

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Inapparent maternal ZIKV infection impacts fetal brain development and postnatal behavior

Tsui-Wen Chou, Micheal McCourt, Eduard Marmut, Vishal Karuppusamy et autres

Zika virus (ZIKV) has emerged as a significant public health concern due to its association with severe neurological outcomes in infants, including microcephaly and congenital Zika syndrome (CZS). However, while the majority of ZIKV infections during pregnancy do not result in CZS, …

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Astrocytic RIPK3 exerts protective anti-inflammatory activity in mice with viral encephalitis by transcriptional induction of serpins

Marissa Lindman, Irving Estevez, Eduard Marmut, Evan M. DaPrano et autres

Flaviviruses pose a substantial threat to public health because of their ability to infect the central nervous system (CNS). Receptor-interacting protein kinase 3 (RIPK3) is a central coordinator that promotes neuroinflammation during viral infection of the CNS, a role that occurs independently …

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The kinase RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during central nervous system viral infection

Irving Estevez, Benjamin D. Buckley, Marissa Lindman, Nicholas Panzera et autres

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Astrocytic RIPK3 exerts protective anti-inflammatory activity during viral encephalitis via induction of serpin protease inhibitors

Marissa Lindman, Irving Estevez, Eduard Marmut, Evan M. DaPrano et autres

Flaviviruses pose a significant threat to public health due to their ability to infect the central nervous system (CNS) and cause severe neurologic disease. Astrocytes play a crucial role in the pathogenesis of flavivirus encephalitis through their maintenance of blood-brain barrier (BBB) …

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Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

Nydia P. Chang, Evan M. DaPrano, Marissa Lindman, Irving Estevez et autres

Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. Receptor interacting protein kinase-3 (RIPK3) signaling has recently been described as a key regulator of neuroinflammation, but whether …

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RIPK3 promotes neuronal survival by suppressing excitatory neurotransmission during CNS viral infection

Irving Estevez, Benjamin D. Buckley, Nicholas Panzera, Marissa Lindman et autres

While recent work has identified roles for immune mediators in the regulation of neural activity, the capacity for cell intrinsic innate immune signaling within neurons to influence neurotransmission remains poorly understood. However, the existing evidence linking immune signaling with neuronal function suggests …

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RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

Marissa Lindman, Juan P. Angel, Irving Estevez, Nydia P. Chang et autres

Innate immune signaling in the central nervous system (CNS) exhibits many remarkable specializations that vary across cell types and CNS regions. In the setting of neuroinvasive flavivirus infection, neurons employ the immunologic kinase receptor-interacting kinase 3 (RIPK3) to promote an antiviral transcriptional …

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Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

Nydia P. Chang, Evan M. DaPrano, Wesley R. Evans, Marialaina Nissenbaum et autres

Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. RIPK3 signaling has recently been described as a key regulator of neuroinflammation, but whether this kinase mediates astrocytic …

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Nipah Virus Bangladesh Infection Elicits Organ-Specific Innate and Inflammatory Responses in the Marmoset Model

Christian S. Stevens, Jake E. Lowry, Terry L. Juelich, Colm Atkins et autres

The common marmoset (Callithrix jacchus) is increasingly recognized as an ideal nonhuman primate (NHP) at high biocontainment due to its smaller size and relative ease of handling. Here, we evaluated the susceptibility and pathogenesis of Nipah virus Bangladesh strain (NiVB) infection in …

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RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

Marissa Lindman, Juan P. Angel, Irving Estevez, Nydia P. Chang et autres

Abstract Innate immune signaling in the central nervous system (CNS) exhibits many remarkable specializations that vary across cell types and CNS regions. In the setting of neuroinvasive flavivirus infection, neurons employ the immunologic kinase receptor-interacting kinase 3 (RIPK3) to promote an antiviral …

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Ubiquitination of Ebola virus VP35 at lysine 309 regulates viral transcription and assembly

Sarah van Tol, Birte Kalveram, Philipp A. Ilinykh, Adam J. Ronk et autres

Ebola virus (EBOV) VP35 is a polyfunctional protein involved in viral genome packaging, viral polymerase function, and host immune antagonism. The mechanisms regulating VP35's engagement in different functions are not well-understood. We previously showed that the host E3 ubiquitin ligase TRIM6 ubiquitinates …

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