Nydia P. Chang

Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

Nydia P. Chang, Evan M. DaPrano, Marissa Lindman, Irving Estevez et autres

Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. Receptor interacting protein kinase-3 (RIPK3) signaling has recently been described as a key regulator of neuroinflammation, but whether …

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RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

Marissa Lindman, Juan P. Angel, Irving Estevez, Nydia P. Chang et autres

Innate immune signaling in the central nervous system (CNS) exhibits many remarkable specializations that vary across cell types and CNS regions. In the setting of neuroinvasive flavivirus infection, neurons employ the immunologic kinase receptor-interacting kinase 3 (RIPK3) to promote an antiviral transcriptional …

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Neuronal DAMPs exacerbate neurodegeneration via astrocytic RIPK3 signaling

Nydia P. Chang, Evan M. DaPrano, Wesley R. Evans, Marialaina Nissenbaum et autres

Astrocyte activation is a common feature of neurodegenerative diseases. However, the ways in which dying neurons influence the activity of astrocytes is poorly understood. RIPK3 signaling has recently been described as a key regulator of neuroinflammation, but whether this kinase mediates astrocytic …

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RIPK3 promotes brain region-specific interferon signaling and restriction of tick-borne flavivirus infection

Marissa Lindman, Juan P. Angel, Irving Estevez, Nydia P. Chang et autres

Abstract Innate immune signaling in the central nervous system (CNS) exhibits many remarkable specializations that vary across cell types and CNS regions. In the setting of neuroinvasive flavivirus infection, neurons employ the immunologic kinase receptor-interacting kinase 3 (RIPK3) to promote an antiviral …

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Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders

Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang et autres

BACKGROUND: Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but serious neurologic disease in adults. However, the potential …

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Zika virus-induced TNF-α signaling dysregulates expression of neurologic genes associated with psychiatric disorders

Po-Lun Kung, Tsui-Wen Chou, Marissa Lindman, Nydia P. Chang et autres

Abstract Zika virus (ZIKV) is an emerging flavivirus of global concern. ZIKV infection of the central nervous system has been linked to a variety of clinical syndromes, including microcephaly in fetuses and rare but serious neurologic disease in adults. However, the potential …

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Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB

Tsui-Wen Chou, Nydia P. Chang, Medha Krishnagiri, Aisha P. Patel et autres

Parkinson's disease (PD) is a neurodegenerative disorder characterized by the death of midbrain dopamine neurons. The pathogenesis of PD is poorly understood, though misfolded and/or aggregated forms of the protein α-synuclein have been implicated in several neurodegenerative disease processes, including neuroinflammation and …

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Fibrillar α-synuclein induces neurotoxic astrocyte activation via RIP kinase signaling and NF-κB

Tsui-Wen Chou, Nydia P. Chang, Medha Krishnagiri, Aisha P. Patel et autres

Abstract Parkinson’s disease (PD) is a neurodegenerative disorder characterized by death of midbrain dopamine neurons. The pathogenesis of PD is poorly understood, though misfolded and/or aggregated forms of the protein α-synuclein have been implicated in several neurodegenerative disease processes, including neuroinflammation and …

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The Tug1 lncRNA locus is essential for male fertility

Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang et autres

BACKGROUND: Several long noncoding RNAs (lncRNAs) have been shown to function as components of molecular machines that play fundamental roles in biology. While the number of annotated lncRNAs in mammalian genomes has greatly expanded, studying lncRNA function has been a challenge due …

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Additional file 8 of The Tug1 lncRNA locus is essential for male fertility

Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang et autres

Additional file 8: Table S4. Allele-specific RNA-seq in testes, expression data.

Additional file 5 of The Tug1 lncRNA locus is essential for male fertility

Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang et autres

Additional file 5: Table S1. Tug1-/- and wild type sperm morphological defects.

Additional file 9 of The Tug1 lncRNA locus is essential for male fertility

Jordan P. Lewandowski, Gabrijela Dumbović, Audrey R. Watson, Taeyoung Hwang et autres

Additional file 9: Table S5. Allele-specific RNA-seq in testes, differentially expressed genes.