Accès ouvert
2025
conference-abstract
OpenAlex
Kevin H. Dang, Zahra Bahrami-Dizicheh, Harish Medlari, James Allison et autres
Background Gamma delta (γδ) T cells are a distinct subset of T cells with features of both innate and adaptive immunity. Based on their TCR δ chain usage, γδT cells can be divided into Vδ1 cells present in tissues, Vδ2 cells predominately …
us
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Accès ouvert
2025
article
OpenAlex
Ghenima Ahmil-Boiteau, Pranjali Dalvi, Kevin H. Dang, Harshad S. Ugamraj et autres
Introduction: CD38 is highly expressed on immune cells. It catabolizes NAD+, which is a critical cofactor for enzymes involved in metabolism and energy production. Methods and results: We developed TNB-738, a fully human antibody that potently inhibits human CD38 enzymatic activity on …
fr, us
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Accès ouvert
2023
article
OpenAlex
Alicia Climent-Catala, Iván Casas‐Rodrigo, Suhasini Iyer, Rodrigo Ledesma‐Amaro et autres
High Resolution Image Download MS PowerPoint Slide Protein-based fluorescent reporters have been widely used to characterize and localize biological processes in living cells. However, these reporters may have certain drawbacks for some applications, such as transcription-based studies or biological interactions with fast …
gb, ch
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Accès ouvert
2022
article
OpenAlex
Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein et autres
The use of T-cell engagers (TCEs) to treat solid tumors is challenging, and several have been limited by narrow therapeutic windows due to substantial on-target, off-tumor toxicities due to the expression of low levels of target antigens on healthy tissues. Here, we …
us
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Accès ouvert
2022
article
OpenAlex
Harshad S. Ugamraj, Kevin H. Dang, Laure‐Hélène Ouisse, Benjamin Buelow et autres
Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide. Other substrates of CD38 include nicotinamide adenine dinucleotide phosphate and nicotinamide mononucleotide, a critical …
fr, us, in
(code pays fourni par la source)
2022
conference-abstract
OpenAlex
Brian C. Avanzino, Kirthana Prabhakar, Pranjali Dalvi, Sharon Hartstein et autres
Abstract The use of T cell engagers (TCEs) to treat solid tumors in humans is challenging, and several have been limited by narrow therapeutic windows due to substantial toxicity. Dose-limiting toxicities of TCEs include cytokine release syndrome (CRS) and on-target, off-tumor toxicities …
us
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Accès ouvert
2021
article
OpenAlex
Kevin H. Dang, Giulia Castello, Starlynn Clarke, Yuping Li et autres
Background Therapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents an urgent medical need. T cell engagers (TCEs) have emerged as a …
us
(code pays fourni par la source)
2021
conference-abstract
OpenAlex
Ben D. Buelow, Pranjali Dalvi, Kevin H. Dang, Ashwin P. Patel et autres
TPS5092 Background: Prostate cancer (CaP) is the most common cancer in US men. Disseminated CaP invariably progresses to metastatic castrate-resistant prostate cancer (mCRPC). Current treatment options for mCRPC usually lead to therapeutic resistance, and novel therapies are urgently needed. PSMA is a …
us
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Accès ouvert
2021
article
OpenAlex
Katherine E. Harris, Kyle J. Lorentsen, Harbani K. Malik-Chaudhry, Kaitlyn Loughlin et autres
The use of recombinant interleukin-2 (IL-2) as a therapeutic protein has been limited by significant toxicities despite its demonstrated ability to induce durable tumor-regression in cancer patients. The adverse events and limited efficacy of IL-2 treatment are due to the preferential binding …
fr
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Accès ouvert
2021
article
OpenAlex
Harbani K. Malik-Chaudhry, Kirthana Prabhakar, Harshad S. Ugamraj, Andrew A. Boudreau et autres
The therapeutic potential of targeting CD19 in B cell malignancies has garnered attention in the past decade, resulting in the introduction of novel immunotherapy agents. Encouraging clinical data have been reported for T cell-based targeting agents, such as anti-CD19/CD3 bispecific T-cell engager …
us
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2020
conference-abstract
OpenAlex
Ben D. Buelow, Brian C. Avanzino, Aarti Balasubramani, Andrew A. Boudreau et autres
e18050 Background: Ovarian Cancer (OvCa) is the leading cause of gynecologic cancer mortality in women. Since the introduction of platinum-based chemotherapy there has been little change in the prognosis of OvCa patients, with < 30% overall survival in advanced disease, creating an …
us
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2020
conference-abstract
OpenAlex
Ben D. Buelow, Kevin H. Dang, Pranjali Dalvi, Yuping Li et autres
e17583 Background: Castration resistant prostate cancer (CRPC) is an incurable disease and represents a significant unmet need. Prostate specific membrane antigen (PSMA) is a protein highly expressed on the surface of prostate cancer cells; expression has been shown to increase with disease …
us
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