2026
conference-abstract
OpenAlex
Kevin H. Dang, Josiah Chang, Diane C. McLaughlin, Tracie Schroeder et autres
Background and Purpose: Tirofiban, a glycoprotein IIb/IIIa receptor inhibitor, has been studied as an adjunctive treatment in patients with acute ischemic stroke. In the recent RESCUE BT2 trial in China, intravenous (IV) tirofiban in patients without medium or large vessel occlusions was …
us
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Accès ouvert
2025
conference-abstract
OpenAlex
Kevin H. Dang, Zahra Bahrami-Dizicheh, Harish Medlari, James Allison et autres
Background Gamma delta (γδ) T cells are a distinct subset of T cells with features of both innate and adaptive immunity. Based on their TCR δ chain usage, γδT cells can be divided into Vδ1 cells present in tissues, Vδ2 cells predominately …
us
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Accès ouvert
2025
article
OpenAlex
Ghenima Ahmil-Boiteau, Pranjali Dalvi, Kevin H. Dang, Harshad S. Ugamraj et autres
Introduction: CD38 is highly expressed on immune cells. It catabolizes NAD+, which is a critical cofactor for enzymes involved in metabolism and energy production. Methods and results: We developed TNB-738, a fully human antibody that potently inhibits human CD38 enzymatic activity on …
fr, us
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2025
article
OpenAlex
Giovanni R. Malaty, Kevin H. Dang, Shafeeq S. Ladha, Michael Robers et autres
To present a case of KLHL11-Ma2/Ta Antibody Encephalitis in a man with adult-onset seizures, ataxia, subacute cognitive decline, and hemidystonia found to be antibody positive with a scrotal mixed germ-cell tumor.
us
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2025
article
OpenAlex
Kevin H. Dang, Justin L. Hoskin
To present a case of painful, unilateral trochlear nerve palsy in a patient with anti-GQ1b-positive Miller Fisher syndrome.
us
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2025
article
OpenAlex
Kyle N. Kaneko, Kevin H. Dang, Erik Ortega
To present a case of severe immune mediated necrotizing myositis in a patient with autoantibodies to HGMCR, MDA-5, CADM-140, NXP-2, and RNP without dermatologic involvement that was minimally responsive to intravenous immune globulin (IVIG) requiring cyclophosphamide.
us
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2025
article
OpenAlex
Alexa Rothenberg, Kevin H. Dang, Terry D. Fife
Lamotrigine (LTG) is a commonly used anticonvulsant and mood stabilizer. While generally well-tolerated, lamotrigine toxicity can occur. Presentation of lamotrigine toxicity can be diverse and include seizure, ocular abnormalities, ataxia, and encephalopathy, mimicking other neurological conditions, causing diagnostic challenges. Ocular findings are …
us
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2024
conference-abstract
OpenAlex
Suchismita Mohanty, Jeremy Chen, Alma Gomez, Angela C. Boroughs et autres
Abstract Common challenges of CAR-T cell therapies in solid tumors, such as clear cell renal cell carcinoma (ccRCC), include insufficient therapeutic potency and tumor specificity. AB-2100 is an autologous integrated circuit T cell product generated via CRISPR-mediated knock-in of a single transgene …
us
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2024
conference-abstract
OpenAlex
Suchismita Mohanty, Jeremy Chen, Alma Gomez, Angela C. Boroughs et autres
Abstract Common challenges of CAR-T cell therapies in solid tumors, such as clear cell renal cell carcinoma (ccRCC), include insufficient therapeutic potency and lack of tumor specificity. We have developed AB-2100, an autologous integrated circuit T (ICT) cell product, generated via CRISPR-mediated …
us
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Accès ouvert
2023
conference-abstract
OpenAlex
Irene Scarfò, Laura Lim, Kevin H. Dang, Marvin Chew et autres
Background Clinically effective CAR T cell therapy for solid tumors may require substantial T cell engineering to increase specificity and potency. We have developed AB-2100, an autologous, integrated circuit T (ICT) cell that encodes multiple synthetic ‘modules’ to overcome challenges in the …
us
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Accès ouvert
2022
article
OpenAlex
Harshad S. Ugamraj, Kevin H. Dang, Laure‐Hélène Ouisse, Benjamin Buelow et autres
Cluster of differentiation 38 (CD38) is an ecto-enzyme expressed primarily on immune cells that metabolizes nicotinamide adenine dinucleotide (NAD+) to adenosine diphosphate ribose or cyclic ADP-ribose and nicotinamide. Other substrates of CD38 include nicotinamide adenine dinucleotide phosphate and nicotinamide mononucleotide, a critical …
fr, us, in
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Accès ouvert
2021
article
OpenAlex
Kevin H. Dang, Giulia Castello, Starlynn Clarke, Yuping Li et autres
Background Therapeutic options currently available for metastatic castration-resistant prostate cancer (mCRPC) do not extend median overall survival >6 months. Therefore, the development of novel and effective therapies for mCRPC represents an urgent medical need. T cell engagers (TCEs) have emerged as a …
us
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