Bokkyoo Jun

Elovanoids, a Novel Class of Lipid Mediators, Are Neuroprotective in a Traumatic Brain Injury Model in Rats

Nicolas Guillermo Bazan, André Obenaus, Larissa Khoutorova, Pranab K. Mukherjee et autres

BACKGROUND: In the United States, traumatic brain injury (TBI) contributes significantly to mortality and morbidity. Elovanoids (ELVs), a novel class of homeostatic lipid mediators we recently discovered and characterized, have demonstrated neuroprotection in experimental stroke models but have never been tested after …

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Differential effect of an evolving amyloid and tau pathology on brain phospholipids and bioactive lipid mediators in rat models of Alzheimer-like pathology

Sonia Do Carmo, Marie-Audrey Ines Kautzmann, Surjyadipta Bhattacharjee, Bokkyoo Jun et autres

BACKGROUND: Brain inflammation contributes significantly to the pathophysiology of Alzheimer's disease, and it is manifested by glial cell activation, increased production of cytokines/chemokines, and a shift in lipid mediators from a pro-homeostatic to a pro-inflammatory profile. However, whether the production of bioactive …

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Transcriptomic signature, bioactivity and safety of a non-hepatotoxic analgesic generating AM404 in the midbrain PAG region

Hernan A. Bazán, Surjyadipta Bhattacharjee, Madigan M. Reid, Bokkyoo Jun et autres

Abstract Safe and effective pain management is a critical healthcare and societal need. The potential for acute liver injury from paracetamol (ApAP) overdose; nephrotoxicity and gastrointestinal damage from chronic non-steroidal anti-inflammatory drug (NSAID) use; and opioids’ addiction are unresolved challenges. We developed …

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Rod-specific downregulation of omega-3 very-long-chain polyunsaturated fatty acid pathway in age-related macular degeneration

William C. Gordon, Marie-Audrey Ines Kautzmann, Bokkyoo Jun, Megan L. Cothern et autres

Docosahexaenoic acid (DHA; 22:6) plays a key role in vision and is the precursor for very-long-chain polyunsaturated fatty acids (VLC-PUFAs). The release of 32- and 34-carbon VLC-PUFAs and DHA from sn-1 and sn-2 of phosphatidylcholine (PC) leads to the synthesis of cell-survival …

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Retina and RPE lipid profile changes linked with ABCA4 associated Stargardt's maculopathy

Mitra Farnoodian, Devika Bose, Francesca Barone, Luke Mathew Nelson et autres

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Transcriptomic signature, bioactivity and safety of a non-hepatoxic analgesic generating AM404 in the mid-brain PAG region

Hernan A. Bazán, Surjyadipta Bhattacharjee, Madigan M. Reid, Bokkyoo Jun et autres

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New Retinal Pigment Epithelial Cell Model to Unravel Neuroprotection Sensors of Neurodegeneration in Retinal Disease

Aram Asatryan, Jorgelina M. Calandria, Marie-Audrey Ines Kautzmann, Bokkyoo Jun et autres

. These cells remarkably recapitulate human eye native cells. Distinctive from other epithelia, RPE cells originate from the neural crest and follow a neural development but are terminally differentiated into "epithelial" type, thus sharing characteristics with their neuronal lineages counterparts. Additionally, they …

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Cerebrospinal Fluid Profile of Lipid Mediators in Alzheimer’s Disease

Khanh Do, Erik Hjorth, Ying Wang, Bokkyoo Jun et autres

Abstract Alzheimer’s disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) can be used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting from insufficient resolution is involved in …

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Intranasal delivery of pro-resolving lipid mediators rescues memory and gamma oscillation impairment in AppNL-G-F/NL-G-F mice

Ceren Emre, Luis Enrique Arroyo‐García, Khanh Do, Bokkyoo Jun et autres

Abstract Sustained microglial activation and increased pro-inflammatory signalling cause chronic inflammation and neuronal damage in Alzheimer’s disease (AD). Resolution of inflammation follows neutralization of pathogens and is a response to limit damage and promote healing, mediated by pro-resolving lipid mediators (LMs). Since …

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Abstract TP240: Novel Lipid Mediators C-36:6 And C-38:6 Administered Intranasally Are Neuroprotective In Experimental Ischemic Stroke

Madigan M. Reid, Larissa Khoutorova, Pranab K. Mukherjee, William Lewis et autres

Objective: Ischemic stroke induces multiple pathophysiological processes involving oxidative stress, loss of homeostasis, excitotoxicity, disruption of the blood-brain barrier and neurovascular unit, contributing to neuronal death. In the early phases following the onset of ischemic damage, neuroinflammation contributes to tissue damage and …

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Cerebrospinal Fluid Profile of Lipid Mediators In Alzheimer’s Disease

Khanh Do, Erik Hjorth, Ying Wang, Bokkyoo Jun et autres

Abstract Alzheimer’s disease (AD) develops into dementia over a period of several years, during which subjective cognitive impairment (SCI) and mild cognitive impairment (MCI) are used as intermediary diagnoses of increasing severity. Chronic neuroinflammation resulting from insufficient resolution is involved in the …

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Correction to: The expression of ELOVL4, repressed by MYCN, defines neuroblastoma patients with good outcome

Francesco Rugolo, Nicolas Guillermo Bazan, Jorgelina M. Calandria, Bokkyoo Jun et autres

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