Discovery of MK-2118, a Small-Molecule Agonist of STING
Timothy Henderson, Michael D. Altman, Alexei V. Buevich, Brandon Cash et autres
0 citationsACS Medicinal Chemistry Letters
Charles A. Lesburg
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85Publications signalées
4088Citations signalées
1Affiliations récentes
Institutions déclarées
Domaines associés
Hepatitis C virus researchBiochemical and Molecular ResearchHIV/AIDS drug development and treatmentEnzyme Structure and FunctionTryptophan and brain disorders
Publications récentes
The Discovery of Bridged Benzoazepine Amides as Selective Allosteric Modulators of RIPK1
Joanna L. Chen, Joey L. Methot, Matthew J. Mitcheltree, Andrew J. Musacchio et autres
4 citationsACS Medicinal Chemistry Letters
S1423 RIPK2 Scaffolding Inhibitors are a Novel Approach to Block RIPK2 Signaling, a Hallmark of Inflammatory Bowel Disease
Marta Wlodarska, Nneka E. Mbah, Florian Hoss, Rosana Meyer et autres
0 citationsThe American Journal of Gastroenterology
CCDC 2206667: Experimental Crystal Structure Determination
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon D. Kattar et autres
0 citationsThe Cambridge Structural Database
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1 H -Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
David A. Candito, Vladimir Simov, Anmol Gulati, Solomon D. Kattar et autres
27 citationsJournal of Medicinal Chemistry
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
Wonsuk Chang, Michael D. Altman, Charles A. Lesburg, Samanthi A. Perera et autres
146 citationsJournal of Medicinal Chemistry
A kinase-cGAS cascade to synthesize a therapeutic STING activator
John A. McIntosh, Zhijian Liu, Brian M. Andresen, Nastaran Salehi Marzijarani et autres
144 citationsNature
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing
Derun Li, David L. Sloman, Abdelghani Achab, Hua Zhou et autres
20 citationsJournal of Medicinal Chemistry
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors
Mitchell H. Keylor, Anmol Gulati, Solomon D. Kattar, Rebecca Johnson et autres
44 citationsJournal of Medicinal Chemistry
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors
Derun Li, Hongjun Zhang, Thomas W. Lyons, Min Lu et autres
22 citationsACS Medicinal Chemistry Letters
Utilization of Metabolite Identification and Structural Data to Guide Design of Low-Dose IDO1 Inhibitors
Brett A. Hopkins, Hongjun Zhang, Indu Bharathan, Derun Li et autres
9 citationsACS Medicinal Chemistry Letters
Discovery of IDO1 inhibitors containing a decahydroquinoline, decahydro-1,6-naphthyridine, or octahydro-1H-pyrrolo[3,2-c]pyridine scaffold
Wensheng Yu, Yongqi Deng, David L. Sloman, Derun Li et autres
10 citationsBioorganic & Medicinal Chemistry Letters
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