Discovery of MK-2118, a Small-Molecule Agonist of STING
Timothy Henderson, Michael D. Altman, Alexei V. Buevich, Brandon Cash et autres
Agonists of Stimulator of Interferon Genes (STING) have the potential to activate the innate and adaptive immune system for cancer treatment. Early efforts in identifying suitable therapeutics were focused on cyclic dinucleotide (CDN) analogs of 2',3'-cGAMP, the endogenous ligand to STING. CDNs …
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ACS Medicinal Chemistry Letters