Jürgen Knobloch

Cytokine production of mononuclear leukocytes in response to respiratory syncytial virus is increased in COPD but suppressed in non-COPD tobacco smokers

Sarah Yanik, Kaschin Jamal Jameel, Simon Rohde, Paul Bürger et autres

BACKGROUND: Respiratory syncytial virus (RSV) induces exacerbations of chronic obstructive pulmonary disease (COPD) that are critical for disease progression and burden. COPD subjects have an increased susceptibility to viral respiratory infections. We aimed to identify underlying systemic immune pathologies that could be …

de, at, gb (code pays fourni par la source)

Bifurcation Theory

Ale Jan Homburg, Jürgen Knobloch

nl, de (code pays fourni par la source)

Functional characterization of OR51B5 and OR1G1 in human lung epithelial cells as potential drug targets for non-type 2 lung diseases

Noha Awad, Daniel Weidinger, Lea Greune, Juliane Kronsbein et autres

BACKGROUND: Hypersensitivity to odorants like perfumes can induce or promote asthma with non-type 2 inflammation for which therapeutic options are limited. Cell death of primary bronchial epithelial cells (PBECs) and the release of the pro-inflammatory cytokines interleukin-6 (IL-6) and IL-8 are key …

Égypte, de (code pays fourni par la source)

Olfactory receptors impact pathophysiological processes of lung diseases in bronchial epithelial cells

Daniel Weidinger, Julian Jacobsen, Desiree Alisch, Hendrik Uebner et autres

BACKGROUND: Therapeutic options for steroid-resistant non-type 2 inflammation in obstructive lung diseases are limited. Bronchial epithelial cells are key in the pathogenesis by releasing the central proinflammatory cytokine interleukine-8 (IL-8). Olfactory receptors (ORs) are expressed in various cell types. This study examined …

de, sk (code pays fourni par la source)

Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of cells from nasal polyps

Jonghui Kim, Karla Hegener, Claudia Hagedorn, Daniel Weidinger et autres

BACKGROUND: Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore essential to establish a robust method for the isolation and culture of epithelial cells from nasal polyps to enable further research. In this …

de (code pays fourni par la source)

Simple, low-cost and well-performing method for isolation of epithelial cells from nasal polyps with outgrowth technique

Jonghui Kim, Karla Hegener, Claudia Hagedorn, Jamal Kaschin Jameel et autres

Background Epithelial cells (EC) are an important component of the pathomechanism of type 2 inflammation in chronic rhinosinusitis with nasal polyps. Therefore, it is important to establish a robust method for isolation and culture of EC from nasal polyps to enable further …

de (code pays fourni par la source)

Establishment of organ culture as an investigation tool for chronic rhinosinusitis with nasal polyps.

Tina Veleva, Jonghui Kim, Karla Hegener, Jamal Kaschin Jameel et autres

Background Chronic rhinosinusitis with nasal polyps is commonly caused by a complex Th-2 cell-based inflammatory response in Western countries. However, the exact pathomechanism is still largely unknown. In order to enable further sufficient investigations and new insights, it is necessary to develop …

de (code pays fourni par la source)

Etablierung einer Organkultur als Untersuchungsinstrument für chronische Rhinosinusitis mit Nasenpolypen

Tina Veleva, Jonghui Kim, Karla Hegener, Jamal Kaschin Jameel et autres

Hintergrund Die chronische Rhinosinusitis mit Nasenpolypen wird in den westlichen Ländern häufig durch eine komplexe, auf Th-2-Zellen basierende Entzündungsreaktion verursacht. Der genaue Pathomechanismus ist jedoch noch weitgehend unbekannt. Um weitergehende suffiziente Untersuchungen und neue Erkenntnisse ermöglichen zu können, ist es erforderlich, ein …

de (code pays fourni par la source)

Einfache, kostengünstige und gut funktionierende Methode zur Isolierung von Epithelzellen aus Nasenpolypen mit Outgrowth-Technik

Jonghui Kim, Karla Hegener, Claudia Hagedorn, Jamal Kaschin Jameel et autres

Hintergrund Epithelzellen (EC) sind ein wichtiger Bestandteil des Pathomechanismus der Typ-2-Inflammation bei chronischer Rhinosinusitis mit Nasenpolypen. Es ist daher wichtig, eine robuste Methode zur Isolierung und Kultur von EC aus Nasenpolypen zu etablieren, um weitere Untersuchungen zu ermöglichen. In dieser Studie wurde …

de (code pays fourni par la source)

Long-Term Cryopreservation of Nasal Polyp Tissue in a Biobank for the Isolation and Culture of Primary Epithelial Cells

Jonghui Kim, Karla Hegener, Claudia Hagedorn, Kaschin Jamal Jameel et autres

Epithelial cells may play an important role in the pathologic process of chronic rhinosinusitis with nasal polyps. Therefore, providing epithelial cells from a biobank could greatly contribute to further research. In the present work, the isolation of epithelial cells from long-term cryopreserved …

de (code pays fourni par la source)

Olfactory receptors affect inflammatory processes of lung epithelial cells

Daniel Weidinger, J Jacobsen, Kaschin Jamal Jameel, Desiree Alisch et autres

Background Lung epithelial cells are centrally involved in the development of non-type 2 inflammation, e.g. in COPD and cystic fibrosis, for which therapeutic options are needed. Olfactory receptors (ORs) belong to the group of pharmacologically used G-protein coupled receptors and are expressed …

de (code pays fourni par la source)

Simple, low-cost, and well-performing method, the outgrowth technique, for the isolation of epithelial cells from nasal polyps

Jonghui Kim, Karla Hegener, Claudia Hagedorn, Kaschin Jamal Jameel et autres

ABSTRACT Objectives Epithelial cells are an important part of the pathomechanism in chronic rhinosinusitis with nasal polyps. It is therefore essential to establish a robust method for the isolation and culture of epithelial cells from nasal polyps to enable further research. In …

de (code pays fourni par la source)