Stephanie Hirner

Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1

Siegfried Labeit, Stephanie Hirner, Julius Bogomolovas, André Cruz et autres

The muscle-specific ubiquitin ligase MuRF1 regulates muscle catabolism during chronic wasting states, although its roles in general metabolism are less-studied. Here, we metabolically profiled MuRF1-deficient knockout mice. We also included knockout mice for MuRF2 as its closely related gene homolog. MuRF1 and …

de, br, kz, gb (code pays fourni par la source)

MuRF1 is a muscle fiber-type II associated factor and together with MuRF2 regulates type-II fiber trophicity and maintenance

Anselmo Sigari Moriscot, Igor L. Baptista, Julius Bogomolovas, Christian Witt et autres

br, de, us (code pays fourni par la source)

Abstract 3789: Induction of Murf-1 is Required for Tnf-alpha Induced Loss of Skeletal Muscle Function

Volker Adams, Norman Magner, Axel Linke, Alexander Gasch et autres

Background: Inflammatory cytokines like tumor necrosis factor alpha (TNF-α) are known to impair skeletal muscle (SM) function. Furthermore, TNF-α induces the expression of atrogin-like muscle specific ubiquitin E3-ligases, presumed to mediate muscle atrophy. The relative contributions of respective ubiquitin ligases, like MuRF1 …

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Induction of MuRF1 Is Essential for TNF-α-Induced Loss of Muscle Function in Mice

Volker Adams, Norman Mangner, Alexander Gasch, Christian Krohne et autres

de (code pays fourni par la source)

Roles of Skeletal Muscle-Specific Calpain, p94/calpain 3, on Multiple Molecular Interactions Using Connectin/titin N2A Region as a Modulating Scaffold

Yasuko Ono, Chikara Hayashi, N. Doi, Fujiko Kitamura et autres

1 Calpain Project, Rinshoken, Tokyo, Japan 2 Department of Applied Biological Science, Faculty of Science and Technology, Tokyo University of Science, Chiba, Japan 3 CREST, JST, Saitama, Japan 4 Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan 5 Institute …

MuRF1-dependent Regulation of Systemic Carbohydrate Metabolism as Revealed from Transgenic Mouse Studies

Stephanie Hirner, Christian Krohne, Alexander Schuster, Sigrid Hoffmann et autres

de (code pays fourni par la source)

Multiple Molecular Interactions Implicate the Connectin/Titin N2A Region as a Modulating Scaffold for p94/Calpain 3 Activity in Skeletal Muscle

Chikako Hayashi, Yasuko Ono, Naoko Doi, Fujiko Kitamura et autres

p94/calpain 3 is a skeletal muscle-specific Ca(2+)-regulated cysteine protease (calpain), and genetic loss of p94 protease activity causes muscular dystrophy (calpainopathy). In addition, a small in-frame deletion in the N2A region of connectin/titin that impairs p94-connectin interaction causes a severe muscular dystrophy …

jp, de (code pays fourni par la source)

Critical Illness Polyneuropathy und Critical Illness Myopathy. Pathogenese und Diagnostik

Markus Alb, Stephanie Hirner, Thomas Luecke

Die 'critical illness polyneuropathy' (CIP) und die Žcritical illness myopathyŽ sind seit der Erstbeschreibung von Bolton et al. zunehmend beachtete Komplikationen bei Intensivpatienten. CIP und CIM, alleine oder in Kombination, treten gewöhnlich bei Patienten auf, die länger als eine Woche auf einer …

de (code pays fourni par la source)

Deficiency in the LIM-only protein Fhl2 impairs skin wound healing

Viktor Wixler, Stephanie Hirner, Judith M. Müller, Lucia Gullotti et autres

After skin wounding, the repair process is initiated by the release of growth factors, cytokines, and bioactive lipids from injured vessels and coagulated platelets. These signal molecules induce synthesis and deposition of a provisional extracellular matrix, as well as fibroblast invasion into …

de, at, ru (code pays fourni par la source)