Masayoshi Kusumi

Thrombolysis for Acute Wake-Up and Unclear-Onset Strokes with Alteplase at 0.6 mg/kg in Clinical Practice: THAWS2 Study

Sohei Yoshimura, Masatoshi Koga, Takashi Okada, Manabu Inoue et autres

INTRODUCTION: The aim of this study was to determine the safety and efficacy of intravenous (IV) alteplase at 0.6 mg/kg for patients with acute wake-up or unclear-onset strokes in clinical practice. METHODS: This multicenter observational study enrolled acute ischemic stroke patients with …

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Supplementary Material for: Thrombolysis for acute wake-up and unclear onset strokes with alteplase at 0.6 mg/kg in clinical practice: THAWS2 Study

Sohei Yoshimura, Masatoshi Koga, Takashi Okada, Masatoshi Inoue et autres

Introduction: The aim of this study was to determine the safety and efficacy of intravenous (IV) alteplase at 0.6 mg/kg for patients with acute wake-up or unclear onset strokes in clinical practice. Methods: This multicenter observational study enrolled acute ischemic stroke patients …

Supplementary Material for: Thrombolysis for acute wake-up and unclear onset strokes with alteplase at 0.6 mg/kg in clinical practice: THAWS2 Study

Sohei Yoshimura, Masatoshi Koga, Takahiro Okada, Masatoshi Inoue et autres

Introduction: The aim of this study was to determine the safety and efficacy of intravenous (IV) alteplase at 0.6 mg/kg for patients with acute wake-up or unclear onset strokes in clinical practice. Methods: This multicenter observational study enrolled acute ischemic stroke patients …

Tumefactive eosinophil‐rich non‐granulomatous small vessel vasculitis in the cerebrum in a patient with idiopathic hypereosinophilic syndrome

Yoshifumi Noro, Hajime Miyata, Takuya Furuta, Yasuo Sugita et autres

The definite diagnosis of central nervous system vasculitis requires pathological verification by biopsy or surgical resection of the lesion, which may not always be feasible. A 74-year-old woman with a history of allergic rhinitis, but not asthma, presented with slowly progressive left …

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Medullary and upper cervical cord infarction caused by occlusion of the unilateral vertebral artery

Masahiro Kanatani, Shota Matsumoto, Yuko Yoshimoto, Masayoshi Kusumi

症例は80歳男性．入浴後に意識障害，眼振，構音障害，右上下肢麻痺を発症し救急搬送となった．頭部MRIでは左頭頂葉皮質下の微小急性期梗塞を認め，magnetic resonance angiography（MRA）では左内頸動脈狭窄を認めたため，アテローム血栓性脳梗塞と診断し入院となった．入院翌日，吸痰中に突然意識レベルがJCSIII-300に低下し呼吸停止となった．気管挿管，人工呼吸器管理を開始し意識レベルの改善を認めたが，四肢麻痺が持続した．入院4日目に施行した頭頸部MRIでは右延髄～上位頸髄にかけての長軸進展病変を認め，computed tomography angiography（CTA）で右椎骨動脈閉塞の所見があり，梗塞と診断した．片側椎骨動脈閉塞で上位頸髄梗塞を来す可能性があり，注意が必要である．

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Abstract MP6: Thrombolysis for Acute Wake-Up And Unclear Onset Strokes With Alteplase at 0.6mg /kg in Clinical Practice: THAWS2 Study

Sohei Yoshimura, Masatoshi Koga, Takashi Okada, Manabu Inoue et autres

Background and Purpose: IV alteplase at 0.6 mg/kg for acute wake-up and unclear onset strokes was recommended in Japanese stroke guidelines in March 2019. We determined the safety and effectiveness of this newly recommended thrombolysis in clinical practice. Methods: This is a …

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Intravenous alteplase for stroke with unknown time of onset guided by advanced imaging: systematic review and meta-analysis of individual patient data

Götz Thomalla, Florent Boutitie, Henry Ma, Masatoshi Koga et autres

BACKGROUND: Patients who have had a stroke with unknown time of onset have been previously excluded from thrombolysis. We aimed to establish whether intravenous alteplase is safe and effective in such patients when salvageable tissue has been identified with imaging biomarkers. METHODS: …

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Association between Serum Uric Acid Level and Activity of Daily Living in Japanese Patients with Ischemic Stroke

Shinya Kawase, Hisanori Kowa, Yutaka Suto, Hiroki Fukuda et autres

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Association between body mass index and outcome in J apanese ischemic stroke patients

Shinya Kawase, Hisanori Kowa, Yutaka Suto, Hiroki Fukuda et autres

AIM: An association between body mass index (BMI) and stroke outcome have been reported, but the results are controversial. The aim of the present study was to evaluate whether BMI is associated with ischemic stroke outcome. METHODS: ). BMI and short-term and …

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Plasma Brain Natriuretic Peptide is a Marker of Prognostic Functional Outcome in Non–Cardioembolic Infarction

Shinya Kawase, Hisanori Kowa, Yutaka Suto, Hiroki Fukuda et autres

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Validity of the J apanese version of the REM S leep B ehavior D isorder ( RBD ) Screening Questionnaire for detecting probable RBD in the general population

Takashi Nomura, Yuichi Inoue, Tatsuo Kagimura, Masayoshi Kusumi et autres

AIMS: In order to evaluate the validity of the REM Sleep Behavior Disorder (RBD) Screening Questionnaire (RBDSQ) as a screening tool for RBD in a general population setting, we conducted a validation study using residents of a rural community. METHODS: We sent …

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Epidemiological Survey of Frontotemporal Lobar Degeneration in Tottori Prefecture, Japan

Kenji Wada‐Isoe, Satoru Ito, Tadashi Adachi, Mika Yamawaki et autres

BACKGROUND: The prevalence of frontotemporal lobar degeneration (FTLD) in Japan is unknown. An epidemiological survey study of FTLD was undertaken in Tottori Prefecture, a district in the western region of Japan. METHODS: Hospitals in Tottori Prefecture were surveyed by a two-step questionnaire …

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