Masatoshi Inoue

Author Correction: Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida et autres

In the version of the article initially published, in the “Myeloid cells signal FBs via the EGF and platelet-derived growth factor (PDGF) pathways” section, the sentence “GO enrichment analysis revealed enrichment of ‘response to fibroblast growth factor’ and ‘myeloid leukocyte differentiation’ (biological …

jp (code pays fourni par la source)

Left atrial single-cell transcriptomics reveals amphiregulin as a surrogate marker for atrial fibrillation

Yuya Suzuki, Takuo Emoto, Shunsuke Sato, Takeshi Yoshida et autres

Atrial fibrillation (AF) is strongly associated with strokes, heart failure, and increased mortality. This study aims to identify the monocyte–macrophage heterogeneity and interactions of these cells with non-immune cells, and to identify functional biomarkers in patients with AF. Therefore, we assess the …

jp (code pays fourni par la source)

Single-Cell RNA Sequencing Reveals an Immune Landscape of CD4+ T Cells in Coronary Culprit Plaques With Acute Coronary Syndrome in Humans—Brief Report

Shintaro Takeda, Takuo Emoto, Tomoya Yamashita, Hiroyuki Yamamoto et autres

BACKGROUND: Acute coronary syndrome (ACS) involves plaque-related thrombosis, causing primary ischemic cardiomyopathy or lethal arrhythmia. We previously demonstrated a unique immune landscape of myeloid cells in the culprit plaques causing ACS by using single-cell RNA sequencing. Here, we aimed to characterize T …

jp (code pays fourni par la source)

All-optical observation and control of communication between neuronal cell-types during behavior via structure-guided design of channelrhodopsins

Masatoshi Inoue, Karl Deisseroth

Understanding the nature and role of communication between distinct cellular populations in the brain will require simultaneous measurement and control of activity within those populations during behavior. Current optogenetic tools, present limitations such as spectral incompatibility with sensors and modest efficacy. To …

us (code pays fourni par la source)

Structural basis for ion selectivity in potassium-selective channelrhodopsins

Seiya Tajima, Yoon Seok Kim, Masahiro Fukuda, YoungJu Jo et autres

KCR channelrhodopsins (K + -selective light-gated ion channels) have received attention as potential inhibitory optogenetic tools but more broadly pose a fundamental mystery regarding how their K + selectivity is achieved. Here, we present 2.5–2.7 Å cryo-electron microscopy structures of Hc KCR1 …

jp, us, gb (code pays fourni par la source)

Cardiogenic control of affective behavioural state

Brian Hsueh, Ritchie Chen, YoungJu Jo, Daniel D. Tang et autres

Abstract Emotional states influence bodily physiology, as exemplified in the top-down process by which anxiety causes faster beating of the heart 1–3 . However, whether an increased heart rate might itself induce anxiety or fear responses is unclear 3–8 . Physiological theories …

us (code pays fourni par la source)

Supplementary Material for: Thrombolysis for acute wake-up and unclear onset strokes with alteplase at 0.6 mg/kg in clinical practice: THAWS2 Study

Sohei Yoshimura, Masatoshi Koga, Takashi Okada, Masatoshi Inoue et autres

Introduction: The aim of this study was to determine the safety and efficacy of intravenous (IV) alteplase at 0.6 mg/kg for patients with acute wake-up or unclear onset strokes in clinical practice. Methods: This multicenter observational study enrolled acute ischemic stroke patients …

Supplementary Material for: Thrombolysis for acute wake-up and unclear onset strokes with alteplase at 0.6 mg/kg in clinical practice: THAWS2 Study

Sohei Yoshimura, Masatoshi Koga, Takahiro Okada, Masatoshi Inoue et autres

Introduction: The aim of this study was to determine the safety and efficacy of intravenous (IV) alteplase at 0.6 mg/kg for patients with acute wake-up or unclear onset strokes in clinical practice. Methods: This multicenter observational study enrolled acute ischemic stroke patients …

Structural basis for ion selectivity in potassium-selective channelrhodopsins

Seiya Tajima, Yoon Seok Kim, Masahiro Fukuda, Eamon F.X. Byrne et autres

SUMMARY The KCR channelrhodopsins are recently-discovered light-gated ion channels with high K + selectivity, a property that has attracted broad attention among biologists– due to intense interest in creating novel inhibitory tools for optogenetics leveraging this K + selectivity, and due to …

jp, us, gb (code pays fourni par la source)

CCDC 2183753: Experimental Crystal Structure Determination

Mitsunobu Doi, Toshimasa Ishida, Shigetoshi Sugio, Takashi Imagawa et autres

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, …

A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo

Masayuki Sakamoto, Masatoshi Inoue, Atsuya Takeuchi, Shigetaka Kobari et autres

Genetically encoded calcium indicators (GECIs) are widely used to measure calcium transients in neuronal somata and processes, and their use enables the determination of action potential temporal series in a large population of neurons. Here, we generate a transgenic mouse line expressing …

jp, us (code pays fourni par la source)

A Flp-dependent G-CaMP9a transgenic mouse for neuronal imaging in vivo

Masayuki Sakamoto, Masatoshi Inoue, Atsuya Takeuchi, Shigetaka Kobari et autres

Genetically encoded calcium indicators (GECIs) are widely used to measure calcium transients in neuronal somata and processes, and their use enables the determination of action potential temporal series in a large population of neurons. Here, we generate a transgenic mouse line expressing …

jp, us (code pays fourni par la source)