Accès ouvert
2024
article
OpenAlex
Aharon Steffè, Francesca Milano, Santiago Giménez Reyes, Francesca Buco et autres
polymers form supramolecular assemblies. Physico chemical characteristics and pH responsiveness of the assemblies are correlated with the number of dextran chains per PAH molecule. Nanocapsules (NCs) are formed when PAH:DEX ratio is 1. Capsule formation is explained by the branched nature of …
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2024
article
OpenAlex
Daniel Alpízar-Pedraza, Yessica Roque-Diaz, Hilda Garay, Frank Rosenau et autres
CIDEM-501 is a hybrid antimicrobial peptide rationally designed based on the structure of panusin and panulirin template peptides. The new peptide exhibits significant antibacterial activity against multidrug-resistant pathogens (MIC = 2-4 μM) while conserving no toxicity in human cell lines. We conducted …
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Accès ouvert
2023
article
OpenAlex
Alessandro Paciaroni, Valeria Libera, Francesca Ripanti, A. Orecchini et autres
The main protease (Mpro or 3CLpro) is an enzyme that is evolutionarily conserved among different genera of coronaviruses. As it is essential for processing and maturing viral polyproteins, Mpro has been identified as a promising target for the development of broad-spectrum drugs …
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Accès ouvert
2021
article
OpenAlex
Yessica Roque-Diaz, Martina Sanadar, Dong Han, Montserrat López‐Mesas et autres
The uncontrolled release of pharmaceutical drugs into the environment raised serious concerns in the last decades as they can potentially exert adverse effects on living organisms even at the low concentrations at which they are typically found. Among them, platinum based cytostatic …
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