A. Orecchini

Phosphatidylserine lipids reduce the adsorption of chondroitin sulphate at the membrane surface

Brigida Romano, Roberto Menichetti, Nicoló Paracini, Philipp Gutfreund et autres

Hypothesis Chondroitin sulphate (CS) is a linear polysaccharide typically found on the surface of cells and contributing to the structure of the extracellular matrix. Because of its proximity to the plasma membrane, the outermost cellular barrier, CS can interact with the phospholipids …

it, se, fr (code pays fourni par la source)

Phosphatidylserine lipids affect the location of chondroitin sulfate at the membrane surface

Brigida Romano, Roberto Menichetti, Nicoló Paracini, Philipp Gutfreund et autres

it, dk, fr (code pays fourni par la source)

Probing Residual Water in G-Quadruplex Structures through Molecular Vibrations

Valeria Libera, Sara Catalini, Francesca Ripanti, Luca Bertini et autres

G-quadruplexes (GQs), noncanonical DNA structures involved in gene regulation and genome stability, exhibit a high structural polymorphism that is strongly modulated by their solvation environment. Here we employ a dual-spectroscopy approach, combining ultraviolet resonance Raman (UVRR) scattering with circular dichroism (CD), to …

it, ch (code pays fourni par la source)

Hindered intermolecular stacking of anti-parallel telomeric G-quadruplexes

Luca Bertini, Valeria Libera, Sara Catalini, Giorgio Schirò et autres

Telomeric G-quadruplexes (G4s) are non-canonical DNA structures composed of TTAGGG repeats. They are extensively studied both as biomolecules key for genome stability and as promising building blocks and functional elements in synthetic biology and nanotechnology. This is why it is extremely important …

it, fr (code pays fourni par la source)

Water slowing down drives the occurrence of the low temperature dynamical transition in microgels

Letizia Tavagnacco, Marco Zanatta, Elena Buratti, Monica Bertoldo et autres

-isopropyl acrylamide) (PNIPAM) microgels, bearing many similarities to proteins. While the generality of this phenomenon is well-established, the role of water in the transition remains a subject of debate. In this study, we use atomistic molecular dynamics (MD) simulations and elastic incoherent …

it, fr (code pays fourni par la source)

Disclosing the nature of the collective THz dynamics in hydrogen bonded liquids

Marco Zanatta, A. Orecchini, F. Sacchetti, C. Petrillo

The behavior of liquids has always been a subject of strong interest and still presents many challenging issues. A paradigmatic example is the understanding of their atomic-scale collective dynamics. Experimentally accessible to inelastic neutron and X-ray scattering, this regime has recently disclosed …

it (code pays fourni par la source)

Stacking Interactions and Flexibility of Human Telomeric Multimers

B. Rosi, Valeria Libera, Luca Bertini, A. Orecchini et autres

G-quadruplexes (G4s) are helical four-stranded structures forming from guanine-rich nucleic acid sequences, which are thought to play a role in cancer development and malignant transformation. Most current studies focus on G4 monomers, yet under suitable and biologically relevant conditions, G4s undergo multimerization. …

it, fr, de (code pays fourni par la source)

Stabilization of the Dimeric State of SARS-CoV-2 Main Protease by GC376 and Nirmatrelvir

Alessandro Paciaroni, Valeria Libera, Francesca Ripanti, A. Orecchini et autres

The main protease (Mpro or 3CLpro) is an enzyme that is evolutionarily conserved among different genera of coronaviruses. As it is essential for processing and maturing viral polyproteins, Mpro has been identified as a promising target for the development of broad-spectrum drugs …

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Polymorphism and Ligand Binding Modulate Fast Dynamics of Human Telomeric G-Quadruplexes

Luca Bertini, Valeria Libera, Francesca Ripanti, Francesca Natali et autres

Telomeric G-quadruplexes (G4s) are promising targets in the design and development of anticancer drugs. Their actual topology depends on several factors, resulting in structural polymorphism. In this study, we investigate how the fast dynamics of the telomeric sequence AG3(TTAG3)3 (Tel22) depends on …

it (code pays fourni par la source)

Impact of the Environment on the PNIPAM Dynamical Transition Probed by Elastic Neutron Scattering

B. Rosi, Arianna D’Angelo, Elena Buratti, Marco Zanatta et autres

By means of elastic incoherent neutron scattering, \nwe investigated how the addition of stabilizing cosolvents (glycerol \nand glucose) affects the dynamics of hydrated PNIPAM chains at \nthe pico- and nanosecond time scale, where a low-temperature \ndynamical transition is observed. From the elastic …

it, fr, de, se (code pays fourni par la source)

The role of polymer structure on water confinement in poly(N-isopropylacrylamide) dispersions

Elena Buratti, Letizia Tavagnacco, Marco Zanatta, Ester Chiessi et autres

it (code pays fourni par la source)

Connecting Structure, Conformation and Energetics of Human Telomere G-quadruplex Multimers

B. Rosi, Valeria Libera, A. Orecchini, S. Corezzi et autres

G-quadruplexes (G4s) are helical four-stranded structures forming from guanine-rich nucleic acid sequences, which are thought to play a role in cancer development and malignant transformation. Most current studies focus on G4 monomers, yet under suitable and biologically relevant conditions G4s undergo multimerization. …