Samuel E. Zimmerman

Microbiota-mediated induction of beige adipocytes in response to dietary cues

Takeshi Tanoue, Manabu Nagayama, Ayumi J. A. Roochana, Samuel E. Zimmerman et autres

Interactions between diet and the gut microbiota are fundamental to metabolic health, shaping energy balance and disease susceptibility1–5. However, the underlying mechanisms by which dietary and microbial factors converge to regulate host physiology remain unclear. Here we show that protein availability profoundly …

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Specification curve analysis of the TEDDY study reveals large variation in microbiome-based T1D predictive performance

Samuel E. Zimmerman, Braden T. Tierney, Vy Kim Nguyen, Aleksandar David Kostic et autres

The microbiome may play a role in predicting future Type 1 Diabetes (T1D) risk. Associations between the microbiome and T1D onset are well documented but observational microbiome studies are difficult to interpret and reproduce due to differences in study designs. To evaluate …

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Body dissatisfaction widens the racial disparities of Benzophenone-3, a chemical biomarker of personal care and consumer product usage

Vy Kim Nguyen, Samuel E. Zimmerman, Justin A. Colacino, Olivier Jolliet et autres

Abstract Background Body dissatisfaction can drive individuals to use personal care products, exposing themselves to Benzophenone-3 (BP3). Yet, no study has examined the link between body dissatisfaction and elevated chemical exposures. Objectives Our study examines how body dissatisfaction impacts the racial differences …

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Body dissatisfaction widens the racial disparities of Benzophenone-3, a chemical biomarker of personal care and consumer product usage

Vy Kim Nguyen, Samuel E. Zimmerman, Justin A. Colacino, Chirag J. Patel et autres

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Superior Induced Pluripotent Stem Cell Generation through Phactr3-Driven Mechanomodulation of Both Early and Late Phases of Cell Reprogramming

Mohammad Mahfuz Chowdhury, Samuel E. Zimmerman, Hannah C. Leeson, Christian Maximilian Nefzger et autres

Human cell reprogramming traditionally involves time-intensive, multistage, costly tissue culture polystyrene-based cell culture practices that ultimately produce low numbers of reprogrammed cells of variable quality. Previous studies have shown that very soft 2- and 3-dimensional hydrogel substrates/matrices (of stiffnesses ≤ 1 kPa) …

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Body Dissatisfaction Widens the Racial Disparities of Benzophenone-3, a Chemical Biomarker of Personal Care and Consumer Product Usage

Vy Kim Nguyen, Samuel E. Zimmerman, Justin A. Colacino, Olivier Jolliet et autres

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Near Real-Time Identification of Recent Human Immunodeficiency Virus Transmissions, Transmitted Drug Resistance Mutations, and Transmission Networks by Multiplexed Primer ID–Next-Generation Sequencing in North Carolina

Samuel E. Zimmerman, Andrew E. Cressman, M. S. Cohen, Mary E. Clark et autres

Background: The identification of recent human immunodeficiency virus (HIV) 1 infections among people with new HIV diagnoses is important to both tailoring and assessing the impact of HIV-1 prevention strategies. Methods: We developed a multiplexed Primer ID-next-generation sequencing approach to identify recent …

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Combatting SARS-CoV-2 With Digital Contact Tracing and Notification: Navigating Six Points of Failure

Joanna Masel, James Ian Mackie Petrie, Jason Bay, Wolfgang E. Ebbers et autres

Digital contact tracing and notification were initially hailed as promising strategies to combat SARS-CoV-2; however, in most jurisdictions, they did not live up to their promise. To avert a given transmission event, both parties must have adopted the technology, it must detect …

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Superior induced pluripotent stem cell generation through phactr-3-driven mechano-modulation of both early and late phases of cell reprogramming

Mohammad A. Chowdhury, Samuel E. Zimmerman, Hannah C. Leeson, Christian Maximilian Nefzger et autres

Abstract Background:Human cell reprogramming traditionally involves time-intensive, multi-stage, costly tissue culture polystyrene (TCPS)-based cell culture practices that ultimately produce low numbers of reprogrammed cells of variable quality. Previous studies have shown that very soft two-and three-dimensional hydrogel substrates/matrices (of stiffnesses </= 1 …

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Combatting SARS-CoV-2 With Digital Contact Tracing and Notification: Navigating Six Points of Failure (Preprint)

Joanna Masel, James Ian Mackie Petrie, Jason Bay, Wolfgang E. Ebbers et autres

UNSTRUCTURED Digital contact tracing and notification were initially hailed as promising strategies to combat SARS-CoV-2; however, in most jurisdictions, they did not live up to their promise. To avert a given transmission event, both parties must have adopted the technology, it must …

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Quantifying Shared and Unique Gene Content across 17 Microbial Ecosystems

Samuel E. Zimmerman, Braden T. Tierney, Chirag J. Patel, Aleksandar David Kostic

The amount of shared genetic elements has not been quantified between the human microbiome and other host- and non-host-associated microbiomes. Here, we made a gene catalog of 17 different microbial ecosystems and compared them. We show that most species shared between environment …

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Substrate stiffness facilitates improved induced pluripotent stem cell production through modulation of both early and late phases of cell reprogramming

Mohammad A. Chowdhury, Samuel E. Zimmerman, Hannah C. Leeson, Christian Maximilian Nefzger et autres

Abstract Cell reprogramming involves time-intensive, costly processes that ultimately produce low numbers of reprogrammed cells of variable quality. By screening a range of polyacrylamide hydrogels (pAAm gels) of varying stiffness (1 kPA – 1.3 MPa) we found that a gel of medium …

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